recent publications
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academic article
- Hodges, T. R., Abbott, J. R., Little, A. J., Sarkar, D., Salovich, J. M., Howes, J. E., Akan, D. T., Sai, J., Arnold, A. L., Browning, C., Burns, M. C., Sobolik, T., et al. Discovery and structure-based optimization of benzimidazole-derived activators of SOS1-mediated nucleotide exchange on RAS Journal of Medicinal Chemistry 2018 61:8875-8894 DOI:10.1021/acs.jmedchem.8b01108 PMID:30205005
- Abbott, J. R., Patel, P. A., Howes, J. E., Akan, D. T., Kennedy, J. P., Burns, M. C., Browning, C. F., Sun, Q., Rossanese, O. W., Phan, J., Waterson, A. G., Fesik, S. W. Discovery of quinazolines that activate SOS1-mediated nucleotide exchange on RAS ACS Medicinal Chemistry Letters 2018 9:941-946 DOI:10.1021/acsmedchemlett.8b00296 PMID:30258545 PMCID:PMC6142059
- Abbott, J. R., Hodges, T. R., Daniels, R. N., Patel, P. A., Kennedy, J. P., Howes, J. E., Akan, D. T., Burns, M. C., Sai, J. Q., Sobolik, T., Beesetty, Y., Lee, T., et al. Discovery of aminopiperidine indoles that activate the guanine nucleotide exchange factor SOS1 and modulate RAS signaling Journal of Medicinal Chemistry 2018 61:6002-6017 DOI:10.1021/acs.jmedchem.8b00360 PMID:29856609
- Burns, M. C., Howes, J. E., Sun, Q., Little, A. J., Camper, D. V., Abbott, J. R., Phan, J., Lee, T., Waterson, A. G., Rossanese, O. W., Fesik, S. W. High-throughput screening identifies small molecules that bind to the RAS:SOS:RAS complex and perturb RAS signaling Analytical Biochemistry 2018 548:44-52 DOI:10.1016/j.ab.2018.01.025 PMID:29444450 PMCID:PMC5935105
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Abbott, J. R., Allais, C., Roush, W. R.
Preparattion of crystalline (diisopinocampheyl)borane
Organic Syntheses
2015
92:26-37
DOI:10.15227/orgsyn.092.0026
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Abbott, J. R., Allais, C., Roush, W. R.
Enantioselective reductive syn-aldol reactions of 4-acryloylmorpholine: preparation of (2R, 3S)-3-hydroxy-2-methyl-1-morpholino-5-phenylpentan-1-one
Organic Syntheses
2015
92:38-57
DOI:10.15227/orgsyn.092.0038
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Abbott, J. R., Roush, W. R.
Stereoselective synthesis of the disaccharide unit of incednine
Organic Letters
2013
15:62-64
DOI:10.1021/ol303093z
PMID:23249392
PMCID:PMC3537911
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Sun, H. K., Abbott, J. R., Roush, W. R.
Stereoselective synthesis of a model C(18)-C(35) spiroketal fragment of integramycin
Organic Letters
2011
13:2734-2737
DOI:10.1021/ol200834p
PMID:21510632
PMCID:PMC3094501
- Selvam, C., Thomas, S., Abbott, J., Kennedy, S. D., Rozners, E. Amides as excellent mimics of phosphate linkages in RNA Angewandte Chemie - International Edition 2011 50:2068-2070 DOI:10.1002/anie.201007012 PMID:21344553 PMCID:PMC3516995