recent publications
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academic article
- Nishiguchi, G. A., Rico, A., Tanner, H., Aversa, R. J., Taft, B. R., Subramanian, S., Setti, L., Burger, M. T., Wan, L. F., Tamez, V., Smith, A., Lou, Y., et al. Design and discovery of N-(2-Methyl-5 '-morpholino-6 '-((tetrahydro-2H-pyran-4-yl)oxy)- 3,3 '-bipyridin -5-yl)-3-(trifluoromethyl)benzamide (RAF709): a potent, selective, and efficacious RAF inhibitor targeting RAS mutant cancers Journal of Medicinal Chemistry 2017 60:4869-4881 DOI:10.1021/acs.jmedchem.6b01862 PMID:28557458
- Barsanti, P. A., Aversa, R. J., Jin, X., Pan, Y., Lu, Y., Elling, R., Jain, R., Knapp, M., Lan, J., Lin, X., Rudewicz, P., Sim, J., et al. Structure-based drug design of novel potent and selective tetrahydropyrazolo 1,5-a pyrazines as ATR inhibitors ACS Medicinal Chemistry Letters 2015 6:37-41 DOI:10.1021/ml500353p PMID:25589927 PMCID:PMC4291715
- Barsanti, P. A., Pan, Y., Lu, Y., Jain, R., Cox, M., Aversa, R. J., Dillon, M. P., Ening, R., Hu, C., Jin, X., Knapp, M., Lan, J., et al. Structure-based drug design of novel, potent, and selective azabenzimidazoles (ABI) as ATR inhibitors ACS Medicinal Chemistry Letters 2015 6:42-46 DOI:10.1021/ml500352s PMID:25589928 PMCID:PMC4291699
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Nicolaou, K. C.*, Aversa, R. J.*
Maitotoxin: An inspiration for synthesis
Israel Journal of Chemistry
2011
51:359-377
DOI:10.1002/ijch.201100003
PMID:21709816
PMCID:PMC3119573
(* = equal contribution)
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Nicolaou, K. G., Seo, J. H., Nakamura, T., Aversa, R. J.
Synthesis of the C′D′E′F′ domain of maitotoxin
Journal of the American Chemical Society
2011
133:214-219
DOI:10.1021/ja109531d
PMID:21166429
PMCID:PMC3132320
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Nicolaou, K. C.*, Aversa, R. J.*, Jin, J., Rivas, F.
Synthesis of the ABCDEFG ring system of maitotoxin
Journal of the American Chemical Society
2010
132:6855-6861
DOI:10.1021/ja102260q
PMID:20415445
PMCID:PMC2880607
(* = equal contribution)
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Nicolaou, K. C.*, Frederick, M. O.*, Burtoloso, A. C. B., Denton, R. M., Rivas, F., Cole, K. P., Aversa, R. J., Gibe, R., Umezawa, T., Suzuki, T.
Chemical synthesis of the GHIJKLMNO ring system of maitotoxin
Journal of the American Chemical Society
2008
130:7466-7476
DOI:10.1021/ja801139f
PMID:18481856
(* = equal contribution)
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Nicolaou, K. C.*, Frederick, M. O.*, Aversa, R. J.
The continuing saga of the marine polyether biotoxins
Angewandte Chemie-International Edition
2008
47:7182-7225
DOI:10.1002/anie.200801696
PMID:18763702
PMCID:PMC2730226
(* = equal contribution)
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Nicolaou, K. C., Cole, K. P., Frederick, M. O., Aversa, R. J., Denton, R. M.
Chemical synthesis of the GHIJK ring system and further experimental support for the originally assigned structure of maitotoxin
Angewandte Chemie-International Edition
2007
46:8875-8879
DOI:10.1002/anie.200703742
PMID:17943950