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Asahara, Hiroshi
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Asahara, Hiroshi

Faculty Member
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Positions

  • 2017 - Professor of Molecular Medicine, Molecular Medicine , Scripps Research
  • 2015 - 2017 Professor of Molecular and Experimental Medicine, Molecular and Experimental Medicine (MEM) , Scripps Research
  • 2008 - 2015 Associate Professor of Molecular and Experimental Medicine, Molecular and Experimental Medicine (MEM) , Scripps Research
  • 2002 - 2008 Assistant Professor of Molecular and Experimental Medicine, Molecular and Experimental Medicine (MEM) , Scripps Research
  • 2000 - 2002 Staff Scientist, Salk Institute for Biological Studies
  • - 2000 Postdoctoral Fellow, Salk Institute for Biological Studies
  • - 1999 Postdoctoral Fellow, Harvard Medical School, Harvard University
Dr. Hiroshi Asahara is a molecular biologist and orthopedic surgeon who examines the precise mechanism of chromatin-dependent gene regulation, combining new findings in molecular and developmental biology with clinical research in the field of locomotive science to develop innovative new therapies for patients with arthritis, bone tumor and spinal cord injuries.

Research Areas research areas

  • Arthritis (UMLS)

Contact

  • asahara@scripps.edu

Websites

  • Hiroshi Asahara, M.D., Ph.D
  • Laboratory Website
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Publications

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    • Nakamichi, R., Kurimoto, R., Tabata, Y., Asahara, H. Transcriptional, epigenetic and microRNA regulation of growth plate Bone  2020 137  DOI:10.1016/j.bone.2020.115434  PMID:32422296  PMCID:PMC7387102
    • Kataoka, K., Kurimoto, R., Tsutsumi, H., Chiba, T., Shishido, K., Kato, M., Ito, Y., Cho, Y., Hoshi, O., Mimata, A., Sakamaki, Y., Nakamichi, R. In vitro Neo-Genesis of Tendon/Ligament-Like Tissue by Combination of Mohawk and a Three-Dimensional Cyclic Mechanical Stretch Culture System Frontiers in Cell and Developmental Biology  2020 8  DOI:10.3389/fcell.2020.00307  PMID:32671057  PMCID:PMC7326056
    • Gracey, E., Burssens, A., Cambre, I., Schett, G., Lories, R., McInnes, I. B., Asahara, H., Elewaut, D. Tendon and ligament mechanical loading in the pathogenesis of inflammatory arthritis Nature Reviews Rheumatology  2020  DOI:10.1038/s41584-019-0364-x  PMID:32080619
    • Lee, K. I., Gamini, R., Olmer, M., Ikuta, Y., Hasei, J., Baek, J., Alvarez-Garcia, O., Grogan, S. P., D'Lima, D., Asahara, H., Su, A. I., Lotz, M. K. Mohawk is a transcription factor that promotes meniscus cell phenotype and tissue repair and reduces osteoarthritis severity Science Translational Medicine  2020 12  DOI:10.1126/scitranslmed.aan7967  PMID:33115953  PMCID:PMC7955769
    • Kurimoto, R., Chiba, T., Ito, Y., Matsushima, T., Yano, Y., Miyata, K., Yashiro, Y., Suzuki, T., Tomita, K., Asahara, H. The tRNA pseudouridine synthase TruB1 regulates the maturation of let-7 miRNA EMBO Journal  2020 39  DOI:10.15252/embj.2020104708  PMID:32926445  PMCID:PMC7560213
    • Yamashita, S., Kataoka, K., Yamamoto, H., Kato, T., Hara, S., Yamaguchi, K., Renard-Guillet, C., Katou, Y., Shirahige, K., Ochi, H., Ogino, H., Uchida, T., et al. Comparative analysis demonstrates cell type-specific conservation of SOX9 targets between mouse and chicken Scientific Reports  2019 9  DOI:10.1038/s41598-019-48979-4  PMID:31467356  PMCID:PMC6715657
    • Alvarez-Garcia, O., Matsuzaki, T., Olmer, M., Miyata, K., Mokuda, S., Sakai, D., Masuda, K., Asahara, H., Lotz, M. K. FOXO are required for intervertebral disk homeostasis during aging and their deficiency promotes disk degeneration Aging Cell  2018 17  DOI:10.1111/acel.12800  PMID:29963746  PMCID:PMC6156454
    • Mochizuki, Y., Chiba, T., Kataoka, K., Yamashita, S., Sato, T., Kato, T., Takahashi, K., Miyamoto, T., Kitazawa, M., Hatta, T., Natsume, T., Takai, S., et al. Combinatorial CRISPR/Cas9 approach to elucidate a far-upstream enhancer complex for tissue-specific Sox9 expression Developmental Cell  2018 46:794-806  DOI:10.1016/j.devcel.2018.07.024  PMID:30146478
    • Inui, M., Mokuda, S., Sato, T., Tamano, M., Takada, S., Asahara, H. Dissecting the roles of miR-140 and its host gene Nature Cell Biology  2018 20:516-518  DOI:10.1038/s41556-018-0077-4  PMID:29695789
    • Matsuzaki, T., Alvarez-Garcia, O., Mokuda, S., Nagira, K., Olmer, M., Gamini, R., Miyata, K., Akasaki, Y., Su, A. I., Asahara, H., Lotz, M. K. FoxO transcription factors modulate autophagy and proteoglycan 4 in cartilage homeostasis and osteoarthritis Science Translational Medicine  2018 10:eaan0746  DOI:10.1126/scitranslmed.aan0746  PMID:29444976
    • Nakamichi, R., Kataoka, K., Asahara, H. Essential role of Mohawk for tenogenic tissue homeostasis including spinal disc and periodontal ligament Modern Rheumatology  2018 28:933-940  DOI:10.1080/14397595.2018.1466644  PMID:29667905
    • Okuda, K., Kobayashi, S., Fukaya, M., Watanabe, A., Murakami, T., Hagiwara, M., Sato, T., Ueno, H., Ogonuki, N., Komano-Inoue, S., Manabe, H., Yamaguchi, M., et al. CDKL5 controls postsynaptic localization of GluN2B-containing NMDA receptors in the hippocampus and regulates seizure susceptibility Neurobiology of Disease  2017 106:158-170  DOI:10.1016/j.nbd.2017.07.002  PMID:28688852
    • Asahara, H., Inui, M., Lotz, M. K. Tendons and ligaments: connecting developmental biology to musculoskeletal disease pathogenesis Journal of Bone and Mineral Research  2017 32:1773-1782  DOI:10.1002/jbmr.3199  PMID:28621492
    • Yokoyama, S., Furukawa, S., Kitada, S., Mori, M., Saito, T., Kawakami, K., Belmonte, J. C. I., Kawakami, Y., Ito, Y., Sato, T., Asahara, H. Analysis of transcription factors expressed at the anterior mouse limb bud PLoS One  2017 12  DOI:10.1371/journal.pone.0175673  PMID:28467430  PMCID:PMC5415108
    • Ito, Y., Inoue, A., Seers, T., Hato, Y., Igarashi, A., Toyama, T., Taganov, K. D., Boldin, M. P., Asahara, H. Identification of targets of tumor suppressor microRNA-34a using a reporter library system Proceedings of the National Academy of Sciences of the United States of America  2017 114:3927-3932  DOI:10.1073/pnas.1620019114  PMID:28356515  PMCID:PMC5393199
    • Hasei, J., Teramura, T., Takehara, T., Onodera, Y., Horii, T., Olmer, M., Hatada, I., Fukuda, K., Ozaki, T., Lotz, M. K., Asahara, H. TWIST1 induces MMP3 expression through up-regulating DNA hydroxymethylation and promotes catabolic responses in human chondrocytes Scientific Reports  2017 7  DOI:10.1038/srep42990  PMID:28220902  PMCID:PMC5318945
    • Koda, N., Sato, T., Shinohara, M., Ichinose, S., Ito, Y., Nakamichi, R., Kayama, T., Kataoka, K., Suzuki, H., Moriyama, K., Asahara, H. The transcription factor mohawk homeobox regulates homeostasis of the periodontal ligament Development  2017 144:313-320  DOI:10.1242/dev.135798  PMID:27993989
    • Nakasuji, T., Ogonuki, N., Chiba, T., Kato, T., Shiozawa, K., Yamatoya, K., Tanaka, H., Kondo, T., Miyado, K., Miyasaka, N., Kubota, T., Ogura, A., et al. Complementary critical functions of Zfy1 and Zfy2 in mouse spermatogenesis and reproduction PLoS Genetics  2017 13  DOI:10.1371/journal.pgen.1006578  PMID:28114340  PMCID:PMC5287576
    • Nakamichi, R., Ito, Y., Inui, M., Onizuka, N., Kayama, T., Kataoka, K., Suzuki, H., Mori, M., Inagawa, M., Ichinose, S., Lotz, M. K., Sakai, D., et al. Mohawk promotes the maintenance and regeneration of the outer annulus fibrosus of intervertebral discs Nature Communications  2016 7  DOI:10.1038/ncomms12503  PMID:27527664  PMCID:PMC4990710
    • Suzuki, H., Ito, Y., Shinohara, M., Yamashita, S., Ichinose, S., Kishida, A., Oyaizu, T., Kayama, T., Nakamichi, R., Koda, N., Yagishita, K., Lotz, M. K., et al. Gene targeting of the transcription factor Mohawk in rats causes heterotopic ossification of Achilles tendon via failed tenogenesis Proceedings of the National Academy of Sciences of the United States of America  2016 113:7840-7845  DOI:10.1073/pnas.1522054113  PMID:27370800  PMCID:PMC4948356
    • Shimbo, M., Kudo, T., Hamada, M., Jeon, H., Imamura, Y., Asano, K., Okada, R., Tsunakawa, Y., Mizuno, S., Yagami, K., Ishikawa, C., Li, H., et al. Ground-based assessment of JAXA mouse habitat cage unit by mouse phenotypic studies Experimental Animals  2016 65:175-187  PMID:26822934  PMCID:PMC4873486
    • Kayama, T., Mori, M., Ito, Y., Matsushima, T., Nakamichi, R., Suzuki, H., Ichinose, S., Saito, M., Marumo, K., Asahara, H. Gtf2ird1-dependent mohawk expression regulates mechanosensing properties of the tendon Molecular and Cellular Biology  2016 36:1297-1309  DOI:10.1128/mcb.00950-15  PMID:26884464
    • Doiguchi, M., Nakagawa, T., Imamura, Y., Yoneda, M., Higashi, M., Kubota, K., Yamashita, S., Asahara, H., Iida, M., Fujii, S., Ikura, T., Liu, Z. Y., et al. SMARCAD1 is an ATP-dependent stimulator of nucleosomal H2A acetylation via CBP, resulting in transcriptional regulation Scientific Reports  2016 6  DOI:10.1038/srep20179  PMID:26888216  PMCID:PMC4757861
    • Asahara, H. Current status and strategy of microRNA research for cartilage development and osteoarthritis pathogenesis Journal of Bone Metabolism  2016 23:121-127  DOI:10.11005/jbm.2016.23.3.121  PMID:27622175  PMCID:PMC5018604
    • Naito, M., Mori, M., Inagawa, M., Miyata, K., Hashimoto, N., Tanaka, S., Asahara, H. Dnmt3a regulates proliferation of muscle satellite cells via p57Kip2 PLoS Genetics  2016 12  DOI:10.1371/journal.pgen.1006167  PMID:27415617  PMCID:PMC4944932
    • Otero, M., Peng, H., El Hachem, K., Culley, K. L., Wondimu, E. B., Quinn, J., Asahara, H., Tsuchimochi, K., Hashimoto, K., Goldring, M. B. ELF3 modulates type II collagen gene (COL2A1) transcription in chondrocytes by inhibiting SOX9-CBP/p300-driven histone acetyltransferase activity Connective Tissue Research  2016 58:1-12  DOI:10.1080/03008207.2016.1200566  PMID:27310669  PMCID:PMC5326708
    • Craney, A., Gernapudi, R., Yao, Y., Wolfson, B., Zhang, Y., Craney, A., Yao, Y., Yang, P., Asahara, H., Zhou, Q. MicroRNA 140 promotes expression of long noncoding RNA NEAT1 in adipogenesis Molecular and Cellular Biology  2016 36:30-38  DOI:10.1128/mcb.00702-15  PMID:26459763
    • Ogura, Y., Miyake, N., Kou, I., Iida, A., Nakajima, M., Takeda, K., Fujibayashi, S., Shiina, M., Okada, E., Toyama, Y., Iwanami, A., Ishii, K., et al. Identification of HOXD4 mutations in spinal extradural arachnoid cyst PLoS One  2015 10  DOI:10.1371/journal.pone.0142126  PMID:26545093  PMCID:PMC4636324
    • Tateishi, R., Akiyama, N., Miyauchi, M., Yoshinaga, R., Sasanuma, H., Kudo, T., Shimbo, M., Shinohara, M., Obata, K., Inoue, J., Shirakawa, M., Shiba, D., et al. Hypergravity provokes a temporary reduction in CD4+CD8+thymocyte number and a persistent decrease in medullary thymic epithelial cell frequency in mice PLoS One  2015 10  DOI:10.1371/journal.pone.0141650  PMID:26513242  PMCID:PMC4626100
    • Matsubara, Y., Kato, T., Kashimada, K., Tanaka, H., Zhi, Z., Ichinose, S., Mizutani, S., Morio, T., Chiba, T., Ito, Y., Saga, Y., Takada, S., et al. TALEN-mediated gene disruption on Y chromosome reveals critical role of EIF2S3Y in mouse spermatogenesis Stem Cells and Development  2015 24:1164-1170  DOI:10.1089/scd.2014.0466  PMID:25579647  PMCID:PMC4425228
    • Miyata, K., Miyata, T., Nakabayashi, K., Okamura, K., Naito, M., Kawai, T., Takada, S., Kato, K., Miyamoto, S., Hata, K., Asahara, H. DNA methylation analysis of human myoblasts during in vitro myogenic differentiation: de novo methylation of promoters of muscle-related genes and its involvement in transcriptional down-regulation Human Molecular Genetics  2015 24:410-423  DOI:10.1093/hmg/ddu457  PMID:25190712  PMCID:PMC4275072
    • Otabe, K., Nakahara, H., Hasegawa, A., Matsukawa, T., Ayabe, F., Onizuka, N., Inui, M., Takada, S., Ito, Y., Sekiya, I., Muneta, T., Lotz, M., et al. Transcription factor Mohawk controls tenogenic differentiation of bone marrow mesenchymal stem cells in vitro and in vivo Journal of Orthopaedic Research  2015 33:1-8  DOI:10.1002/jor.22750  PMID:25312837  PMCID:PMC4294629
    • Nagata, E., Kano, H., Kato, F., Yamaguchi, R., Nakashima, S., Takayama, S., Kosaki, R., Tonoki, H., Mizuno, S., Watanabe, S., Yoshiura, K. I., Kosho, T., et al. Japanese founder duplications/triplications involving BHLHA9 are associated with split-hand/foot malformation with or without long bone deficiency and Gollop-Wolfgang complex Orphanet Journal of Rare Diseases  2014 9  DOI:10.1186/s13023-014-0125-5  PMID:25351291  PMCID:PMC4205278
    • Miyata, K., Yotsumoto, F., Nam, S. O., Odawara, T., Manabe, S., Ishikawa, T., Itamochi, H., Kigawa, J., Takada, S., Asahara, H., Kuroki, M., Miyamoto, S. Contribution of transcription factor, SP1, to the promotion of HB-EGF expression in defense mechanism against the treatment of irinotecan in ovarian clear cell carcinoma Cancer Medicine  2014 3:1159-1169  DOI:10.1002/cam4.301  PMID:25060396  PMCID:PMC4302667
    • Inui, M., Miyado, M., Igarashi, M., Tamano, M., Kubo, A., Yamashita, S., Asahara, H., Fukami, M., Takada, S. Rapid generation of mouse models with defined point mutations by the CRISPR/Cas9 system Scientific Reports  2014 4:5396  DOI:10.1038/srep05396  PMID:24953798  PMCID:PMC4066261
    • Matsubara, Y., Chiba, T., Kashimada, K., Morio, T., Takada, S., Mizutani, S., Asahara, H. Transcription activator-like effector nuclease-mediated transduction of exogenous gene into IL2RG locus Scientific Reports  2014 4:5043  DOI:10.1038/srep05043  PMID:24853770  PMCID:PMC4031469
    • Takasawa, K., Kashimada, K., Pelosi, E., Takagi, M., Morio, T., Asahara, H., Schlessinger, D., Mizutani, S., Koopman, P. FOXL2 transcriptionally represses Sf1 expression by antagonizing WT1 during ovarian development in mice FASEB Journal  2014 28:2020-2028  DOI:10.1096/fj.13-246108  PMID:24451388  PMCID:PMC3986836
    • Shinohara, M., Chang, B. Y., Buggy, J. J., Nagai, Y., Kodama, T., Asahara, H., Takayanagi, H. The orally available Btk inhibitor ibrutinib (PCI-32765) protects against osteoclast-mediated bone loss Bone  2014 60:8-15  DOI:10.1016/j.bone.2013.11.025  PMID:24316417
    • Akasaki, Y., Hasegawa, A., Saito, M., Asahara, H., Iwamoto, Y., Lotz, M. K. Dysregulated FOXO transcription factors in articular cartilage in aging and osteoarthritis Osteoarthritis and Cartilage  2014 22:162-170  DOI:10.1016/j.joca.2013.11.004  PMID:24269635  PMCID:PMC3932989
    • Onizuka, N., Ito, Y., Inagawa, M., Nakahara, H., Takada, S., Lotz, M., Toyama, Y., Asahara, H. The Mohawk homeobox transcription factor regulates the differentiation of tendons and volar plates Journal of Orthopaedic Science  2014 19:172-180  DOI:10.1007/s00776-013-0485-z  PMID:24166359  PMCID:PMC3943675
    • Yoshitaka, T., Kawai, A., Miyaki, S., Numoto, K., Kikuta, K., Ozaki, T., Lotz, M., Asahara, H. Analysis of microRNAs expressions in chondrosarcoma Journal of Orthopaedic Research  2013 31:1992-1998  DOI:10.1002/jor.22457  PMID:23940002  PMCID:PMC3835201
    • Kato, T., Miyata, K., Sonobe, M., Yamashita, S., Tamano, M., Miura, K., Kanai, Y., Miyamoto, S., Sakuma, T., Yamamoto, T., Inui, M., Kikusui, T., et al. Production of Sry knockout mouse using TALEN via oocyte injection Scientific Reports  2013 3  DOI:10.1038/srep03136  PMID:24190364  PMCID:PMC3817445
    • Takada, S., Sato, T., Ito, Y., Yamashita, S., Kato, T., Kawasumi, M., Kanai-Azuma, M., Igarashi, A., Kato, T., Tamano, M., Asahara, H. Targeted gene deletion of miRNAs in mice by TALEN system PLoS One  2013 8:e76004  DOI:10.1371/journal.pone.0076004  PMID:24146809  PMCID:PMC3797721
    • Shimizu, H., Kubo, A., Uchibe, K., Hashimoto, M., Yokoyama, S., Takada, S., Mitsuoka, K., Asahara, H. The AERO system: a 3D-like approach for recording gene expression patterns in the whole mouse embryo PLoS One  2013 8  DOI:10.1371/journal.pone.0075754  PMID:24146773  PMCID:PMC3797748
    • Gibson, G., Asahara, H. microRNAs and cartilage Journal of Orthopaedic Research  2013 31:1333-1344  DOI:10.1002/jor.22397  PMID:23754477
    • Nakahara, H., Hasegawa, A., Otabe, K., Ayabe, F., Matsukawa, T., Onizuka, N., Ito, Y., Ozaki, T., Lotz, M. K., Asahara, H. Transcription factor Mohawk and the pathogenesis of human anterior cruciate ligament degradation Arthritis and Rheumatism  2013 65:2081-2089  DOI:10.1002/art.38020  PMID:23686683  PMCID:PMC3840305
    • Rakoczy, J., Fernandez-Valverde, S. L., Glazov, E. A., Wainwright, E. N., Sato, T., Takada, S., Combes, A. N., Korbie, D. J., Miller, D., Grimmond, S. M., Little, M. H., Asahara, H., et al. MicroRNAs-140-5p/140-3p modulate Leydig cell numbers in the developing mouse testis Biology of Reproduction  2013 88  DOI:10.1095/biolreprod.113.107607  PMID:23616593
    • Furumatsu, T., Asahara, H. Chromatin assembly and in vitro transcription analyses for evaluation of individual protein activities in multicomponent transcriptional complexes Methods in Molecular Biology  2013 977:193-202  DOI:10.1007/978-1-62703-284-1_15  PMID:23436363
    • Hasegawa, A., Nakahara, H., Kinoshita, M., Asahara, H., Koziol, J., Lotz, M. K. Cellular and extracellular matrix changes in anterior cruciate ligaments during human knee aging and osteoarthritis Arthritis Research & Therapy  2013 15:R29  DOI:10.1186/ar4165  PMID:23406989  PMCID:PMC3672799
    • Watanabe, T., Oyama, T., Asada, M., Harada, D., Ito, Y., Inagawa, M., Suzuki, Y., Sugano, S., Katsube, K., Karsenty, G., Komori, T., Kitagawa, M., et al. MAML1 enhances the transcriptional activity of Runx2 and plays a role in bone development PLoS Genetics  2013 9:e1003132  DOI:10.1371/journal.pgen.1003132  PMID:23326237  PMCID:PMC3542067
    • Matsukawa, T., Sakai, T., Yonezawa, T., Hiraiwa, H., Hamada, T., Nakashima, M., Ono, Y., Ishizuka, S., Nakahara, H., Lotz, M. K., Asahara, H., Ishiguro, N. MicroRNA-125b regulates the expression of aggrecanase-1 (ADAMTS-4) in human osteoarthritic chondrocytes Arthritis Research & Therapy  2013 15:R28  DOI:10.1186/ar4164  PMID:23406982  PMCID:PMC3672767
    • Takata, A., Otsuka, M., Yoshikawa, T., Kishikawa, T., Hikiba, Y., Obi, S., Goto, T., Kang, Y. J., Maeda, S., Yoshida, H., Omata, M., Asahara, H., et al. MicroRNA-140 acts as a liver tumor suppressor by controlling NF-kappaB activity by directly targeting DNA methyltransferase 1 (Dnmt1) expression Hepatology  2013 57:162-170  DOI:10.1002/hep.26011  PMID:22898998  PMCID:PMC3521841
    • Takada, S., Asahara, H. Current strategies for microRNA research Modern Rheumatology  2012 22:645-653  DOI:10.1007/s10165-011-0583-8  PMID:22237764
    • Miyaki, S., Asahara, H. Macro view of microrna function in osteoarthritis Nature Reviews Rheumatology  2012 8:543-552  DOI:10.1038/nrrheum.2012.128  PMID:22890245  PMCID:PMC3572197
    • Fukami, M., Tsuchiya, T., Takada, S., Kanbara, A., Asahara, H., Igarashi, A., Kamiyama, Y., Nishimura, G., Ogata, T. Complex genomic rearrangement in the SOX9 5' region in a patient with Pierre Robin sequence and hypoplastic left scapula American Journal of Medical Genetics Part A  2012 158A:1529-1534  DOI:10.1002/ajmg.a.35308  PMID:22529047
    • Uchibe, K., Shimizu, H., Yokoyama, S., Kuboki, T., Asahara, H. Identification of novel transcription-regulating genes expressed during murine molar development Developmental Dynamics  2012 241:1217-1226  DOI:10.1002/dvdy.23808  PMID:22639370
    • Yamashita, S., Miyaki, S., Kato, Y., Yokoyama, S., Sato, T., Barrionuevo, F., Akiyama, H., Scherer, G., Takada, S., Asahara, H. L-Sox5 and Sox6 proteins enhance chondrogenic miR-140 microRNA expression by strengthening dimeric Sox9 activity Journal of Biological Chemistry  2012 287:22206-22215  DOI:10.1074/jbc.M112.343194  PMID:22547066  PMCID:PMC3381182
    • Chan, E. F., Harjanto, R., Asahara, H., Inoue, N., Masuda, K., Bugbee, W. D., Firestein, G. S., Hosalkar, H. S., Lotz, M. K., Sah, R. L. Structural and functional maturation of distal femoral cartilage and bone during postnatal development and growth in humans and mice Orthopedic Clinics of North America  2012 43:173-85  DOI:10.1016/j.ocl.2012.01.005  PMID:22480467  PMCID:PMC3321216
    • Ito, Y., Kayama, T., Asahara, H. A systems approach and skeletal myogenesis Comparative and Functional Genomics  2012 759407  DOI:10.1155/2012/759407  PMID:22991503  PMCID:PMC3443578
    • Wada, S., Kato, Y., Okutsu, M., Miyaki, S., Suzuki, K., Yan, Z., Schiaffino, S., Asahara, H., Ushida, T., Akimoto, T. Translational suppression of atrophic regulators by microRNA-23a integrates resistance to skeletal muscle atrophy Journal of Biological Chemistry  2011 286:38456-38465  DOI:10.1074/jbc.M111.271270  PMID:21926429  PMCID:PMC3207415
    • Asahara, H. Switching gears to an arthritis gene expression network by SirT1 cleavage Arthritis and Rheumatism  2011 63:2161-2163  DOI:10.1002/art.30276  PMID:21305531
    • Yokoyama, S., Asahara, H. The myogenic transcriptional network Cellular and Molecular Life Sciences  2011 68:1843-1849  DOI:10.1007/s00018-011-0629-2  PMID:21318263  PMCID:PMC3092062
    • Awazawa, M., Ueki, K., Inabe, K., Yamauchi, T., Kubota, N., Kaneko, K., Kobayashi, M., Iwane, A., Sasako, T., Okazaki, Y., Ohsugi, M., Takamoto, I., et al. Adiponectin enhances insulin sensitivity by increasing hepatic IRS-2 expression via a macrophage-derived IL-6-dependent pathway Cell Metabolism  2011 13:401-412  DOI:10.1016/j.cmet.2011.02.010  PMID:21459325
    • Asada, M., Rauch, A., Shimizu, H., Maruyama, H., Miyaki, S., Shibamori, M., Kawasome, H., Ishiyama, H., Tuckermann, J., Asahara, H. DNA binding-dependent glucocorticoid receptor activity promotes adipogenesis via Kruppel-like factor 15 gene expression Laboratory Investigation  2011 91:203-215  DOI:10.1038/labinvest.2010.170  PMID:20956975  PMCID:PMC3025047
    • Mizutani, R., Nakamura, K., Yokoyama, S., Sanbe, A., Kusakawa, S., Miyamoto, Y., Torii, T., Asahara, H., Okado, H., Yamauchi, J., Tanoue, A. Developmental expression of sorting nexin 3 in the mouse central nervous system Gene Expression Patterns  2011 11:33-40  DOI:10.1016/j.gep.2010.08.007  PMID:20817026
    • Furumatsu, T., Asahara, H. Histone acetylation influences the activity of Sox9-related transcriptional complex Acta Medica Okayama  2010 64:351-357  PMID:21173804
    • Ito, Y., Toriuchi, N., Yoshitaka, T., Ueno-Kudoh, H., Sato, T., Yokoyama, S., Nishida, K., Akimoto, T., Takahashi, M., Miyaki, S., Asahara, H. The Mohawk homeobox gene is a critical regulator of tendon differentiation Proceedings of the National Academy of Sciences of the United States of America  2010 107:10538-10542  DOI:10.1073/pnas.1000525107  PMID:20498044  PMCID:PMC2890854
    • Otsuki, S., Hanson, S. R., Miyaki, S., Grogan, S. P., Kinoshita, M., Asahara, H., Wong, C. H., Lotz, M. K. Extracellular sulfatases support cartilage homeostasis by regulating BMP and FGF signaling pathways Proceedings of the National Academy of Sciences of the United States of America  2010 107:10202-10207  DOI:10.1073/pnas.0913897107  PMID:20479257  PMCID:PMC2890424
    • Miyaki, S., Sato, T., Inoue, A., Otsuki, S., Ito, Y., Yokoyama, S., Kato, Y., Takemoto, F., Nakasa, T., Yamashita, S., Takada, S., Lotz, M. K., et al. MicroRNA-140 plays dual roles in both cartilage development and homeostasis Genes & Development  2010 24:1173-1185  DOI:10.1101/gad.1915510  PMID:20466812  PMCID:PMC2878654
    • Nakanishi, K., Nakasa, T., Tanaka, N., Ishikawa, M., Yamada, K., Yamasaki, K., Kamei, N., Izumi, B., Adachi, N., Miyaki, S., Asahara, H., Ochi, M. Responses of microRNAs 124a and 223 following spinal cord injury in mice Spinal Cord  2010 48:192-196  DOI:10.1038/sc.2009.89  PMID:19621023
    • Higashiyama, R., Miyaki, S., Yamashita, S., Yoshitaka, T., Lindman, G., Ito, Y., Sasho, T., Takahashi, K., Lotz, M., Asahara, H. Correlation between MMP-13 and HDAC7 expression in human knee osteoarthritis Modern Rheumatology  2010 20:11-17  DOI:10.1007/s10165-009-0224-7  PMID:19784544  PMCID:PMC2818344
    • Otsuki, S., Grogan, S. P., Miyaki, S., Kinoshita, M., Asahara, H., Lotz, M. K. Tissue neogenesis and STRO-1 expression in immature and mature articular cartilage Journal of Orthopaedic Research  2010 28:96-102  DOI:10.1002/jor.20944  PMID:19603515  PMCID:PMC2905317
    • Yokoyama, S., Ito, Y., Ueno-Kudoh, H., Shimizu, H., Uchibe, K., Albini, S., Mitsuoka, K., Miyaki, S., Kiso, M., Nagai, A., Hikata, T., Osada, T., et al. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58 Developmental Cell  2009 17:836-848  DOI:10.1016/j.devcel.2009.10.011  PMID:20059953  PMCID:PMC3110151
    • Kumagishi, K., Nishida, K., Yamaai, T., Momota, R., Miyaki, S., Hirohata, S., Naito, I., Asahara, H., Ninomiya, Y., Ohtsuka, A. A disintegrin and metalloproteinase with thrombospondin motifs 9 (ADAMTS9) expression by chondrocytes during endochondral ossification Archives of Histology and Cytology  2009 72:175-185  DOI:10.1679/aohc.72.175  PMID:20513980
    • Kato, Y., Miyaki, S., Yokoyama, S., Omori, S., Inoue, A., Horiuchi, M., Asahara, H. Real-time functional imaging for monitoring miR-133 during myogenic differentiation International Journal of Biochemistry & Cell Biology  2009 41:2225-2231  DOI:10.1016/j.biocel.2009.04.018  PMID:19398036  PMCID:PMC2806093
    • Abe, Y., Oka, A., Mizuguchi, M., Igarashi, T., Ishikawa, S., Aburatani, H., Yokoyama, S., Asahara, H., Nagao, K., Yamada, M., Miyashita, T. EYA4, deleted in a case with middle interhemispheric variant of holoprosencephaly, interacts with SIX3 both physically and functionally Human Mutation  2009 30:E946-E955  DOI:10.1002/humu.21094  PMID:19606496
    • Ito, T., Yadav, N., Lee, J., Furumatsu, T., Yamashita, S., Yoshida, K., Taniguchi, N., Hashimoto, M., Tsuchiya, M., Ozaki, T., Lotz, M., Bedford, M. T., et al. Arginine methyltransferase CARM1/PRMT4 regulates endochondral ossification BMC Developmental Biology  2009 9:47  DOI:10.1186/1471-213x-9-47  PMID:19725955  PMCID:PMC2754437
    • Nagata, Y., Nakasa, T., Mochizuki, Y., Ishikawa, M., Miyaki, S., Shibuya, H., Yamasaki, K., Adachi, N., Asahara, H., Ochi, M. Induction of apoptosis in the synovium of mice with autoantibody-mediated arthritis by the intraarticular injection of double-stranded microRNA-15a Arthritis and Rheumatism  2009 60:2677-2683  DOI:10.1002/art.24762  PMID:19714650
    • Miyaki, S., Nakasa, T., Otsuki, S., Grogan, S. P., Higashiyama, R., Inoue, A., Kato, Y., Sato, T., Lotz, M. K., Asahara, H. MicroRNA-140 is expressed in differentiated human articular chondrocytes and modulates interleukin-1 responses Arthritis and Rheumatism  2009 60:2723-2730  DOI:10.1002/art.24745  PMID:19714579  PMCID:PMC2806094
    • Yamashita, S., Andoh, M., Ueno-Kudoh, H., Sato, T., Miyaki, S., Asahara, H. Sox9 directly promotes Bapx1 gene expression to repress Runx2 in chondrocytes Experimental Cell Research  2009 315:2231-2240  DOI:10.1016/j.yexcr.2009.03.008  PMID:19306868  PMCID:PMC2696577
    • Furumatsu, T., Ozaki, T., Asahara, H. Smad3 activates the Sox9-dependent transcription on chromatin International Journal of Biochemistry & Cell Biology  2009 41:1198-1204  DOI:10.1016/j.biocel.2008.10.032  PMID:19041414  PMCID:PMC2674534
    • Suzuki, H., Forrest, A. R. R., van Nimwegen, E., Daub, C. O., Balwierz, P. J., Irvine, K. M., Lassmann, T., Ravasi, T., Hasegawa, Y., de Hoon, M. J. L., Katayama, S., Schroder, K., et al. The transcriptional network that controls growth arrest and differentiation in a human myeloid leukemia cell line Nature Genetics  2009 41:553-562  DOI:10.1038/ng.375  PMID:19377474
    • Yamasaki, K., Nakasa, T., Miyaki, S., Ishikawa, M., Deie, M., Adachi, N., Yasunaga, Y., Asahara, H., Ochi, M. Expression of microRNA-146a in osteoarthritis cartilage Arthritis and Rheumatism  2009 60:1035-1041  DOI:10.1002/art.24404  PMID:19333945  PMCID:PMC2670476
    • Hikata, T., Takaishi, H., Takito, J., Hakozaki, A., Furukawa, M., Uchikawa, S., Kimura, T., Okada, Y., Matsumoto, M., Yoshimura, A., Nishimura, R., Reddy, S. V., et al. PIAS3 negatively regulates RANKL-mediated osteoclastogenesis directly in osteoclast precursors and indirectly via osteoblasts Blood  2009 113:2202-2212  DOI:10.1182/blood-2008-06-162594  PMID:18952894  PMCID:PMC3401028
    • Shimizu, H., Uchibe, K., Asahara, H. Large-scale whole mount in situ hybridization of mouse embryos Methods in Molecular Biology  2009 577:167-79  DOI:10.1007/978-1-60761-232-2_13  PMID:19718516
    • Grogan, S. P., Miyaki, S., Asahara, H., D'Lima, D. D., Lotz, M. K. Mesenchymal progenitor cell markers in human articular cartilage: normal distribution and changes in osteoarthritis Arthritis Research & Therapy  2009 11:R85  DOI:10.1186/ar2719  PMID:19500336  PMCID:PMC2714136
    • Sakai, N., Terami, H., Suzuki, S., Haga, M., Nomoto, K., Tsuchida, N., Morohashi, K. I., Saito, N., Asada, M., Hashimoto, M., Harada, D., Asahara, H., et al. Identification of NR5A1 (SF-1/AD4BP) gene expression modulators by large-scale gain and loss of function studies Journal of Endocrinology  2008 198:489-497  DOI:10.1677/joe-08-0027  PMID:18579725
    • Nakasa, T., Miyaki, S., Okubo, A., Hashimoto, M., Nishida, K., Ochi, M., Asahara, H. Expression of microRNA-146 in rheumatoid arthritis synovial tissue Arthritis and Rheumatism  2008 58:1284-1292  DOI:10.1002/art.23429  PMID:18438844  PMCID:PMC2749927
    • Hashimoto, M., Nakasa, T., Hikata, T., Asahara, H. Molecular network of cartilage homeostasis and osteoarthritis Medicinal Research Reviews  2008 28:464-481  DOI:10.1002/med.20113  PMID:17880012
    • Yokoyama, S., Hashimoto, M., Shimizu, H., Ueno-Kudoh, H., Uchibe, K., Kimura, I., Asahara, H. Dynamic gene expression of Lin-28 during embryonic development in mouse and chicken Gene Expression Patterns  2008 8:155-160  DOI:10.1016/j.gep.2007.11.001  PMID:18077221  PMCID:PMC2262948
    • Manabe, H., Nasu, Y., Komiyama, T., Furumatsu, T., Kitamura, A., Miyazawa, S., Ninomiya, Y., Ozaki, T., Asahara, H., Nishida, K. Inhibition of histone deacetylase down-regulates the expression of hypoxia-induced vascular endothelial growth factor by rheumatoid synovial fibroblasts Inflammation Research  2008 57:4-10  DOI:10.1007/s00011-007-7036-z  PMID:18209959
    • Shimizu, H., Yokoyama, S., Asahara, H. Growth and differentiation of the developing limb bud from the perspective of chondrogenesis Development Growth & Differentiation  2007 49:449-454  DOI:10.1111/j.1440-169x.2007.00945.x  PMID:17661739
    • Taniguchi, N., Yoshida, K., Ito, T., Tsuda, M., Mishima, Y., Furumatsu, T., Ronfani, L., Abeyama, K., Kawahara, K., Komiya, S., Maruyama, I., Lotz, M., et al. Stage-specific secretion of HMGB1 in cartilage regulates endochondral ossification Molecular and Cellular Biology  2007 27:5650-5663  DOI:10.1128/mcb.00130-07  PMID:17548469
    • Sato, K., Suematsu, A., Nakashima, T., Takemoto-Kimura, S., Aoki, K., Morishita, Y., Asahara, H., Ohya, K., Yamaguchi, A., Takai, T., Kodama, T., Chatila, T. A., et al. Regulation of osteoclast differentiation and function by the CaMK-CREB pathway Nature Medicine  2006 12:1410-1416  DOI:10.1038/nm1515  PMID:17128269
    • Furumatsu, T., Tsuda, M., Yoshida, K., Taniguchi, N., Ito, T., Hashimoto, M., Asahara, H. Sox9 and p300 cooperatively regulate chromatin-mediated transcription Journal of Biological Chemistry  2005 280:35203-35208  DOI:10.1074/jbc.M502409200  PMID:16109717
    • Furumatsu, T., Tsuda, M., Taniguchi, N., Tajima, Y., Asahara, H. Smad3 induces chondrogenesis through the activation of SOX9 via CREB-binding protein/p300 recruitment Journal of Biological Chemistry  2005 280:8343-8350  DOI:10.1074/jbc.M413913200  PMID:15623506
    • Kawakami, Y., Tsuda, M., Takahashi, S., Taniguchi, N., Esteban, C. R., Zemmyo, M., Furumatsu, T., Lotz, M., Belmonte, J. C. I., Asahara, H. Transcriptional coactivator PGC-1 alpha regulates chondrogenesis via association with Sox9 Proceedings of the National Academy of Sciences of the United States of America  2005 102:2414-2419  DOI:10.1073/pnas.0407510102  PMID:15699338  PMCID:PMC548985
    • Omoto, S., Nishida, K., Yamaai, Y., Shibahara, M., Nishida, T., Doi, T., Asahara, H., Nakanishi, T., Inoue, H., Takigawa, M. Expression and localization of connective tissue growth factor (CTGF/Hcs24/CCN2) in osteoarthritic cartilage Osteoarthritis and Cartilage  2004 12:771-778  DOI:10.1016/j.joca.2004.06.009  PMID:15450526
    • Kato, T., Asahara, H., Kurokawa, M., Fujisawa, K., Hasunuma, T., Inoue, H., Tsuda, M., Takahashi, S., Motokawa, S., Sumida, T., Nishioka, K. HTLV-I env protein acts as a major antigen in patients with HTLV-I-associated arthropathy Clinical Rheumatology  2004 23:400-409  DOI:10.1007/s10067-004-0901-z  PMID:15459812
    • Nishida, K., Komiyama, T., Miyazawa, S., Shen, Z. N., Furumatsu, T., Doi, H., Yoshida, A., Yamana, J., Yamamura, M., Ninomiya, Y., Inoue, H., Asahara, H. Histone deacetylase inhibitor suppression of auto antibody-mediated arthritis in mice via regulation of p16(INK4a) and p21(WAF1/Cip1) expression Arthritis and Rheumatism  2004 50:3365-3376  DOI:10.1002/art.20709  PMID:15476220
    • Tsuda, M., Takahashi, S., Takahashi, Y., Asahara, H. Transcriptional co-activators CREB-binding protein and p300 regulate chondrocyte-specific gene expression via association with Sox9 Journal of Biological Chemistry  2003 278:27224-27229  DOI:10.1074/jbc.M303471200  PMID:12732631
    • Kawakami, Y., Rodriguez-Leon, J., Koth, C. M., Buscher, D., Itoh, T., Raya, A., Ng, J. K., Esteban, C. R., Takahashi, S., Henrique, D., Schwarz, M. F., Asahara, H., et al. MKP3 mediates the cellular response to FGF8 signalling in the vertebrate limb Nature Cell Biology  2003 5:513-519  DOI:10.1038/ncb989  PMID:12766772
    • Canettieri, G., Morantte, I., Guzman, E., Asahara, H., Herzig, S., Anderson, S. D., Yates, J. R., Montminy, M. Attenuation of a phosphorylation-dependent activator by an HDAC-PP1 complex Nature Structural Biology  2003 10:175-181  DOI:10.1038/nsb895  PMID:12567184
    • Asahara, H., Tartare-Deckert, S., Nakagawa, T., Ikehara, T., Hirose, F., Hunter, T., Ito, T., Montminy, M. Dual roles of p300 in chromatin assembly and transcriptional activation in cooperation with nucleosome assembly protein 1 in vitro Molecular and Cellular Biology  2002 22:2974-2983  DOI:10.1128/mcb.22.9.2974-2983.2002  PMID:11940655
    • Xu, W., Chen, H. W., Du, K. Y., Asahara, H., Tini, M., Emerson, B. M., Montminy, M., Evans, R. M. A transcriptional switch mediated by cofactor methylation Science  2001 294:2507-2511  DOI:10.1126/science.1065961  PMID:11701890
    • Asahara, H., Santoso, B., Guzman, E., Du, K. Y., Cole, P. A., Davidson, I., Montminy, M. Chromatin-dependent cooperativity between constitutive and inducible activation domains in CREB Molecular and Cellular Biology  2001 21:7892-7900  DOI:10.1128/mcb.21.23.7892-7900.2001  PMID:11689682
    • Long, F. X., Schipani, E., Asahara, H., Kronenberg, H., Montminy, M. The CREB family of activators is required for endochondral bone development Development  2001 128:541-550  PMID:11171337
    • Sekine, T., Masuko-Hongo, K., Matsui, T., Asahara, H., Takigawa, M., Nishioka, K., Kato, T. Recognition of YKL-39, a human cartilage related protein, as a target antigen in patients with rheumatoid arthritis Annals of the Rheumatic Diseases  2001 60:49-54  DOI:10.1136/ard.60.1.49  PMID:11114282
    • Du, K. Y., Asahara, H., Jhala, U. S., Wagner, B. L., Montminy, M. Characterization of a CREB gain-of-function mutant with constitutive transcriptional activity in vivo Molecular and Cellular Biology  2000 20:4320-4327  DOI:10.1128/mcb.20.12.4320-4327.2000  PMID:10825195
    • Asaumi, K., Nakanishi, T., Asahara, H., Inoue, H., Takigawa, M. Expression of neurotrophins and their receptors (TRK) during fracture healing Bone  2000 26:625-633  DOI:10.1016/s8756-3282(00)00281-7  PMID:10831935
    • Shibahara, M., Nishida, K., Asahara, H., Yoshikawa, T., Mitani, S., Kondo, Y., Inoue, H. Increased osteocyte apoptosis during the development of femoral head osteonecrosis in spontaneously hypertensive rats Acta Medica Okayama  2000 54:67-74  PMID:10806527
    • Michael, L. F., Asahara, H., Shulman, A. I., Kraus, W. L., Montminy, M. The phosphorylation status of a cyclic AMP-responsive activator is modulated via a chromatin-dependent mechanism Molecular and Cellular Biology  2000 20:1596-1603  DOI:10.1128/mcb.20.5.1596-1603.2000  PMID:10669737
    • Asahara, H., Dutta, S., Kao, H. Y., Evans, R. M., Montminy, M. Pbx-hox heterodimers recruit coactivator-corepressor complexes in an isoform-specific manner Molecular and Cellular Biology  1999 19:8219-8225  PMID:10567547  PMCID:PMC84906
    • Suzuki, M., Asahara, H., Endo, S., Inada, K., Doi, M., Kuroda, K., Ogawa, A. Increased levels of nitrite/nitrate in the cerebrospinal fluid of patients with subarachnoid hemorrhage Neurosurgical Review  1999 22:96-98  DOI:10.1007/s101430050038  PMID:10547005
    • Maeda, T., Keino, H., Asahara, H., Taniguchi, M., Nishioka, K., Sumida, T. Decreased TCR AV24AJ18(+) double-negative T cells in rheumatoid synovium Rheumatology  1999 38:186-188  DOI:10.1093/rheumatology/38.2.186  PMID:10342637
    • Okamoto, K., Asahara, H., Kobayashi, T., Matsuno, H., Hasunuma, T., Kobata, T., Sumida, T., Nishioka, K. Induction of apoptosis in the rheumatoid synovium by Fas ligand gene transfer Gene Therapy  1998 5:331-338  DOI:10.1038/sj.gt.3300597  PMID:9614552
    • Takagoshi, H., Hashizume, H., Nishida, K., Masaoka, S., Asahara, H., Inoue, H. Fibrous structure and connection surrounding the metacarpophalangeal joint Acta Medica Okayama  1998 52:19-26  PMID:9548990
    • Pu, J., Nishida, K., Inoue, H., Asahara, H., Ohtsuka, A., Murakami, T. Mast cells in osteoarthritic and rheumatoid arthritic synovial tissues of the human knee Acta Medica Okayama  1998 52:35-39  PMID:9548992
    • Sumida, T., Hasunuma, T., Asahara, H., Maeda, T., Nishioka, K. Rheumatoid arthritis and apoptosis Internal Medicine  1998 37:184-188  DOI:10.2169/internalmedicine.37.184  PMID:9550603
    • Fujisawa, K., Okamoto, K., Asahara, H., Hasunuma, T., Kobata, T., Kato, T., Sumida, T., Nishioka, K. Evidence for autoantigens of Env/Tax proteins in human T cell leukemia virus type I Env-pX transgenic mice Arthritis and Rheumatism  1998 41:101-109  PMID:9433875
    • Kobata, T., Takasaki, K., Asahara, H., Hong, N. M., MasukoHongo, K., Kato, T., Hirose, S., Shirai, T., Kayagaki, N., Yagita, H., Okumura, K., Nishioka, K. Apoptosis with FasL+ cell infiltration in the periphery and thymus of corrected autoimmune mice Immunology  1997 92:206-213  DOI:10.1046/j.1365-2567.1997.00347.x  PMID:9415028
    • Xue, C., Hasunuma, T., Asahara, H., Yin, W., Maeda, T., Fujisawa, K., Dong, Y., Sumida, T., Nishioka, K. Transcriptional regulation of the HOX4C gene by basic fibroblast growth factor on rheumatoid synovial fibroblasts Arthritis and Rheumatism  1997 40:1628-1635  DOI:10.1002/art.1780400912  PMID:9324017
    • Asahara, H., Fujisawa, K., Kobata, T., Hasunuma, T., Maeda, T., Asanuma, M., Ogawa, N., Inoue, H., Sumida, T., Nishioka, K. Direct evidence of high DNA binding activity of transcription factor AP-1 in rheumatoid arthritis synovium Arthritis and Rheumatism  1997 40:912-918  DOI:10.1002/art.1780400520  PMID:9153554
    • Suzuki, M., Ogawa, A., Asahara, H., Endo, S., Inada, K. Nitric oxide and vasospasm Journal of Neurosurgery  1997 86:741-741  PMID:9120649
    • Asahara, H., Hasunuma, T., Kobata, T., Inoue, H., MullerLadner, U., Gay, S., Sumida, T., Nishioka, K. In situ expression of protooncogenes and Fas/Fas ligand in rheumatoid arthritis synovium Journal of Rheumatology  1997 24:430-435  PMID:9058644
    • Sumida, T., Hoa, T. T. M., Asahara, H., Hasunuma, T., Nishioka, K. T cell receptor of Fas-sensitive T cells in rheumatoid synovium Journal of Immunology  1997 158:1965-1970  PMID:9029139
    • Hasunuma, T., Kayagaki, N., Asahara, H., Motokawa, S., Kobata, T., Yagita, H., Aono, H., Sumida, T., Okumura, K., Nishioka, K. Accumulation of soluble Fas in inflamed joints of patients with rheumatoid arthritis Arthritis and Rheumatism  1997 40:80-86  DOI:10.1002/art.1780400112  PMID:9008603
    • Asahara, H., Hasumuna, T., Kobata, T., Yagita, H., Okumura, K., Inoue, H., Gay, S., Sumida, T., Nishioka, K. Expression of fas antigen and Fas ligand in the rheumatoid synovial tissue Clinical Immunology and Immunopathology  1996 81:27-34  DOI:10.1006/clin.1996.0153  PMID:8808638
    • Hasunuma, T., Hoa, T. T. M., Aono, H., Asahara, H., Yonehara, S., Yamamoto, K., Sumida, T., Gay, S., Nishioka, K. Induction of Fas-dependent apoptosis in synovial infiltrating cells in rheumatoid arthritis International Immunology  1996 8:1595-1602  DOI:10.1093/intimm/8.10.1595  PMID:8921439
    • Fujisawa, K., Asahara, H., Okamoto, K., Aono, H., Hasunuma, T., Kobata, T., Iwakura, Y., Yonehara, S., Sumida, T., Nishioka, K. Therapeutic effect of the anti-Fas antibody on arthritis in HTLV-I fax transgenic mice Journal of Clinical Investigation  1996 98:271-278  DOI:10.1172/jci118789  PMID:8755634  PMCID:PMC507427
    • Hashizume, H., Asahara, H., Nishida, K., Inoue, H., Konishiike, T. Histopathology of Kienbock's disease - Correlation with magnetic resonance and other imaging techniques Journal of Hand Surgery-British and European Volume  1996 21B:89-93  DOI:10.1016/s0266-7681(96)80019-2  PMID:8676037
    • Asahara, H., Kawai, A., Harada, Y., Senda, M., Inoue, H. Spinal schwannomas: a review of 42 cases Acta Medica Okayama  1996 50:25-28  PMID:8701778
    • Asahara, H., Yokoi, I., Tamada, T., Kabuto, H., Ogawab, N., Mori, A., Inoue, H. Increased cerebrospinal fluid nitrite and nitrate levels in patients with lumbar spondylosis Research Communications in Molecular Pathology and Pharmacology  1996 91:77-83  PMID:8824933
    • Asahara, H., Asanuma, M., Ogawa, N., Nishibayashi, S., Inoue, H. High DNA-binding activity of transcription factor NF-kappa B in synovial membranes of patients with rheumatoid arthritis Biochemistry and Molecular Biology International  1995 37:827-832  PMID:8624487
    • Asahara, H., Kabuto, H., Yokoi, I., Habu, H., Mori, A., Inoue, H. Nitric oxide synthase inhibited by audouine in the rat brain Neuroreport  1995 6:1146-1148  DOI:10.1097/00001756-199505300-00018  PMID:7545018
    • Kabuto, H., Yokoi, I., Habu, H., Asahara, H., Mori, A. Inhibitory effect of arcaine on nitric oxide synthase in the rat brain Neuroreport  1995 6:554-556  DOI:10.1097/00001756-199502000-00036  PMID:7539305
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Affiliation

member of

  • National Institute of Biomedical Imaging and Bioengineering Ad Hoc Member, National Institute of Biomedical Imaging and Bioengineering 2015
  • National Institutes of Health Member, Skeletal Biology Structure & Regeneration (SBSR) Study Section 2011 - 2015
  • Arthritis Foundation Member, Arthritis Foundation Molecular Immunology Study Section 2004 - 2006
  • National Institutes of Health Ad Hoc Member, NIH Musculoskeletal, Oral, and Skin (MOSS) Study Section 2004
  • National Institutes of Health Ad Hoc Member, NIH Skeletal Biology Development and Disease (SBDD) Study Section 2004
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Research

research overview

  • As a molecular biologist and orthopedic surgeon, Dr. Asahara's research focuses on examining the precise mechanism of chromatin-dependent gene regulation related to limb development. Combining these new findings in molecular and developmental biology, with clinical research in the field of locomotive science, our aim is to develop innovative new therapies that will benefit patients with arthritis, bone tumor and spinal cord injuries.
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Background

education and training

  • Ph.D., Okayama University 1997
  • M.D. in Medicine, Okayama University , Medical School 1992

awards and honors

  • Hulda Irene Duggan Arthritis Investigator Award, Arthritis Foundation, conferred by Arthritis Foundation, 2002
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Contact

full name

  • Hiroshi Asahara

geographic location

  • Scripps California 
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Identity

eRA Commons ID

  • ASAHARA

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