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Adibekian, Alexander
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Adibekian, Alexander

Faculty Member
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Positions

  • 2017 - Associate Professor, Chemistry , Scripps Research
  • 2013 - 2017 Assistant Professor, University of Geneva
  • 2012 - 2013 Independent Researcher, University of Geneva
  • 2009 - 2012 Postdoctoral Researcher, Scripps Research

Contact

  • aadibeki@scripps.edu

Websites

  • Alexander Adibekian, Ph.D.
  • Publications
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  • Background
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Publications

h-index

  • 25

recent publications
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  • Publications without PubMed PMIDs

  • academic article

    • Tessier, R., Nandi, R. K., Dwyer, B. G., Abegg, D., Sornay, C., Ceballos, J., Erb, S., Cianferani, S., Wagner, A., Chaubet, G., Adibekian, A., Waser, J. Ethynylation of Cysteine Residues: From Peptides to Proteins in Vitro and in Living Cells Angewandte Chemie-International Edition  2020 59:10961-10970  DOI:10.1002/anie.202002626  PMID:32233093
    • Hoch, D. G., Abegg, D., Hannich, J. T., Pechalrieu, D., Shuster, A., Dwyer, B. G., Wang, C., Zhang, X. J., You, Q. D., Riezman, H., Adibekian, A. Combined Omics Approach Identifies Gambogic Acid and Related Xanthones as Covalent Inhibitors of the Serine Palmitoyltransferase Complex Cell Chemical Biology  2020 27:586-597  DOI:10.1016/j.chembiol.2020.03.008  PMID:32330443
    • Liu, X. H., Haniff, H. S., Childs-Disney, J. L., Shuster, A., Aikawa, H., Adibekian, A., Disney, M. D. Targeted Degradation of the Oncogenic MicroRNA 17-92 Cluster by Structure-Targeting Ligands Journal of the American Chemical Society  2020 142:6970-6982  DOI:10.1021/jacs.9b13159  PMID:32233464
    • Sobolewski, C., Abegg, D., Berthou, F., Dolicka, D., Calo, N., Sempoux, C., Fournier, M., Maeder, C., Ay, A. S., Clavien, P. A., Humar, B., Dufour, J. F., et al. S100A11/ANXA2 belongs to a tumour suppressor/oncogene network deregulated early with steatosis and involved in inflammation and hepatocellular carcinoma development Gut  2020 69:1841-1854  DOI:10.1136/gutjnl-2019-319019  PMID:31919231
    • Wang, C., Abegg, D., Dwyer, B. G., Adibekian, A. Discovery and evaluation of new activity-based probes for serine hydrolases Chembiochem  2019  DOI:10.1002/cbic.201900126  PMID:30968522
    • Costales, M. G., Hoch, D. G., Abegg, D., Childs-Disney, J. L., Velagapudi, S. P., Adibekian, A., Disney, M. D. A designed small molecule inhibitor of a non-coding RNA sensitizes HER2 negative cancers to herceptin Journal of the American Chemical Society  2019 141:2960-2974  DOI:10.1021/jacs.8b10558  PMID:30726072  PMCID:PMC6400281
    • Davis, D. C., Hoch, D. G., Wu, L., Abegg, D., Martin, B. S., Zhang, Z. Y., Adibekian, A., Dai, M. Total synthesis, biological evaluation, and target identification of rare Abies sesquiterpenoids Journal of the American Chemical Society  2018 140:17465-17473  DOI:10.1021/jacs.8b07652  PMID:30461272
    • Hoch, D. G., Abegg, D., Adibekian, A. Cysteine-reactive probes and their use in chemical proteomics Chemical Communications  2018 54:4501-4512  DOI:10.1039/c8cc01485j  PMID:29645055
    • Dewhurst-Maridor, G., Abegg, D., David, F. P. A., Rougemont, J., Scott, C. C., Adibekian, A., Riezman, H. The SAGA complex, together with transcription factors and the endocytic protein Rvs167p, coordinates the reprofiling of gene expression in response to changes in sterol composition in Saccharomyces cerevisiae Molecular Biology of the Cell  2017 28:2637-2649  DOI:10.1091/mbc.E17-03-0169  PMID:28768829  PMCID:PMC5620372
    • Zong, L., Bartolami, E., Abegg, D., Adibekian, A., Sakai, N., Matile, S. Epidithiodiketopiperazines: strain-promoted thiol-mediated cellular uptake at the highest tension ACS Central Science  2017 3:449-453  DOI:10.1021/acscentsci.7b00080  PMID:28573207  PMCID:PMC5445525
    • Abegg, D., Gasparini, G., Hoch, D. G., Shuster, A., Bartolami, E., Matile, S., Adibekian, A. Strained cyclic disulfides enable cellular uptake by reacting with the transferrin receptor Journal of the American Chemical Society  2017 139:231-238  DOI:10.1021/jacs.6b09643  PMID:28001050
    • Lagoutte, R., Serba, C., Abegg, D., Hoch, D. G., Adibekian, A., Winssinger, N. Divergent synthesis and identification of the cellular targets of deoxyelephantopins Nature Communications  2016 7  DOI:10.1038/ncomms12470  PMID:27539788  PMCID:PMC4992173
    • Adibekian, A., Stallforth, P. Cutting edge chemical biology: Report from the 2016 International Symposium on Chemical Biology, January 13-15, Geneva, Switzerland ACS Chemical Biology  2016 11:816-820  DOI:10.1021/acschembio.6b00267  PMID:27079361
    • Wang, C., Abegg, D., Hoch, D. G., Adibekian, A. Chemoproteomics-enabled discovery of a potent and selective inhibitor of the DNA repair protein MGMT Angewandte Chemie-International Edition  2016 55:2911-2915  DOI:10.1002/anie.201511301  PMID:26798972
    • Hoch, D. G., Abegg, D., Wang, C., Shuster, A., Adibekian, A. Cysteine-specific chemical proteomics: from target identification to drug discovery Chimia  2016 70:764-767  DOI:10.2533/chimia.2016.764  PMID:28661335
    • Abegg, D., Frei, R., Cerato, L., Hari, D. P., Wang, C., Waser, J., Adibekian, A. Proteome-wide profiling of targets of cysteine reactive small molecules by using ethynyl benziodoxolone reagents Angewandte Chemie-International Edition  2015 54:10852-10857  DOI:10.1002/anie.201505641  PMID:26211368
    • Daguer, J. P., Zambaldo, C., Abegg, D., Barluenga, S., Tallant, C., Muller, S., Adibekian, A., Winssinger, N. Identification of covalent bromodomain binders through DNA display of small molecules Angewandte Chemie-International Edition  2015 54:6057-6061  DOI:10.1002/anie.201412276  PMID:25772490
    • Cavallari, M., Stallforth, P., Kalinichenko, A., Rathwell, D. C. K., Gronewold, T. M. A., Adibekian, A., Mori, L., Landmann, R., Seeberger, P. H., De Libero, G. A semisynthetic carbohydrate-lipid vaccine that protects against S-pneumoniae in mice Nature Chemical Biology  2014 10:950-956  DOI:10.1038/nchembio.1650  PMID:25282505
    • Blaskovic, S., Adibekian, A., Blanc, M., van der Goot, G. F. Mechanistic effects of protein palmitoylation and the cellular consequences thereof Chemistry and Physics of Lipids  2014 180:44-52  DOI:10.1016/j.chemphyslip.2014.02.001  PMID:24534427
    • Kemp, L. E., Rusch, M., Adibekian, A., Bullen, H. E., Graindorge, A., Freymond, C., Rottmann, M., Braun-Breton, C., Baumeister, S., Porfetye, A. T., Vetter, I. R., Hedberg, C., et al. Characterization of a serine hydrolase targeted by acyl-protein thioesterase inhibitors in Toxoplasma gondii Journal of Biological Chemistry  2013 288:27002-27018  DOI:10.1074/jbc.M113.460709  PMID:23913689  PMCID:PMC3779702
    • Komatsu, T., Hanaoka, K., Adibekian, A., Yoshioka, K., Terai, T., Ueno, T., Kawaguchi, M., Cravatt, B. F., Nagano, T. Diced electrophoresis gel assay for screening enzymes with specified activities Journal of the American Chemical Society  2013 135:6002-6005  DOI:10.1021/ja401792d  PMID:23581642
    • Hsu, K. L., Tsuboi, K., Adibekian, A., Pugh, H., Masuda, K., Cravatt, B. F. DAGLβ inhibition perturbs a lipid network involved in macrophage inflammatory responses Nature Chemical Biology  2012 8:999-1007  DOI:10.1038/nchembio.1105  PMID:23103940  PMCID:PMC3513945
    • Adibekian, A., Martin, B. R., Chang, J. W., Hsu, K. L., Tsuboi, K., Bachovchin, D. A., Speers, A. E., Brown, S. J., Spicer, T., Fernandez-Vega, V., Ferguson, J., Hodder, P. S., et al. Confirming target engagement for reversible inhibitors in vivo by kinetically tuned activity-based probes Journal of the American Chemical Society  2012 134:10345-10348  DOI:10.1021/ja303400u  PMID:22690931  PMCID:PMC3392194
    • Stallforth, P., Matthies, S., Adibekian, A., Gillingham, D. G., Hilvert, D., Seeberger, P. H. De novo chemoenzymatic synthesis of sialic acid Chemical Communications  2012 48:11987-11989  DOI:10.1039/c2cc37305j  PMID:23128386
    • Martin, B. R., Wang, C., Adibekian, A., Tully, S. E., Cravatt, B. F. Global profiling of dynamic protein palmitoylation Nature Methods  2012 9:84-89  DOI:10.1038/nmeth.1769  PMID:22056678  PMCID:PMC3248616
    • Adibekian, A., Martin, B. R., Wang, C., Hsu, K. L., Bachovchin, D. A., Niessen, S., Hoover, H., Cravatt, B. F. Click-generated triazole ureas as ultrapotent in vivo-active serine hydrolase inhibitors Nature Chemical Biology  2011 7:469-478  DOI:10.1038/nchembio.579  PMID:21572424  PMCID:PMC3118922
    • Oberli, M. A., Hecht, M. L., Bindschadler, P., Adibekian, A., Adam, T., Seeberger, P. H. A possible oligosaccharide-conjugate vaccine candidate for Clostridium difficile is antigenic and immunogenic Chemistry & Biology  2011 18:580-588  DOI:10.1016/j.chembiol.2011.03.009  PMID:21609839
    • Adibekian, A., Stallforth, P., Hecht, M. L., Werz, D. B., Gagneux, P., Seeberger, P. H. Comparative bioinformatics analysis of the mammalian and bacterial glycomes Chemical Science  2011 2:337-344  DOI:10.1039/c0sc00322k
    • Bachovchin, D. A., Ji, T. Y., Li, W. W., Simon, G. M., Blankman, J. L., Adibekian, A., Hoover, H., Niessen, S., Cravatt, B. F. Superfamily-wide portrait of serine hydrolase inhibition achieved by library-versus-library screening Proceedings of the National Academy of Sciences of the United States of America  2010 107:20941-20946  DOI:10.1073/pnas.1011663107  PMID:21084632  PMCID:PMC3000285
    • Oberli, M. A., Tamborrini, M., Tsai, Y. H., Werz, D. B., Horlacher, T., Adibekian, A., Gauss, D., Moller, H. M., Pluschke, G., Seeberger, P. H. Molecular analysis of carbohydrate-antibody interactions: case study using a Bacillus anthracis tetrasaccharide. Journal of the American Chemical Society  2010 132:10239-10241  DOI:10.1021/ja104027w  PMID:20614885
    • Bindschadler, P., Adibekian, A., Grunstein, D., Seeberger, P. H. De novo synthesis of differentially protected L-iduronic acid glycosylating agents Carbohydrate Research  2010 345:948-955  DOI:10.1016/j.carres.2010.02.004  PMID:20193949
    • Long, J. Z., Jin, X., Adibekian, A., Li, W. W., Cravatt, B. F. Characterization of tunable piperidine and piperazine carbamates as inhibitors of endocannabinoid hydrolases Journal of Medicinal Chemistry  2010 53:1830-1842  DOI:10.1021/jm9016976  PMID:20099888  PMCID:PMC2828288
    • Gillingham, D. G., Stallforth, P., Adibekian, A., Seeberger, P. H., Hilvert, D. Chemoenzymatic synthesis of differentially protected 3-deoxysugars Nature Chemistry  2010 2:102-105  DOI:10.1038/nchem.504  PMID:21124399
    • Kikkeri, R., Liu, X., Adibekian, A., Tsai, Y. H., Seeberger, P. H. Facile synthesis of size dependent Ru(II)-carbohydrate dendrimers via click chemistry Chemical Communications  2010 46:2197-2199  DOI:10.1039/b925113h  PMID:20234904
    • Ohara, T., Adibekian, A., Esposito, D., Stallforth, P., Seeberger, P. H. Towards the synthesis of a Yersinia pestis cell wall polysaccharide: enantioselective synthesis of an L-glycero-D-manno-heptose building block Chemical Communications  2010 46:4106-4108  DOI:10.1039/c000784f  PMID:20454710
    • Stallforth, P., Lepenies, B., Adibekian, A., Seeberger, P. H. Carbohydrates: a frontier in medicinal chemistry Journal of Medicinal Chemistry  2009 52:5561-5577  DOI:10.1021/jm900819p
    • Hecht, M. L., Stallforth, P., Silva, D. V., Adibekian, A., Seeberger, P. H. Recent advances in carbohydrate-based vaccines Current Opinion in Chemical Biology  2009 13:354-359  DOI:10.1016/j.cbpa.2009.05.127  PMID:19560394
    • Kikkeri, R., Lepenies, B., Adibekian, A., Laurino, P., Seeberger, P. H. In vitro imaging and in vivo liver targeting with carbohydrate capped quantum dots Journal of the American Chemical Society  2009 131:2110-2112  DOI:10.1021/ja807711w  PMID:19199612
    • Stallforth, P., Adibekian, A., Seeberger, P. H. De Novo synthesis of a D-galacturonic acid thioglycoside as key to the total synthesis of a glycosphingolipid from Sphingomonas yanoikuyae Organic Letters  2008 10:1573-1576  DOI:10.1021/ol800227b  PMID:18363404
    • Adibekian, A., Timmer, M. S. M., Stallforth, P., van Rijn, J., Werz, D. B., Seeberger, P. H. Stereocontrolled synthesis of fully functionalized D-glucosamine monosaccharides via a domino nitro-Michael/Henry reaction Chemical Communications  2008 3549-3551  DOI:10.1039/b805159c  PMID:18654709
    • Werz, D. B., Ranzinger, R., Herget, S., Adibekian, A., von der Lieth, C. W., Seeberger, P. H. Exploring the structural diversity of mammalian carbohydrates ("glycospace") by statistical databank analysis ACS Chemical Biology  2007 2:685-691  DOI:10.1021/cb700178s  PMID:18041818
    • Werz, D. B., Adibekian, A., Seeberger, P. H. Synthesis of a spore surface pentasaccharide of Bacillus anthracis European Journal of Organic Chemistry  2007 1976-1982  DOI:10.1002/ejoc.200601082
    • Adibekian, A., Bindschadler, P., Timmer, M. S. M., Noti, C., Schutzenmeister, N., Seeberger, P. H. De novo synthesis of uronic acid building blocks for assembly of heparin oligosaccharides Chemistry-a European Journal  2007 13:4510-4522  DOI:10.1002/chem.200700141  PMID:17444537
    • Jasper, C., Adibekian, A., Busch, T., Quitschalle, M., Wittenberg, R., Kirschning, A. Total synthesis of cyclic diterpene tonantzitlolone based on a highly stereoselective substrate-controlled aldol reaction and ring-closing metathesis Chemistry-a European Journal  2006 12:8719-8734  DOI:10.1002/chem.200600082  PMID:16955524
    • Kloth, K., Brunjes, M., Kunst, E., Joge, T., Gallier, F., Adibekian, A., Kirschning, A. Practical TEMPO-mediated oxidation of alcohols using different polymer-bound co-oxidants Advanced Synthesis & Catalysis  2005 347:1423-1434  DOI:10.1002/adsc.200505005
    • Timmer, M. S. M., Adibekian, A., Seeberger, P. H. Short de novo synthesis of fully functionalized uronic acid monosaccharides Angewandte Chemie-International Edition  2005 44:7605-7607  DOI:10.1002/anie.200502742  PMID:16267873
  • report

    • Adibekian, A., Martin, B. R., Chang, J. W., Hsu, K. L., Tsuboi, K., Bachovchin, D. A., Speers, A. E., Brown, S. J., Spicer, T., Fernandez-Vega, V., Ferguson, J., Cravatt, B. F., et al. Characterization of a Selective, Reversible Inhibitor of Lysophospholipase 2 (LYPLA2) Probe Reports from the NIH Molecular Libraries Program. 2010  PMID:24624468
    • Adibekian, A., Martin, B. R., Chang, J. W., Hsu, K. L., Tsuboi, K., Bachovchin, D. A., Speers, A. E., Brown, S. J., Spicer, T., Fernandez-Vega, V., Ferguson, J., Cravatt, B. F., et al. Characterization of a selective, reversible inhibitor of lysophospholipase 1 (LYPLA1) Probe Reports from the NIH Molecular Libraries Program. 2010  PMID:24624465
    • Adibekian, A., Martin, B. R., Speers, A. E., Brown, S. J., Spicer, T., Fernandez-Vega, V., Ferguson, J., Cravatt, B. F., Hodder, P., Rosen, H. Optimization and characterization of a triazole urea dual inhibitor for lysophospholipase 1 (LYPLA1) and lysophospholipase 2 (LYPLA2) Probe Reports from the NIH Molecular Libraries Program. 2010  PMID:23658947
    • Adibekian, A., Hsu, K. L., Speers, A. E., Brown, S. J., Spicer, T., Fernandez-Vega, V., Ferguson, J., Cravatt, B. F., Hodder, P., Rosen, H. Optimization and characterization of a triazole urea inhibitor for alpha/beta hydrolase domain-containing protein 11 (ABHD11): anti-probe for LYPLA1/LYPLA2 dual inhibitor ML211 Probe Reports from the NIH Molecular Libraries Program. 2010  PMID:23658953
    • Adibekian, A., Hsu, K. L., Speers, A. E., Monillas, E. S., Brown, S. J., Spicer, T., Fernandez-Vega, V., Ferguson, J., Bahnson, B. J., Cravatt, B. F., Hodder, P., Rosen, H. Optimization and characterization of a triazole urea inhibitor for platelet-activating factor acetylhydrolase type 2 (PAFAH2) Probe Reports from the NIH Molecular Libraries Program. 2010  PMID:23658960
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Teaching

advisees

  • graduate advising relationship

    • Dwyer, Brendan Gerald, Ph.D.  candidate, 2018 -
    • Shuster, Anton, Ph.D.  candidate, 2018 -
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Background

education and training

  • Ph.D. in Chemistry, Swiss Federal Institute of Technology Zurich (ETH) 2004 - 2008
  • M.S. in Chemistry, Leibniz University of Hanover 2002 - 2004
  • B.Sc., Leibniz University of Hanover , Chemistry 1999 - 2002
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Contact

full name

  • Alexander Adibekian

geographic location

  • Scripps Florida 
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Identity

ORCID iD

  • ORCID iD http://orcid.org/0000-0001-6453-0244

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