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Aversa, Robert
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Aversa, Robert

Graduate Student
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Positions

  • 2016 - Investigator III, Cambridge, Massachusetts, Novartis Institutes for BioMedical Research
  • 2014 - 2016 Investigator II, Cambridge, Massachusetts, Novartis Institutes for BioMedical Research
  • 2011 - 2014 Investigator II, Emeryville, California, Novartis Institutes for BioMedical Research
  • 2005 Medicinal Chemistry Intern, Amgen

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Publications

recent publications
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  • academic article

    • Nishiguchi, G. A., Rico, A., Tanner, H., Aversa, R. J., Taft, B. R., Subramanian, S., Setti, L., Burger, M. T., Wan, L. F., Tamez, V., Smith, A., Lou, Y., et al. Design and discovery of N-(2-Methyl-5 '-morpholino-6 '-((tetrahydro-2H-pyran-4-yl)oxy)- 3,3 '-bipyridin -5-yl)-3-(trifluoromethyl)benzamide (RAF709): a potent, selective, and efficacious RAF inhibitor targeting RAS mutant cancers Journal of Medicinal Chemistry  2017 60:4869-4881  DOI:10.1021/acs.jmedchem.6b01862  PMID:28557458
    • Barsanti, P. A., Aversa, R. J., Jin, X., Pan, Y., Lu, Y., Elling, R., Jain, R., Knapp, M., Lan, J., Lin, X., Rudewicz, P., Sim, J., et al. Structure-based drug design of novel potent and selective tetrahydropyrazolo 1,5-a pyrazines as ATR inhibitors ACS Medicinal Chemistry Letters  2015 6:37-41  DOI:10.1021/ml500353p  PMID:25589927  PMCID:PMC4291715
    • Barsanti, P. A., Pan, Y., Lu, Y., Jain, R., Cox, M., Aversa, R. J., Dillon, M. P., Ening, R., Hu, C., Jin, X., Knapp, M., Lan, J., et al. Structure-based drug design of novel, potent, and selective azabenzimidazoles (ABI) as ATR inhibitors ACS Medicinal Chemistry Letters  2015 6:42-46  DOI:10.1021/ml500352s  PMID:25589928  PMCID:PMC4291699
    • degree-related publication Nicolaou, K. C.*, Aversa, R. J.* Maitotoxin: An inspiration for synthesis Israel Journal of Chemistry  2011 51:359-377  DOI:10.1002/ijch.201100003  PMID:21709816  PMCID:PMC3119573 (* = equal contribution)
    • degree-related publication Nicolaou, K. G., Seo, J. H., Nakamura, T., Aversa, R. J. Synthesis of the C′D′E′F′ domain of maitotoxin Journal of the American Chemical Society  2011 133:214-219  DOI:10.1021/ja109531d  PMID:21166429  PMCID:PMC3132320
    • degree-related publication Nicolaou, K. C.*, Aversa, R. J.*, Jin, J., Rivas, F. Synthesis of the ABCDEFG ring system of maitotoxin Journal of the American Chemical Society  2010 132:6855-6861  DOI:10.1021/ja102260q  PMID:20415445  PMCID:PMC2880607 (* = equal contribution)
    • degree-related publication Nicolaou, K. C.*, Frederick, M. O.*, Burtoloso, A. C. B., Denton, R. M., Rivas, F., Cole, K. P., Aversa, R. J., Gibe, R., Umezawa, T., Suzuki, T. Chemical synthesis of the GHIJKLMNO ring system of maitotoxin Journal of the American Chemical Society  2008 130:7466-7476  DOI:10.1021/ja801139f  PMID:18481856 (* = equal contribution)
    • degree-related publication Nicolaou, K. C.*, Frederick, M. O.*, Aversa, R. J. The continuing saga of the marine polyether biotoxins Angewandte Chemie-International Edition  2008 47:7182-7225  DOI:10.1002/anie.200801696  PMID:18763702  PMCID:PMC2730226 (* = equal contribution)
    • degree-related publication Nicolaou, K. C., Cole, K. P., Frederick, M. O., Aversa, R. J., Denton, R. M. Chemical synthesis of the GHIJK ring system and further experimental support for the originally assigned structure of maitotoxin Angewandte Chemie-International Edition  2007 46:8875-8879  DOI:10.1002/anie.200703742  PMID:17943950
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Background

education and training

  • Ph.D. in Synthetic Chemistry, Scripps Research 2006 - 2011
  • B.A. in Chemistry & Biochemistry, Cornell University 2002 - 2006

advisee of

  • graduate advising relationship

    • Nicolaou, K.C., Ph.D.  candidacy, 2007 - 2011
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Contact

full name

  • Robert John Aversa

geographic location

  • Scripps California 

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