recent publications
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academic article
- Burlein, C., Wang, C., Xu, M., Bhatt, T., Stahlhut, M., Ou, Y., Adam, G. C., Heath, J., Klein, D. J., Sanders, J., Narayan, K., Abeywickrema, P., et al. Discovery of a distinct chemical and mechanistic class of allosteric HIV-1 integrase inhibitors with antiretroviral activity ACS Chemical Biology 2017 12:2858-2865 DOI:10.1021/acschembio.7b00550 PMID:29024587
- Maria, J. P. S., Park, Y., Yang, L., Murgolo, N., Altman, M. D., Zuck, P., Adam, G., Chamberlin, C., Saradjian, P., Dandliker, P., Boshoff, H. I. M., Barry, C. E., et al. Linking high-throughput screens to identify MoAs and novel inhibitors of Mycobacterium tuberculosis dihydrofolate reductase ACS Chemical Biology 2017 12:2448-2456 DOI:10.1021/acschembio.7b00468 PMID:28806050
- Pertusi, D. A., O'Donnell, G., Homsher, M. F., Solly, K., Patel, A., Stahler, S. L., Riley, D., Finley, M. F., Finger, E. N., Adam, G. C., Meng, J. C., Bell, D. J., et al. Prospective Assessment of Virtual Screening Heuristics Derived Using a Novel Fusion Score SLAS Discovery 2017 22:995-1006 DOI:10.1177/2472555217706058 PMID:28426940
- Painter, R. E., Adam, G. C., Arocho, M., DiNunzio, E., Donald, R. G. K., Dorso, K., Genilloud, O., Gill, C., Goetz, M., Hairston, N. N., Murgolo, N., Nare, B., et al. Elucidation of DnaE as the antibacterial target of the natural product, nargenicin Chemistry & Biology 2015 22:1362-1373 DOI:10.1016/j.chembiol.2015.08.015 PMID:26456734
- Meng, J., Lai, M. T., Munshi, V., Grobler, J., McCauley, J., Zuck, P., Johnson, E. N., Uebele, V. N., Hermes, J. D., Adam, G. C. Screening of HIV-1 protease using a combination of an ultra-high-throughput fluorescent-based assay and RapidFire mass spectrometry Journal of Biomolecular Screening 2015 20:606-615 DOI:10.1177/1087057115570838 PMID:25681434
- Adam, G. C., Meng, J., Rizzo, J. M., Amoss, A., Lusen, J. W., Patel, A., Riley, D., Hunt, R., Zuck, P., Johnson, E. N., Uebele, V. N., Hermes, J. D. Use of high-throughput mass spectrometry to reduce false positives in protease uHTS screens Journal of Biomolecular Screening 2015 20:212-222 DOI:10.1177/1087057114555832 PMID:25336354
- Vachal, P., Miao, S., Pierce, J. M., Guiadeen, D., Colandrea, V. J., Wyvratt, M. J., Salowe, S. P., Sonatore, L. M., Milligan, J. A., Hajdu, R., Gollapudi, A., Keohane, C. A., et al. 1,3,8-Triazaspiro[4.5]decane-2,4-diones as efficacious pan-inhibitors of hypoxia-inducible factor prolyl hydroxylase 1-3 (HIF PHD1-3) for the treatment of anemia Journal of Medicinal Chemistry 2012 55:2945-2959 DOI:10.1021/jm201542d PMID:22364528
- Adam, G. C., Parish, C. A., Wisniewski, D., Meng, J. C., Liu, M., Calati, K., Stein, B. D., Athanasopoulos, J., Liberator, P., Roemer, T., Harris, G., Chapman, K. T. Application of affinity selection/mass spectrometry to determine the structural isomer of parnafungins responsible for binding polyadenosine polymerase Journal of the American Chemical Society 2008 130:16704-16710 DOI:10.1021/ja805531w PMID:19049464
- Adam, G. C., Meng, J., Athanasopoulos, J., Zhang, X., Chapman, K. T. Affinity-based ranking of ligands for DPP-4 from mixtures Bioorganic & Medicinal Chemistry Letters 2007 17:2404-2407 DOI:10.1016/j.bmcl.2007.02.040 PMID:17337342
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Adam, G. C., Burbaum, J., Kozarich, J. W., Patricelli, M. P., Cravatt, B. F.
Mapping enzyme active sites in complex proteomes
Journal of the American Chemical Society
2004
126:1363-1368
DOI:10.1021/ja038441g
PMID:14759193
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Adam, G. C., Vanderwal, C. D., Sorensen, E. J., Cravatt, B. F.
(-)-FR182877 is a potent and selective inhibitor of carboxylesterase-1
Angewandte Chemie-International Edition
2003
42:5480-5484
DOI:10.1002/anie.200352576
PMID:14618582
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Speers, A. E., Adam, G. C., Cravatt, B. F.
Activity-based protein profiling in vivo using a copper(i)-catalyzed azide-alkyne 3+2 cycloaddition
Journal of the American Chemical Society
2003
125:4686-4687
DOI:10.1021/ja034490h
PMID:12696868
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Adam, G. C., Sorensen, E. J., Cravatt, B. F.
Chemical strategies for functional proteomics
Molecular & Cellular Proteomics
2002
1:781-790
DOI:10.1074/mcp.R200006-MCP200
PMID:12438561
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Adam, G. C., Sorensen, E. J., Cravatt, B. F.
Proteomic profiling of mechanistically distinct enzyme classes using a common chemotype
Nature Biotechnology
2002
20:805-809
DOI:10.1038/nbt714
PMID:12091914
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Adam, G. C., Sorensen, E. J., Cravatt, B. F.
Trifunctional chemical probes for the consolidated detection and identification of enzyme activities from complex proteomes
Molecular & Cellular Proteomics
2002
1:828-835
DOI:10.1074/mcp.T200007-MCP200
PMID:12438565
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Adam, G. C., Cravatt, B. F., Sorensen, E. J.
Profiling the specific reactivity of the proteome with non-directed activity-based probes
Chemistry & Biology
2001
8:81-95
DOI:10.1016/s1074-5521(00)90060-7
PMID:11182321
- Buynak, J. D., Doppalapudi, V. R., Rao, A. S., Nidamarthy, S. D., Adam, G. The synthesis and evaluation of 2-substituted-7-(alkylidene)cephalosporin sulfones as β-lactamase inhibitors Bioorganic & Medicinal Chemistry Letters 2000 10:847-851 DOI:10.1016/s0960-894x(00)00094-9 PMID:10853645
- Buynak, J. D., Doppalapudi, V. R., Adam, G. The synthesis and evaluation of 3-substituted-7-(alkylidene)cephalosporin sulfones as β-lactamase inhibitors Bioorganic & Medicinal Chemistry Letters 2000 10:853-857 DOI:10.1016/s0960-894x(00)00098-6 PMID:10853646
- Buynak, J. D., Rao, A. S., Doppalapudi, V. R., Adam, G., Petersen, P. J., Nidamarthy, S. D. The synthesis and evaluation of 6-alkylidene-2'β-substituted penam sulfones as β-lactamase inhibitors Bioorganic & Medicinal Chemistry Letters 1999 9:1997-2002 DOI:10.1016/s0960-894x(99)00325-x PMID:10450969
- Buynak, J. D., Rao, A. S., Adam, G., Nidamarthy, S. D., Zhang, H. Synthesis of the first 2',6 bridged penams Journal of the American Chemical Society 1998 120:6846-6847 DOI:10.1021/ja980195z
- Buynak, J. D., Rao, A. S., Ford, G. P., Carver, C., Adam, G., Geng, B., Bachmann, B., Shobassy, S., Lackey, S. 7-alkylidenecephalosporin esters as inhibitors of human leukocyte elastase Journal of Medicinal Chemistry 1997 40:3423-3433 DOI:10.1021/jm970351x PMID:9341917