'Reverse' alpha-ketoamide-based p38 map kinase inhibitors Academic Article uri icon

publication date

  • 2008

abstract

  • We have identified a second series of potent p38 inhibitors. As with our first generation series, these compounds are based on an alpha-ketoamide scaffold. The reversal of the ketoamide order, however, introduces more chemical flexibility and in addition results in improve potencies against p38.