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Adam, Gregory
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Adam, Gregory

Principal Scientist
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Positions

  • 2016 - Principal Scientist, In Vitro Pharmacology, Merck & Co., Inc.
  • 2015 - Principal Scientist, Merck & Co., Inc.
  • 2012 - Associate Director, Assay Development, Merck & Co., Inc.
  • 2013 - 2015 Associate Principal Scientist, Merck & Co., Inc.
  • 2011 - 2012 Screening Team Member, Merck & Co., Inc.
  • 2009 - 2011 Biochemical Discovery Biology Team Lead, Merck & Co., Inc.
  • 2004 - 2009 Research Fellow/ Senior Research Chemist, Department of Target Validation, Merck & Co., Inc.
  • 2003 - 2004 Senior Research Chemist, Department of Molecular Profiling, Merck & Co., Inc.
Innovative chemical biologist responsible for the management of a team focused on the development of biochemical and cellular ultra-high throughput screening assays to screen a 3 million compound library for lead and tool identification at a Fortune 500 pharmaceutical company. Unique skillset includes:
• Introduced and integrated high throughput mass spectrometry screening to enable challenging targets and eliminate false positives. 
• Guide diverse project teams on the generation of hit finding strategies for multiple target classes.
• Expertise with affinity selection/ mass spectrometry-based screening approaches for ligand identification.
• Developed a non-directed approach to activity-based protein profiling for chemical proteomics. 
• Creativity, leadership and strong communication and problem-solving skills.

Research Areas research areas

  • Drug Discovery (UMLS)
  • HIV (UMLS)

Websites

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Publications

recent publications
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  • Publications without PubMed PMIDs

  • academic article

    • Burlein, C., Wang, C., Xu, M., Bhatt, T., Stahlhut, M., Ou, Y., Adam, G. C., Heath, J., Klein, D. J., Sanders, J., Narayan, K., Abeywickrema, P., et al. Discovery of a distinct chemical and mechanistic class of allosteric HIV-1 integrase inhibitors with antiretroviral activity ACS Chemical Biology  2017 12:2858-2865  DOI:10.1021/acschembio.7b00550  PMID:29024587
    • Maria, J. P. S., Park, Y., Yang, L., Murgolo, N., Altman, M. D., Zuck, P., Adam, G., Chamberlin, C., Saradjian, P., Dandliker, P., Boshoff, H. I. M., Barry, C. E., et al. Linking high-throughput screens to identify MoAs and novel inhibitors of Mycobacterium tuberculosis dihydrofolate reductase ACS Chemical Biology  2017 12:2448-2456  DOI:10.1021/acschembio.7b00468  PMID:28806050
    • Pertusi, D. A., O'Donnell, G., Homsher, M. F., Solly, K., Patel, A., Stahler, S. L., Riley, D., Finley, M. F., Finger, E. N., Adam, G. C., Meng, J. C., Bell, D. J., et al. Prospective Assessment of Virtual Screening Heuristics Derived Using a Novel Fusion Score SLAS Discovery  2017 22:995-1006  DOI:10.1177/2472555217706058  PMID:28426940
    • Painter, R. E., Adam, G. C., Arocho, M., DiNunzio, E., Donald, R. G. K., Dorso, K., Genilloud, O., Gill, C., Goetz, M., Hairston, N. N., Murgolo, N., Nare, B., et al. Elucidation of DnaE as the antibacterial target of the natural product, nargenicin Chemistry & Biology  2015 22:1362-1373  DOI:10.1016/j.chembiol.2015.08.015  PMID:26456734
    • Meng, J., Lai, M. T., Munshi, V., Grobler, J., McCauley, J., Zuck, P., Johnson, E. N., Uebele, V. N., Hermes, J. D., Adam, G. C. Screening of HIV-1 protease using a combination of an ultra-high-throughput fluorescent-based assay and RapidFire mass spectrometry Journal of Biomolecular Screening  2015 20:606-615  DOI:10.1177/1087057115570838  PMID:25681434
    • Adam, G. C., Meng, J., Rizzo, J. M., Amoss, A., Lusen, J. W., Patel, A., Riley, D., Hunt, R., Zuck, P., Johnson, E. N., Uebele, V. N., Hermes, J. D. Use of high-throughput mass spectrometry to reduce false positives in protease uHTS screens Journal of Biomolecular Screening  2015 20:212-222  DOI:10.1177/1087057114555832  PMID:25336354
    • Vachal, P., Miao, S., Pierce, J. M., Guiadeen, D., Colandrea, V. J., Wyvratt, M. J., Salowe, S. P., Sonatore, L. M., Milligan, J. A., Hajdu, R., Gollapudi, A., Keohane, C. A., et al. 1,3,8-Triazaspiro[4.5]decane-2,4-diones as efficacious pan-inhibitors of hypoxia-inducible factor prolyl hydroxylase 1-3 (HIF PHD1-3) for the treatment of anemia Journal of Medicinal Chemistry  2012 55:2945-2959  DOI:10.1021/jm201542d  PMID:22364528
    • Adam, G. C., Parish, C. A., Wisniewski, D., Meng, J. C., Liu, M., Calati, K., Stein, B. D., Athanasopoulos, J., Liberator, P., Roemer, T., Harris, G., Chapman, K. T. Application of affinity selection/mass spectrometry to determine the structural isomer of parnafungins responsible for binding polyadenosine polymerase Journal of the American Chemical Society  2008 130:16704-16710  DOI:10.1021/ja805531w  PMID:19049464
    • Adam, G. C., Meng, J., Athanasopoulos, J., Zhang, X., Chapman, K. T. Affinity-based ranking of ligands for DPP-4 from mixtures Bioorganic & Medicinal Chemistry Letters  2007 17:2404-2407  DOI:10.1016/j.bmcl.2007.02.040  PMID:17337342
    • degree-related publication Adam, G. C., Burbaum, J., Kozarich, J. W., Patricelli, M. P., Cravatt, B. F. Mapping enzyme active sites in complex proteomes Journal of the American Chemical Society  2004 126:1363-1368  DOI:10.1021/ja038441g  PMID:14759193
    • degree-related publication Adam, G. C., Vanderwal, C. D., Sorensen, E. J., Cravatt, B. F. (-)-FR182877 is a potent and selective inhibitor of carboxylesterase-1 Angewandte Chemie-International Edition  2003 42:5480-5484  DOI:10.1002/anie.200352576  PMID:14618582
    • degree-related publication Speers, A. E., Adam, G. C., Cravatt, B. F. Activity-based protein profiling in vivo using a copper(i)-catalyzed azide-alkyne 3+2 cycloaddition Journal of the American Chemical Society  2003 125:4686-4687  DOI:10.1021/ja034490h  PMID:12696868
    • degree-related publication Adam, G. C., Sorensen, E. J., Cravatt, B. F. Chemical strategies for functional proteomics Molecular & Cellular Proteomics  2002 1:781-790  DOI:10.1074/mcp.R200006-MCP200  PMID:12438561
    • degree-related publication Adam, G. C., Sorensen, E. J., Cravatt, B. F. Proteomic profiling of mechanistically distinct enzyme classes using a common chemotype Nature Biotechnology  2002 20:805-809  DOI:10.1038/nbt714  PMID:12091914
    • degree-related publication Adam, G. C., Sorensen, E. J., Cravatt, B. F. Trifunctional chemical probes for the consolidated detection and identification of enzyme activities from complex proteomes Molecular & Cellular Proteomics  2002 1:828-835  DOI:10.1074/mcp.T200007-MCP200  PMID:12438565
    • degree-related publication Adam, G. C., Cravatt, B. F., Sorensen, E. J. Profiling the specific reactivity of the proteome with non-directed activity-based probes Chemistry & Biology  2001 8:81-95  DOI:10.1016/s1074-5521(00)90060-7  PMID:11182321
    • Buynak, J. D., Doppalapudi, V. R., Rao, A. S., Nidamarthy, S. D., Adam, G. The synthesis and evaluation of 2-substituted-7-(alkylidene)cephalosporin sulfones as β-lactamase inhibitors Bioorganic & Medicinal Chemistry Letters  2000 10:847-851  DOI:10.1016/s0960-894x(00)00094-9  PMID:10853645
    • Buynak, J. D., Doppalapudi, V. R., Adam, G. The synthesis and evaluation of 3-substituted-7-(alkylidene)cephalosporin sulfones as β-lactamase inhibitors Bioorganic & Medicinal Chemistry Letters  2000 10:853-857  DOI:10.1016/s0960-894x(00)00098-6  PMID:10853646
    • Buynak, J. D., Rao, A. S., Doppalapudi, V. R., Adam, G., Petersen, P. J., Nidamarthy, S. D. The synthesis and evaluation of 6-alkylidene-2'β-substituted penam sulfones as β-lactamase inhibitors Bioorganic & Medicinal Chemistry Letters  1999 9:1997-2002  DOI:10.1016/s0960-894x(99)00325-x  PMID:10450969
    • Buynak, J. D., Rao, A. S., Adam, G., Nidamarthy, S. D., Zhang, H. Synthesis of the first 2',6 bridged penams Journal of the American Chemical Society  1998 120:6846-6847  DOI:10.1021/ja980195z
    • Buynak, J. D., Rao, A. S., Ford, G. P., Carver, C., Adam, G., Geng, B., Bachmann, B., Shobassy, S., Lackey, S. 7-alkylidenecephalosporin esters as inhibitors of human leukocyte elastase Journal of Medicinal Chemistry  1997 40:3423-3433  DOI:10.1021/jm970351x  PMID:9341917
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Teaching

teaching activities

  • Physical Chemistry Laboratory Spring 1998 Teaching Assistant 1998
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Background

education and training

  • Ph.D. in Chemical Biology, Scripps Research 1998 - 2003
  • B.A. in Biology, Southern Methodist University 1994 - 1998
  • B.S. in Chemistry, Southern Methodist University 1994 - 1998

advisee of

  • graduate advising relationship

    • Cravatt, Benjamin, Ph.D.  candidacy, 1998 - 2003
    • Sorensen, Erik J., Ph.D.  candidacy, 1998 - 2003
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Contact

full name

  • Gregory Charles Adam

geographic location

  • Scripps California 

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