Adibekian, Alexander

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- Hoch, D. G., Abegg, D., Hannich, J. T., Pechalrieu, D., Shuster, A., Dwyer, B. G., Wang, C., Zhang, X. J., You, Q. D., Riezman, H., Adibekian, A. Combined Omics Approach Identifies Gambogic Acid and Related Xanthones as Covalent Inhibitors of the Serine Palmitoyltransferase Complex Cell Chemical Biology 2020 27:586-597 DOI:10.1016/j.chembiol.2020.03.008 PMID:32330443
- Tessier, R., Nandi, R. K., Dwyer, B. G., Abegg, D., Sornay, C., Ceballos, J., Erb, S., Cianferani, S., Wagner, A., Chaubet, G., Adibekian, A., Waser, J. Ethynylation of Cysteine Residues: From Peptides to Proteins in Vitro and in Living Cells Angewandte Chemie-International Edition 2020 59:10961-10970 DOI:10.1002/anie.202002626 PMID:32233093
- Liu, X. H., Haniff, H. S., Childs-Disney, J. L., Shuster, A., Aikawa, H., Adibekian, A., Disney, M. D. Targeted Degradation of the Oncogenic MicroRNA 17-92 Cluster by Structure-Targeting Ligands Journal of the American Chemical Society 2020 142:6970-6982 DOI:10.1021/jacs.9b13159 PMID:32233464
- Costales, M. G., Hoch, D. G., Abegg, D., Childs-Disney, J. L., Velagapudi, S. P., Adibekian, A., Disney, M. D. A designed small molecule inhibitor of a non-coding RNA sensitizes HER2 negative cancers to herceptin Journal of the American Chemical Society 2019 141:2960-2974 DOI:10.1021/jacs.8b10558 PMID:30726072 PMCID:PMC6400281
- Wang, C., Abegg, D., Dwyer, B. G., Adibekian, A. Discovery and evaluation of new activity-based probes for serine hydrolases Chembiochem 2019 DOI:10.1002/cbic.201900126 PMID:30968522
- Hoch, D. G., Abegg, D., Adibekian, A. Cysteine-reactive probes and their use in chemical proteomics Chemical Communications 2018 54:4501-4512 DOI:10.1039/c8cc01485j PMID:29645055
- Davis, D. C., Hoch, D. G., Wu, L., Abegg, D., Martin, B. S., Zhang, Z. Y., Adibekian, A., Dai, M. Total synthesis, biological evaluation, and target identification of rare Abies sesquiterpenoids Journal of the American Chemical Society 2018 140:17465-17473 DOI:10.1021/jacs.8b07652 PMID:30461272
- Zong, L., Bartolami, E., Abegg, D., Adibekian, A., Sakai, N., Matile, S. Epidithiodiketopiperazines: strain-promoted thiol-mediated cellular uptake at the highest tension ACS Central Science 2017 3:449-453 DOI:10.1021/acscentsci.7b00080 PMID:28573207 PMCID:PMC5445525
- Abegg, D., Gasparini, G., Hoch, D. G., Shuster, A., Bartolami, E., Matile, S., Adibekian, A. Strained cyclic disulfides enable cellular uptake by reacting with the transferrin receptor Journal of the American Chemical Society 2017 139:231-238 DOI:10.1021/jacs.6b09643 PMID:28001050
- Dewhurst-Maridor, G., Abegg, D., David, F. P. A., Rougemont, J., Scott, C. C., Adibekian, A., Riezman, H. The SAGA complex, together with transcription factors and the endocytic protein Rvs167p, coordinates the reprofiling of gene expression in response to changes in sterol composition in Saccharomyces cerevisiae Molecular Biology of the Cell 2017 28:2637-2649 DOI:10.1091/mbc.E17-03-0169 PMID:28768829 PMCID:PMC5620372
- Wang, C., Abegg, D., Hoch, D. G., Adibekian, A. Chemoproteomics-enabled discovery of a potent and selective inhibitor of the DNA repair protein MGMT Angewandte Chemie-International Edition 2016 55:2911-2915 DOI:10.1002/anie.201511301 PMID:26798972
- Adibekian, A., Stallforth, P. Cutting edge chemical biology: Report from the 2016 International Symposium on Chemical Biology, January 13-15, Geneva, Switzerland ACS Chemical Biology 2016 11:816-820 DOI:10.1021/acschembio.6b00267 PMID:27079361
- Hoch, D. G., Abegg, D., Wang, C., Shuster, A., Adibekian, A. Cysteine-specific chemical proteomics: from target identification to drug discovery Chimia 2016 70:764-767 DOI:10.2533/chimia.2016.764 PMID:28661335
- Lagoutte, R., Serba, C., Abegg, D., Hoch, D. G., Adibekian, A., Winssinger, N. Divergent synthesis and identification of the cellular targets of deoxyelephantopins Nature Communications 2016 7 DOI:10.1038/ncomms12470 PMID:27539788 PMCID:PMC4992173
- Daguer, J. P., Zambaldo, C., Abegg, D., Barluenga, S., Tallant, C., Muller, S., Adibekian, A., Winssinger, N. Identification of covalent bromodomain binders through DNA display of small molecules Angewandte Chemie-International Edition 2015 54:6057-6061 DOI:10.1002/anie.201412276 PMID:25772490
- Abegg, D., Frei, R., Cerato, L., Hari, D. P., Wang, C., Waser, J., Adibekian, A. Proteome-wide profiling of targets of cysteine reactive small molecules by using ethynyl benziodoxolone reagents Angewandte Chemie-International Edition 2015 54:10852-10857 DOI:10.1002/anie.201505641 PMID:26211368
- Cavallari, M., Stallforth, P., Kalinichenko, A., Rathwell, D. C. K., Gronewold, T. M. A., Adibekian, A., Mori, L., Landmann, R., Seeberger, P. H., De Libero, G. A semisynthetic carbohydrate-lipid vaccine that protects against S-pneumoniae in mice Nature Chemical Biology 2014 10:950-956 DOI:10.1038/nchembio.1650 PMID:25282505
- Blaskovic, S., Adibekian, A., Blanc, M., van der Goot, G. F. Mechanistic effects of protein palmitoylation and the cellular consequences thereof Chemistry and Physics of Lipids 2014 180:44-52 DOI:10.1016/j.chemphyslip.2014.02.001 PMID:24534427
- Kemp, L. E., Rusch, M., Adibekian, A., Bullen, H. E., Graindorge, A., Freymond, C., Rottmann, M., Braun-Breton, C., Baumeister, S., Porfetye, A. T., Vetter, I. R., Hedberg, C., et al. Characterization of a serine hydrolase targeted by acyl-protein thioesterase inhibitors in Toxoplasma gondii Journal of Biological Chemistry 2013 288:27002-27018 DOI:10.1074/jbc.M113.460709 PMID:23913689 PMCID:PMC3779702
- Komatsu, T., Hanaoka, K., Adibekian, A., Yoshioka, K., Terai, T., Ueno, T., Kawaguchi, M., Cravatt, B. F., Nagano, T. Diced electrophoresis gel assay for screening enzymes with specified activities Journal of the American Chemical Society 2013 135:6002-6005 DOI:10.1021/ja401792d PMID:23581642
- Stallforth, P., Matthies, S., Adibekian, A., Gillingham, D. G., Hilvert, D., Seeberger, P. H. De novo chemoenzymatic synthesis of sialic acid Chemical Communications 2012 48:11987-11989 DOI:10.1039/c2cc37305j PMID:23128386
- Adibekian, A., Martin, B. R., Chang, J. W., Hsu, K. L., Tsuboi, K., Bachovchin, D. A., Speers, A. E., Brown, S. J., Spicer, T., Fernandez-Vega, V., Ferguson, J., Hodder, P. S., et al. Confirming target engagement for reversible inhibitors in vivo by kinetically tuned activity-based probes Journal of the American Chemical Society 2012 134:10345-10348 DOI:10.1021/ja303400u PMID:22690931 PMCID:PMC3392194
- Hsu, K. L., Tsuboi, K., Adibekian, A., Pugh, H., Masuda, K., Cravatt, B. F. DAGLβ inhibition perturbs a lipid network involved in macrophage inflammatory responses Nature Chemical Biology 2012 8:999-1007 DOI:10.1038/nchembio.1105 PMID:23103940 PMCID:PMC3513945
- Martin, B. R., Wang, C., Adibekian, A., Tully, S. E., Cravatt, B. F. Global profiling of dynamic protein palmitoylation Nature Methods 2012 9:84-89 DOI:10.1038/nmeth.1769 PMID:22056678 PMCID:PMC3248616
- Oberli, M. A., Hecht, M. L., Bindschadler, P., Adibekian, A., Adam, T., Seeberger, P. H. A possible oligosaccharide-conjugate vaccine candidate for Clostridium difficile is antigenic and immunogenic Chemistry & Biology 2011 18:580-588 DOI:10.1016/j.chembiol.2011.03.009 PMID:21609839
- Adibekian, A., Stallforth, P., Hecht, M. L., Werz, D. B., Gagneux, P., Seeberger, P. H. Comparative bioinformatics analysis of the mammalian and bacterial glycomes Chemical Science 2011 2:337-344 DOI:10.1039/c0sc00322k
- Adibekian, A., Martin, B. R., Wang, C., Hsu, K. L., Bachovchin, D. A., Niessen, S., Hoover, H., Cravatt, B. F. Click-generated triazole ureas as ultrapotent in vivo-active serine hydrolase inhibitors Nature Chemical Biology 2011 7:469-478 DOI:10.1038/nchembio.579 PMID:21572424 PMCID:PMC3118922
- Gillingham, D. G., Stallforth, P., Adibekian, A., Seeberger, P. H., Hilvert, D. Chemoenzymatic synthesis of differentially protected 3-deoxysugars Nature Chemistry 2010 2:102-105 DOI:10.1038/nchem.504 PMID:21124399
- Bindschadler, P., Adibekian, A., Grunstein, D., Seeberger, P. H. De novo synthesis of differentially protected L-iduronic acid glycosylating agents Carbohydrate Research 2010 345:948-955 DOI:10.1016/j.carres.2010.02.004 PMID:20193949
- Kikkeri, R., Liu, X., Adibekian, A., Tsai, Y. H., Seeberger, P. H. Facile synthesis of size dependent Ru(II)-carbohydrate dendrimers via click chemistry Chemical Communications 2010 46:2197-2199 DOI:10.1039/b925113h PMID:20234904
- Oberli, M. A., Tamborrini, M., Tsai, Y. H., Werz, D. B., Horlacher, T., Adibekian, A., Gauss, D., Moller, H. M., Pluschke, G., Seeberger, P. H. Molecular analysis of carbohydrate-antibody interactions: case study using a Bacillus anthracis tetrasaccharide. Journal of the American Chemical Society 2010 132:10239-10241 DOI:10.1021/ja104027w PMID:20614885
- Ohara, T., Adibekian, A., Esposito, D., Stallforth, P., Seeberger, P. H. Towards the synthesis of a Yersinia pestis cell wall polysaccharide: enantioselective synthesis of an L-glycero-D-manno-heptose building block Chemical Communications 2010 46:4106-4108 DOI:10.1039/c000784f PMID:20454710
- Long, J. Z., Jin, X., Adibekian, A., Li, W. W., Cravatt, B. F. Characterization of tunable piperidine and piperazine carbamates as inhibitors of endocannabinoid hydrolases Journal of Medicinal Chemistry 2010 53:1830-1842 DOI:10.1021/jm9016976 PMID:20099888 PMCID:PMC2828288
- Bachovchin, D. A., Ji, T. Y., Li, W. W., Simon, G. M., Blankman, J. L., Adibekian, A., Hoover, H., Niessen, S., Cravatt, B. F. Superfamily-wide portrait of serine hydrolase inhibition achieved by library-versus-library screening Proceedings of the National Academy of Sciences of the United States of America 2010 107:20941-20946 DOI:10.1073/pnas.1011663107 PMID:21084632 PMCID:PMC3000285
- Stallforth, P., Lepenies, B., Adibekian, A., Seeberger, P. H. Carbohydrates: a frontier in medicinal chemistry Journal of Medicinal Chemistry 2009 52:5561-5577 DOI:10.1021/jm900819p
- Kikkeri, R., Lepenies, B., Adibekian, A., Laurino, P., Seeberger, P. H. In vitro imaging and in vivo liver targeting with carbohydrate capped quantum dots Journal of the American Chemical Society 2009 131:2110-2112 DOI:10.1021/ja807711w PMID:19199612
- Hecht, M. L., Stallforth, P., Silva, D. V., Adibekian, A., Seeberger, P. H. Recent advances in carbohydrate-based vaccines Current Opinion in Chemical Biology 2009 13:354-359 DOI:10.1016/j.cbpa.2009.05.127 PMID:19560394
- Stallforth, P., Adibekian, A., Seeberger, P. H. De Novo synthesis of a D-galacturonic acid thioglycoside as key to the total synthesis of a glycosphingolipid from Sphingomonas yanoikuyae Organic Letters 2008 10:1573-1576 DOI:10.1021/ol800227b PMID:18363404
- Adibekian, A., Timmer, M. S. M., Stallforth, P., van Rijn, J., Werz, D. B., Seeberger, P. H. Stereocontrolled synthesis of fully functionalized D-glucosamine monosaccharides via a domino nitro-Michael/Henry reaction Chemical Communications 2008 3549-3551 DOI:10.1039/b805159c PMID:18654709
- Adibekian, A., Bindschadler, P., Timmer, M. S. M., Noti, C., Schutzenmeister, N., Seeberger, P. H. De novo synthesis of uronic acid building blocks for assembly of heparin oligosaccharides Chemistry-a European Journal 2007 13:4510-4522 DOI:10.1002/chem.200700141 PMID:17444537
- Werz, D. B., Ranzinger, R., Herget, S., Adibekian, A., von der Lieth, C. W., Seeberger, P. H. Exploring the structural diversity of mammalian carbohydrates ("glycospace") by statistical databank analysis ACS Chemical Biology 2007 2:685-691 DOI:10.1021/cb700178s PMID:18041818
- Werz, D. B., Adibekian, A., Seeberger, P. H. Synthesis of a spore surface pentasaccharide of Bacillus anthracis European Journal of Organic Chemistry 2007 1976-1982 DOI:10.1002/ejoc.200601082
- Jasper, C., Adibekian, A., Busch, T., Quitschalle, M., Wittenberg, R., Kirschning, A. Total synthesis of cyclic diterpene tonantzitlolone based on a highly stereoselective substrate-controlled aldol reaction and ring-closing metathesis Chemistry-a European Journal 2006 12:8719-8734 DOI:10.1002/chem.200600082 PMID:16955524
- Kloth, K., Brunjes, M., Kunst, E., Joge, T., Gallier, F., Adibekian, A., Kirschning, A. Practical TEMPO-mediated oxidation of alcohols using different polymer-bound co-oxidants Advanced Synthesis & Catalysis 2005 347:1423-1434 DOI:10.1002/adsc.200505005
- Timmer, M. S. M., Adibekian, A., Seeberger, P. H. Short de novo synthesis of fully functionalized uronic acid monosaccharides Angewandte Chemie-International Edition 2005 44:7605-7607 DOI:10.1002/anie.200502742 PMID:16267873
report
- Adibekian, A., Martin, B. R., Chang, J. W., Hsu, K. L., Tsuboi, K., Bachovchin, D. A., Speers, A. E., Brown, S. J., Spicer, T., Fernandez-Vega, V., Ferguson, J., Cravatt, B. F., et al. Characterization of a Selective, Reversible Inhibitor of Lysophospholipase 2 (LYPLA2) Probe Reports from the NIH Molecular Libraries Program. 2010 PMID:24624468
- Adibekian, A., Martin, B. R., Chang, J. W., Hsu, K. L., Tsuboi, K., Bachovchin, D. A., Speers, A. E., Brown, S. J., Spicer, T., Fernandez-Vega, V., Ferguson, J., Cravatt, B. F., et al. Characterization of a selective, reversible inhibitor of lysophospholipase 1 (LYPLA1) Probe Reports from the NIH Molecular Libraries Program. 2010 PMID:24624465
- Adibekian, A., Martin, B. R., Speers, A. E., Brown, S. J., Spicer, T., Fernandez-Vega, V., Ferguson, J., Cravatt, B. F., Hodder, P., Rosen, H. Optimization and characterization of a triazole urea dual inhibitor for lysophospholipase 1 (LYPLA1) and lysophospholipase 2 (LYPLA2) Probe Reports from the NIH Molecular Libraries Program. 2010 PMID:23658947
- Adibekian, A., Hsu, K. L., Speers, A. E., Brown, S. J., Spicer, T., Fernandez-Vega, V., Ferguson, J., Cravatt, B. F., Hodder, P., Rosen, H. Optimization and characterization of a triazole urea inhibitor for alpha/beta hydrolase domain-containing protein 11 (ABHD11): anti-probe for LYPLA1/LYPLA2 dual inhibitor ML211 Probe Reports from the NIH Molecular Libraries Program. 2010 PMID:23658953
- Adibekian, A., Hsu, K. L., Speers, A. E., Monillas, E. S., Brown, S. J., Spicer, T., Fernandez-Vega, V., Ferguson, J., Bahnson, B. J., Cravatt, B. F., Hodder, P., Rosen, H. Optimization and characterization of a triazole urea inhibitor for platelet-activating factor acetylhydrolase type 2 (PAFAH2) Probe Reports from the NIH Molecular Libraries Program. 2010 PMID:23658960

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