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Abbott, Jason
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Abbott, Jason

Graduate Student
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Positions

  • 2018 - Senior Scientist I, AbbVie Pharmaceuticals
  • 2014 - 2018 Postdoctoral Research Fellow, Medicinal Chemistry, Vanderbilt University
  • 2007 Research Associate, Ancora Pharmaceuticals

Contact

  • jason.r.abbott@vanderbilt.edu

Websites

  • Doctoral Dissertation
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Publications

recent publications
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  • academic article

    • Hodges, T. R., Abbott, J. R., Little, A. J., Sarkar, D., Salovich, J. M., Howes, J. E., Akan, D. T., Sai, J., Arnold, A. L., Browning, C., Burns, M. C., Sobolik, T., et al. Discovery and structure-based optimization of benzimidazole-derived activators of SOS1-mediated nucleotide exchange on RAS Journal of Medicinal Chemistry  2018 61:8875-8894  DOI:10.1021/acs.jmedchem.8b01108  PMID:30205005
    • Abbott, J. R., Patel, P. A., Howes, J. E., Akan, D. T., Kennedy, J. P., Burns, M. C., Browning, C. F., Sun, Q., Rossanese, O. W., Phan, J., Waterson, A. G., Fesik, S. W. Discovery of quinazolines that activate SOS1-mediated nucleotide exchange on RAS ACS Medicinal Chemistry Letters  2018 9:941-946  DOI:10.1021/acsmedchemlett.8b00296  PMID:30258545  PMCID:PMC6142059
    • Abbott, J. R., Hodges, T. R., Daniels, R. N., Patel, P. A., Kennedy, J. P., Howes, J. E., Akan, D. T., Burns, M. C., Sai, J. Q., Sobolik, T., Beesetty, Y., Lee, T., et al. Discovery of aminopiperidine indoles that activate the guanine nucleotide exchange factor SOS1 and modulate RAS signaling Journal of Medicinal Chemistry  2018 61:6002-6017  DOI:10.1021/acs.jmedchem.8b00360  PMID:29856609
    • Burns, M. C., Howes, J. E., Sun, Q., Little, A. J., Camper, D. V., Abbott, J. R., Phan, J., Lee, T., Waterson, A. G., Rossanese, O. W., Fesik, S. W. High-throughput screening identifies small molecules that bind to the RAS:SOS:RAS complex and perturb RAS signaling Analytical Biochemistry  2018 548:44-52  DOI:10.1016/j.ab.2018.01.025  PMID:29444450  PMCID:PMC5935105
    • degree-related publication Abbott, J. R., Allais, C., Roush, W. R. Preparattion of crystalline (diisopinocampheyl)borane Organic Syntheses  2015 92:26-37  DOI:10.15227/orgsyn.092.0026
    • degree-related publication Abbott, J. R., Allais, C., Roush, W. R. Enantioselective reductive syn-aldol reactions of 4-acryloylmorpholine: preparation of (2R, 3S)-3-hydroxy-2-methyl-1-morpholino-5-phenylpentan-1-one Organic Syntheses  2015 92:38-57  DOI:10.15227/orgsyn.092.0038
    • degree-related publication Abbott, J. R., Roush, W. R. Stereoselective synthesis of the disaccharide unit of incednine Organic Letters  2013 15:62-64  DOI:10.1021/ol303093z  PMID:23249392  PMCID:PMC3537911
    • degree-related publication Sun, H. K., Abbott, J. R., Roush, W. R. Stereoselective synthesis of a model C(18)-C(35) spiroketal fragment of integramycin Organic Letters  2011 13:2734-2737  DOI:10.1021/ol200834p  PMID:21510632  PMCID:PMC3094501
    • Selvam, C., Thomas, S., Abbott, J., Kennedy, S. D., Rozners, E. Amides as excellent mimics of phosphate linkages in RNA Angewandte Chemie - International Edition  2011 50:2068-2070  DOI:10.1002/anie.201007012  PMID:21344553  PMCID:PMC3516995
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Background

education and training

  • Ph.D. in Chemistry, Scripps Research 2008 - 2014
  • B.S. in Chemistry, Northeastern University 2004 - 2008

awards and honors

  • Graduate Research Fellowship, conferred by Eli Lilly & Company, 2012
  • Outstanding Undergraduate Research Award, conferred by Northeastern University, 2008
  • Merck Summer Undergraduate Fellowship, conferred by Merck & Co., Inc., 2006
  • Dean's Scholarship, conferred by Northeastern University, 2004

advisee of

  • graduate advising relationship

    • Roush, William, Ph.D.  candidacy, 2009 - 2014
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Contact

full name

  • Jason R. Abbott

geographic location

  • Scripps Florida 

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