academic article

• Zorrilla, E. P., Heilig, M., de Wit, H., Shaham, Y.  Behavioral, biological, and chemical perspectives on targeting crf1 receptor antagonists to treat alcoholism  Drug and Alcohol Dependence  2013 128:175-186  DOI:10.1016/j.drugalcdep.2012.12.017  PMID:23294766
• Vendruscolo, L. F., Barbier, E., Schlosburg, J. E., Misra, K. K., Whitfield, T. W., Logrip, M. L., Rivier, C., Repunte-Canonigo, V., Zorrilla, E. P., Sanna, P. P., Heilig, M., Koob, G. F.  Corticosteroid-dependent plasticity mediates compulsive alcohol drinking in rats  Journal of Neuroscience  2012 32:7563-7571  DOI:10.1523/jneurosci.0069-12.2012
• Ha, Y. J., Saul, A., Tawfik, A., Zorrilla, E. P., Ganapathy, V., Smith, S. B.  Diabetes accelerates retinal ganglion cell dysfunction in mice lacking sigma receptor 1  Molecular Vision  2012 18:2860-2870  PMID:23233788
• Parylak, S. L., Cottone, P., Sabino, V., Rice, K. C., Zorrilla, E. P.  Effects of cb1 and crf1 receptor antagonists on binge-like eating in rats with limited access to a sweet fat diet: Lack of withdrawal-like responses  Physiology and Behavior  2012 107:231-242  DOI:10.1016/j.physbeh.2012.06.017
• Zorrilla, E. P., Wee, S., Zhao, Y., Specio, S., Boutrel, B., Koob, G. F., Weiss, F.  Extended access cocaine self-administration differentially activates dorsal raphe and amygdala corticotropin-releasing factor systems in rats  Addiction Biology  2012 17:300-308  DOI:10.1111/j.1369-1600.2011.00329.x  PMID:21762287
• Zakhari, J. S., Zorrilla, E. P., Zhou, B., Mayorov, A. V., Janda, K. D.  Oligoclonal antibody targeting ghrelin increases energy expenditure and reduces food intake in fasted mice  Molecular Pharmaceutics  2012 9:281-289  DOI:10.1021/mp200376c
• Logrip, M. L., Zorrilla, E. P.  Stress history increases alcohol intake in relapse: Relation to phosphodiesterase 10a  Addiction Biology  2012 17:920-933  DOI:10.1111/j.1369-1600.2012.00460.x
• Logrip, M. L., Zorrilla, E. P., Koob, G. F.  Stress modulation of drug self-administration: Implications for addiction comorbidity with post-traumatic stress disorder  Neuropharmacology  2012 62:552-564  DOI:10.1016/j.neuropharm.2011.07.007  PMID:21782834
• Sabino, V., Cottone, P., Blasio, A., Iyer, M. R., Steardo, L., Rice, K. C., Conti, B., Koob, G. F., Zorrilla, E. P.  Activation of sigma-receptors induces binge-like drinking in sardinian alcohol-preferring rats  Neuropsychopharmacology  2011 36:1207-1218  DOI:10.1038/npp.2011.5
• Ha, Y. J., Saul, A., Tawfik, A., Williams, C., Bollinger, K., Smith, R., Tachikawa, M., Zorrilla, E., Ganapathy, V., Smith, S. B.  Late-onset inner retinal dysfunction in mice lacking sigma receptor 1 (sigma r1)  Investigative Ophthalmology & Visual Science  2011 52:7749-7760  DOI:10.1167/iovs.11-8169
• Logrip, M. L., Koob, G. F., Zorrilla, E. P.  Role of corticotropin-releasing factor in drug addiction potential for pharmacological intervention  CNS Drugs  2011 25:271-287
• Walker, B. M., Zorrilla, E. P., Koob, G. F.  Systemic kappa-opioid receptor antagonism by nor-binaltorphimine reduces dependence-induced excessive alcohol self-administration in rats  Addiction Biology  2011 16:116-119  DOI:10.1111/j.1369-1600.2010.00226.x  PMID:20579007
• Fekete, E. M., Zhao, Y., Szucs, A., Sabino, V., Cottone, P., Rivier, J., Vale, W. W., Koob, G. F., Zorrilla, E. P.  Systemic urocortin 2, but not urocortin 1 or stressin1-a, suppresses feeding via crf2 receptors without malaise and stress  British Journal of Pharmacology  2011 164:1959-1975  DOI:10.1111/j.1476-5381.2011.01512.x
• Parylak, S. L., Koob, G. F., Zorrilla, E. P.  The dark side of food addiction  Physiology & Behavior  2011 104:149-156  DOI:10.1016/j.physbeh.2011.04.063
• Roberto, M., Cruz, M. T., Gilpin, N. W., Sabin, V., Schweitzer, P., Bajo, M., Cottone, P., Madamba, S. G., Stouffer, D. G., Zorrilla, E. P., Koob, G. F., Siggins, G. R., et al.  Corticotropin releasing factor-induced amygdala gamma-aminobutyric acid release plays a key role in alcohol dependence  Biological Psychiatry  2010 67:831-839  DOI:10.1016/j.biopsych.2009.11.007
• Repunte-Canonigo, V., van der Stap, L. D., Chen, J. H., Sabino, V., Wagner, U., Zorrilla, E. P., Schumann, G., Roberts, A. J., Sanna, P. P.  Genome-wide gene expression analysis identifies k-ras as a regulator of alcohol intake  Brain Research  2010 1339:1-10  DOI:10.1016/j.brainres.2010.03.063
• Koob, G. F., Zorrilla, E. P.  Neurobiological mechanisms of addiction: Focus on corticotropin-releasing factor  Current Opinion in Investigational Drugs  2010 11:63-71
• Power, M. L., Williams, L. E., Gibson, S. V., Schulkin, J., Helfers, J., Zorrilla, E. P.  Pattern of maternal circulating crh in laboratory-housed squirrel and owl monkeys  American Journal of Primatology  2010 72:1004-1012  DOI:10.1002/ajp.20850
• Zorrilla, E. P., Koob, G. F.  Progress in corticotropin-releasing factor-1 antagonist development  Drug Discovery Today  2010 15:371-383  DOI:10.1016/j.drudis.2010.02.011
• Martin-Fardon, R., Zorrilla, E. P., Ciccocioppo, R., Weiss, F.  Role of innate and drug-induced dysregulation of brain stress and arousal systems in addiction: Focus on corticotropin-releasing factor, nociceptin/orphanin fq, and orexin/hypocretin  Brain Research  2010 1314:145-161  DOI:10.1016/j.brainres.2009.12.027
• Cottone, P., Sabino, V., Steardo, L., Zorrilla, E. P.  Consummatory, anxiety-related and metabolic adaptations in female rats with alternating access to preferred food  Psychoneuroendocrinology  2009 34:38-49  DOI:10.1016/j.psyneuen.2008.08.010
• Greenwell, T. N., Funk, C. K., Cottone, P., Richardson, H. N., Chen, S. A., Rice, K. C., Zorrilla, E. P., Koob, G. F.  Corticotropin-releasing factor-1 receptor antagonists decrease heroin self-administration in long- but not short-access rats  Addiction Biology  2009 14:130-143  DOI:10.1111/j.1369-1600.2008.00142.x  PMID:19291009
• Cottone, P., Sabino, V., Roberto, M., Bajo, M., Pockros, L., Frihauf, J. B., Fekete, E. M., Steardo, L., Rice, K. C., Grigoriadis, D. E., Conti, B., Koob, G. F., et al.  Crf system recruitment mediates dark side of compulsive eating  Proceedings of the National Academy of Sciences of the United States of America  2009 106:20016-20020  DOI:10.1073/pnas.0908789106
• Fonareva, I., Spangler, E., Cannella, N., Sabino, V., Cottone, P., Ciccocioppo, R., Zorrilla, E. P., Ryabinin, A. E.  Increased perioculomotor urocortin 1 immunoreactivity in genetically selected alcohol preferring rats  Alcoholism-Clinical and Experimental Research  2009 33:1956-1965  DOI:10.1111/j.1530-0277.2009.01033.x
• Nie, Z. G., Zorrilla, E. P., Madamba, S. G., Rice, K. C., Roberto, M., Siggins, G. R.  Presynaptic crf(1) receptors mediate the ethanol enhancement of gabaergic transmission in the mouse central amygdala  Thescientificworldjournal  2009 9:68-85  DOI:10.1100/tsw.2009.1
• Francesconi, W., Berton, F., Repunte-Canonigo, V., Hagihara, K., Thurbon, D., Lekic, D., Specio, S. E., Greenwell, T. N., Chen, S. A., Rice, K. C., Richardson, H. N., O'Dell, L. E., et al.  Protracted withdrawal from alcohol and drugs of abuse impairs long-term potentiation of intrinsic excitability in the juxtacapsular bed nucleus of the stria terminalis  Journal of Neuroscience  2009 29:5389-5401  DOI:10.1523/jneurosci.5129-08.2009
• Sabino, V., Cottone, P., Zhao, Y., Steardo, L., Koob, G. F., Zorrilla, E. P.  Selective reduction of alcohol drinking in sardinian alcohol-preferring rats by a sigma-1 receptor antagonist  Psychopharmacology  2009 205:327-335  DOI:10.1007/s00213-009-1548-x
• Sabino, V., Cottone, P., Parylak, S. L., Steardo, L., Zorrilla, E. P.  Sigma-1 receptor knockout mice display a depressive-like phenotype  Behavioural Brain Research  2009 198:472-476  DOI:10.1016/j.bbr.2008.11.036
• Fekete, E. M., Zhao, Y., Li, C., Sabino, V., Vale, W. W., Zorrilla, E. P.  Social defeat stress activates medial amygdala cells that express type 2 corticotropin-releasing factor receptor mrna  Neuroscience  2009 162:5-13  DOI:10.1016/j.neuroscience.2009.03.078
• Greenwell, T. N., Walker, B. M., Cottone, P., Zorrilla, E. P., Koob, G. F.  The alpha(1) adrenergic receptor antagonist prazosin reduces heroin self-administration in rats with extended access to heroin administration  Pharmacology Biochemistry and Behavior  2009 91:295-302  DOI:10.1016/j.pbb.2008.07.012
• Sabino, V., Cottone, P., Zhao, Y., Iyer, M. R., Steardo, L., Rice, K. C., Conti, B., Rice, K. C., Koob, G. F., Zorrilla, E. P.  The sigma-receptor antagonist bd-1063 decreases ethanol intake and reinforcement in animal models of excessive drinking  Neuropsychopharmacology  2009 34:1482-1493  DOI:10.1038/npp.2008.192
• Szabadfi, K., Atlasz, T., Reglodi, D., Kiss, P., Danyadi, B., Fekete, E. M., Zorrilla, E. P., Tamas, A., Szabo, K., Gabriel, R.  Urocortin 2 protects against retinal degeneration following bilateral common carotid artery occlusion in the rat  Neuroscience Letters  2009 455:42-45  DOI:10.1016/j.neulet.2009.03.013
• Mayorov, A. V., Amara, N., Chang, J. Y., Moss, J. A., Hixon, M. S., Ruiz, D. I., Meijler, M. M., Zorrilla, E. P., Janda, K. D.  Catalytic antibody degradation of ghrelin increases whole-body metabolic rate and reduces refeeding in fasting mice  Proceedings of the National Academy of Sciences of the United States of America  2008 105:17487-17492  DOI:10.1073/pnas.0711808105
• Specio, S. E., Wee, S., O'Dell, L. E., Boutrel, B., Zorrilla, E. P., Koob, G. F.  Crf1 receptor antagonists attenuate escalated cocaine self-administration in rats  Psychopharmacology  2008 196:473-482  DOI:10.1007/s00213-007-0983-9
• Osborn, O., Gramm, H., Zorrilla, E. P., Conti, B., Bartfai, T.  Insights into the roles of the inflammatory mediators il-1, il-18 and pge2 in obesity and insulin resistance  Swiss Medical Weekly  2008 138:665-673
• Cottone, P., Sabino, V., Steardo, L., Zorrilla, E. P.  Intermittent access to preferred food reduces the reinforcing efficacy of chow in rats  American Journal of Physiology-Regulatory Integrative and Comparative Physiology  2008 295:R1066-R1076  DOI:10.1152/ajpregu.90309.2008
• Richardson, H. N., Zhao, Y., Fekete, E. M., Funk, C. K., Wirsching, P., Janda, K. D., Zorrilla, E. P., Koob, G. F.  Mpzp: A novel small molecule corticotropin-releasing factor type 1 receptor (crf1) antagonist  Pharmacology Biochemistry and Behavior  2008 88:497-510  DOI:10.1016/j.pbb.2007.10.008
• Cottone, P., Sabino, V., Steardo, L., Zorrilla, E. P.  Opioid-dependent anticipatory negative contrast and binge-like eating in rats with limited access to highly preferred food  Neuropsychopharmacology  2008 33:524-535  DOI:10.1038/sj.npp.1301430
• Lu, X. Y., Ross, B., Sanchez-Alavez, M., Zorrilla, E. P., Bartfai, T.  Phenotypic analysis of galr2 knockout mice in anxiety- and depression-related behavioral tests  Neuropeptides  2008 42:387-397  DOI:10.1016/j.npep.2008.04.009
• Sabino, V., Cottone, P., Steardo, L., Schmidhammer, H., Zorrilla, E. P.  14-methoxymetopon, a highly potent mu opioid agonist, biphasically affects ethanol intake in sardinian alcohol-preferring rats  Psychopharmacology  2007 192:537-546  DOI:10.1007/s00213-007-0746-7
• Funk, C. K., Zorrilla, E. P., Lee, M. J., Rice, K. C., Koob, G. F.  Corticotropin-releasing factor 1 antagonists selectively reduce ethanol self-administration in ethanol-dependent rats  Biological Psychiatry  2007 61:78-86  DOI:10.1016/j.biopsych.2006.03.063
• George, O., Ghozland, S., Azar, M. R., Cottone, P., Zorrilla, E. P., Parsons, L. H., O'Dell, L. E., Richardson, H. N., Koob, G. F.  Crf-crf1 system activation mediates withdrawal-induced increases in nicotine self-administration in nicotine-dependent rats  Proceedings of the National Academy of Sciences of the United States of America  2007 104:17198-17203  DOI:10.1073/pnas.0707585104
• Fekete, E. M., Inoue, K., Zhao, Y., Rivier, J. E., Vale, W. W., Szucs, A., Koob, G. F., Zorrilla, E. P.  Delayed satiety-like actions and altered feeding microstructure by a selective type 2 corticotropin-releasing factor agonist in rats: Intra-hypothalamic urocortin 3 administration reduces food intake by prolonging the post-meal interval  Neuropsychopharmacology  2007 32:1052-1068  DOI:10.1038/sj.npp.1301214
• Chu, K., Koob, G. F., Cole, M., Zorrilla, E. P., Roberts, A. J.  Dependence-induced increases in ethanol self-administration in mice are blocked by the crf, receptor antagonist antalarmin and by crf, receptor knockout  Pharmacology Biochemistry and Behavior  2007 86:813-821  DOI:10.1016/j.pbb.2007.03.009
• O'Dell, L. E., Chen, S. A., Smith, R. T., Specio, S. E., Balster, R. L., Paterson, N. E., Markou, A., Zorrilla, E. P., Koob, G. F.  Extended access to nicotine self-administration leads to dependence: Circadian measures, withdrawal measures, and extinction behavior in rats  Journal of Pharmacology and Experimental Therapeutics  2007 320:180-193  DOI:10.1124/jpet.106.105270
• Cottone, P., Sabino, V., Nagy, T. R., Coscina, D. V., Zorrilla, E. P.  Feeding microstructure in diet-induced obesity susceptible versus resistant rats: Central effects of urocortin 2  Journal of Physiology-London  2007 583:487-504  DOI:10.1113/jphysiol.2007.138867
• Cottone, P., Sabino, V., Steardo, L., Zorrilla, E. P.  Fg 7142 specifically reduces meal size and the rate and regularity of sustained feeding in female rats: Evidence that benzodiazepine inverse agonists reduce food palatability  Neuropsychopharmacology  2007 32:1069-1081  DOI:10.1038/sj.npp.1301229
• Zorrilla, E. P., Brennan, M., Sabino, V., Lu, X., Bartfal, T.  Galanin type 1 receptor knockout mice show altered responses to high-fat diet and glucose challenge  Physiology & Behavior  2007 91:479-485  DOI:10.1016/j.physbeh.2006.11.011
• Fekete, E. M., Zorrilla, E. P.  Physiology, pharmacology, and therapeutic relevance of urocortins in mammals: Ancient crf paralogs  Frontiers in Neuroendocrinology  2007 28:1-27  DOI:10.1016/j.yfrne.2006.09.002
• Zhao, Y., Weiss, F., Zorrilla, E. P.  Remission and resurgence of anxiety-like behavior across protracted withdrawal stages in ethanol-dependent rats  Alcoholism-Clinical and Experimental Research  2007 31:1505-1515  DOI:10.1111/j.1530-0277.2007.00456.x
• Tabarin, A., Diz-Chaves, Y., Consoli, D., Monsaingeon, M., Bale, T. L., Culler, M. D., Datta, R., Drago, F., Vale, W. W., Koob, G. F., Zorrilla, E. P., Contarino, A.  Role of the corticotropin-releasing factor receptor type 2 in the control of food intake in mice: A meal pattern analysis  European Journal of Neuroscience  2007 26:2303-2314  DOI:10.1111/j.1460-9568.2007.05856.x
• Zhao, Y., Valdez, G. R., Fekete, E. M., Rivier, J. E., Vale, W. W., Rice, K. C., Weiss, F., Zorrilla, E. P.  Subtype-selective corticotropin-releasing factor receptor agonists exert contrasting, but not opposite, effects on anxiety-related behavior in rats  Journal of Pharmacology and Experimental Therapeutics  2007 323:846-854  DOI:10.1124/jpet.107.123208
• Sabino, V., Cottone, P., Koob, G. F., Steardo, L., Lee, M. J., Rice, K. C., Zorrilla, E. P.  Dissociation between opioid and crf1 antagonist sensitive drinking in sardinian alcohol-preferring rats  Psychopharmacology  2006 189:175-186  DOI:10.1007/s00213-006-0546-5
• Richardson, H. N., Zorrilla, E. P., Mandyam, C. D., Rivier, C. L.  Exposure to repetitive versus varied stress during prenatal development generates two distinct anxiogenic and neuroendocrine profiles in adulthood  Endocrinology  2006 147:2506-2517  DOI:10.1210/en.2005-1054
• Conti, B., Sanchez-Alavez, M., Winsky-Sommerer, R., Morale, M. C., Lucero, J., Brownell, S., Fabre, V., Huitron-Resendiz, S., Henriksen, S., Zorrilla, E. P., de Lecea, L., Bartfai, T.  Transgenic mice with a reduced core body temperature have an increased life span  Science  2006 314:825-828  DOI:10.1126/science.1132191
• Chen, S. A., O'Dell, L. E., Hoefer, M. E., Greenwell, T. N., Zorrilla, E. P., Koob, G. F.  Unlimited access to heroin self-administration: Independent motivational markers of opiate dependence  Neuropsychopharmacology  2006 31:2692-2707  DOI:10.1038/sj.npp.1301008
• Chen, A., Zorrilla, E., Smith, S., Rousso, D., Levy, C., Vaughan, J., Donaldson, C., Roberts, A., Lee, K. F., Vale, W.  Urocortin 2-deficient mice exhibit gender-specific alterations in circadian hypothalamus-pituitary-adrenal axis and depressive-like behavior  Journal of Neuroscience  2006 26:5500-5510  DOI:10.1523/jneurosci.3955-05.2006
• Zorrilla, E. P., Iwasaki, S., Moss, J. A., Chang, J., Otsuji, J., Inoue, K., Meijler, M. M., Janda, K. D.  Vaccination against weight gain  Proceedings of the National Academy of Sciences of the United States of America  2006 103:13226-13231  DOI:10.1073/pnas.0605376103
• Stinus, L., Cador, M., Zorrilla, E. P., Koob, G. F.  Buprenorphine and a crf1 antagonist block the acquisition of opiate withdrawal-induced conditioned place aversion in rats  Neuropsychopharmacology  2005 30:90-98  DOI:10.1038/sj.npp.1300487
• Valdez, G. R., Zorrilla, E. P., Koob, G. F.  Homeostasis within the corticotropin-releasing factor system via crf2 receptor activation: A novel approach for the treatment of anxiety  Drug Development Research  2005 65:205-215  DOI:10.1002/ddr.20024
• Zorrilla, E. P., Inoue, K., Valdez, G. R., Tabarin, A., Koob, G. F.  Leptin and post-prandial satiety: Acute central leptin more potently reduces meal frequency than meal size in the rat  Psychopharmacology  2005 177:324-335  DOI:10.1007/s00213-004-1952-1
• Zorrilla, E. P., Inoue, K., Fekete, E. M., Tabarin, A., Valdez, G. R., Koob, G. F.  Measuring meals: Structure of prandial food and water intake of rats  American Journal of Physiology-Regulatory Integrative and Comparative Physiology  2005 288:R1450-R1467  DOI:10.1152/ajpregu.00175.2004
• Tabarin, A., Chaves, Y. D., Carmona, M. D., Catargi, B., Zorrilla, E. P., Roberts, A. J., Coscina, D. V., Rousset, S., Redonnet, A., Parker, G. C., Inoue, K., Ricquier, D., et al.  Resistance to diet-induced obesity in mu-opioid receptor-deficient mice: Evidence for a "thrifty gene"  Diabetes  2005 54:3510-3516  DOI:10.2337/diabetes.54.12.3510
• Zorrilla, E. P., Reinhardt, L. E., Valdez, G. R., Inoue, K., Rivier, J. E., Vale, W. W., Koob, G. F.  Human urocortin 2, a corticotropin-releasing factor (crf)(2) agonist, and ovine crf, a crf1 agonist, differentially alter feeding and motor activity  Journal of Pharmacology and Experimental Therapeutics  2004 310:1027-1034  DOI:10.1124/jpet.104.068676
• Inoue, K., Zorrilla, E. P., Tabarin, A., Valdez, G. R., Iwasaki, S., Kiriike, N., Koob, G. F.  Reduction of anxiety after restricted feeding in the rat: Implication for eating disorders  Biological Psychiatry  2004 55:1075-1081  DOI:10.1016/j.biopsych.2004.01.026
• Zorrilla, E. P., Koob, G. F.  The therapeutic potential of crf1 antagonists for anxiety  Expert Opinion on Investigational Drugs  2004 13:799-828  DOI:10.1517/13543784.13.7.799
• Valdez, G. R., Zorrilla, E. P., Roberts, A. J., Koob, G. F.  Antagonism of corticotropin-releasing factor attenuates the enhanced responsiveness to stress observed during protracted ethanol abstinence  Alcohol  2003 29:55-60  DOI:10.1016/s0741-8329(03)00020-x
• Inoue, K., Valdez, G. R., Reyes, T. M., Reinhardt, L. E., Tabarin, A., Rivier, J., Vale, W. W., Sawchenko, P. E., Koob, G. F., Zorrilla, E. P.  Human urocortin ii, a selective agonist for the type 2 corticotropin-releasing factor receptor, decreases feeding and drinking in the rat  Journal of Pharmacology and Experimental Therapeutics  2003 305:385-393  DOI:10.1124/jpet.102.047712
• Valdez, G. R., Zorrilla, E. P., Rivier, J., Vale, W. W., Koob, G. F.  Locornotor suppressive and anxiolytic-like effects of urocortin 3, a highly selective type 2 corticotropin-releasing factor agonist  Brain Research  2003 980:206-212  DOI:10.1016/s0006-8993(03)02971-8
• Zorrilla, E. P., Tache, Y., Koob, G. F.  Nibbling at crf receptor control of feeding and gastrocolonic motility  Trends in Pharmacological Sciences  2003 24:421-427  DOI:10.1016/s0165-6147(03)00177-9
• Zorrilla, E. P., Valdez, G. R., Nozulak, J., Koob, G. F., Markou, A.  Effects of antalarmin, a crf type 1 receptor antagonist, on anxiety-like behavior and motor activation in the rat  Brain Research  2002 952:188-199  DOI:10.1016/s0006-8993(02)03189-x
• Valdez, G. R., Inoue, K., Koob, G. F., Rivier, J., Vale, W., Zorrilla, E. P.  Human urocortin ii: Mild locomotor suppressive and delayed anxiolytic-like effects of a novel corticotropin-releasing factor related peptide  Brain Research  2002 943:142-150  DOI:10.1016/s0006-8993(02)02707-5
• Valdez, G. R., Roberts, A. J., Chan, K., Davis, H., Brennan, M., Zorrilla, E. P., Koob, G. F.  Increased ethanol self-administration and anxiety-like behavior during acute ethanol withdrawal and protracted abstinence: Regulation by corticotropin-releasing factor  Alcoholism-Clinical and Experimental Research  2002 26:1494-1501  DOI:10.1097/01.alc.0000033120.51856.f0
• Spina, M. G., Merlo-Pich, E., Akwa, Y., Balducci, C., Basso, A. M., Zorrilla, E. P., Britton, K. T., Rivier, J., Vale, W. W., Koob, G. F.  Time-dependent induction of anxiogenic-like effects after central infusion of urocortin or corticotropin-releasing factor in the rat  Psychopharmacology  2002 160:113-121  DOI:10.1007/s00213-001-0940-y
• Zorrilla, E. P., Schulteis, G., Ormsby, A., Klaassen, A., Ling, N., McCarthy, J. R., Koob, G. F., De Souza, E. B.  Urocortin shares the memory modulating effects of corticotropin-releasing factor (crf): Mediation by crf1 receptors  Brain Research  2002 952:200-210  DOI:10.1016/s0006-8993(02)03345-0
• Zorrilla, E. P., Valdez, G. R., Weiss, F.  Changes in levels of regional crf-like-immunoreactivity and plasma corticosterone during protracted drug withdrawal in dependent rats  Psychopharmacology  2001 158:374-381  DOI:10.1007/s002130100773
• Zorrilla, E. P., Schulteis, G., Ling, N., Koob, G. F., De Souza, E. B.  Performance-enhancing effects of crf-bp ligand inhibitors  Neuroreport  2001 12:1231-1234  DOI:10.1097/00001756-200105080-00035
• Zorrilla, E. P., Luborsky, L., McKay, J. R., Rosenthal, R., Houldin, A., Tax, A., McCorkle, R., Seligman, D. A., Schmidt, K.  The relationship of depression and stressors to immunological assays: A meta-analytic review  Brain Behavior and Immunity  2001 15:199-226  DOI:10.1006/brbi.2000.0597
• Richter, R. M., Zorrilla, E. P., Basso, A. M., Koob, G. F., Weiss, F.  Altered amygdalar crf release and increased anxiety-like behavior in sardinian alcohol-preferring rats: A microdialysis and behavioral study  Alcoholism-Clinical and Experimental Research  2000 24:1765-1772  DOI:10.1111/j.1530-0277.2000.tb01979.x
• Spina, M. G., Basso, A. M., Zorrilla, E. P., Heyser, C. J., Rivier, J., Vale, W., Merlo-Pich, E., Koob, G. F.  Behavioral effects of central administration of the novel crf antagonist astressin in rats  Neuropsychopharmacology  2000 22:230-239  DOI:10.1016/s0893-133x(99)00108-6
• Zorrilla, E. P., Cannon, T. D., Kessler, J., Gur, R. E.  Leukocyte differentials predict short-term clinical outcome following antipsychotic treatment in schizophrenia  Biological Psychiatry  1998 43:887-896  DOI:10.1016/s0006-3223(97)00358-2
• Zorrilla, E. P.  Multiparous species present problems (and possibilities) to developmentalists  Developmental Psychobiology  1997 30:141-150  DOI:10.1002/(sici)1098-2302(199703)30:2<141::aid-dev5>3.0.co;2-q
• Halasz, I., Rittenhouse, P. A., Zorrilla, E. P., Redei, E.  Sexually dimorphic effects of maternal adrenalectomy on hypothalamic corticotrophin-releasing factor, glucocorticoid receptor and anterior pituitary pomc mrna levels in rat neonates  Developmental Brain Research  1997 100:198-204  DOI:10.1016/s0165-3806(97)00033-3
• Zorrilla, E. P., Cannon, T. D., Gur, R. E., Kessler, J.  Leukocytes and organ-nonspecific autoantibodies in schizophrenics and their siblings: Markers of vulnerability or disease?  Biological Psychiatry  1996 40:825-833  DOI:10.1016/0006-3223(95)00598-6
• Zorrilla, E. P., McKay, J. R., Luborsky, L., Schmidt, K.  Relation of stressors and depressive symptoms to clinical progression of viral illness  American Journal of Psychiatry  1996 153:626-635
• Zorrilla, E. P., Derubeis, R. J., Redei, E.  High self-esteem, hardiness and affective stability are associated with higher basal pituitary-adrenal hormone levels  Psychoneuroendocrinology  1995 20:591-601  DOI:10.1016/0306-4530(95)00005-9
• Zorrilla, E. P., Redei, E., Derubeis, R. J.  Reduced cytokine levels and t-cell function in healthy-males - relation to individual-differences in subclinical anxiety  Brain Behavior and Immunity  1994 8:293-312  DOI:10.1006/brbi.1994.1028
• Guillen, M. A., Delavega, M. S., Zorrilla, E., Hernandez, A.  Treatment of diabetic polyneuropathy with tolrestat, an aldose reductase inhibitor  Current Therapeutic Research-Clinical and Experimental  1994 55:455-467  DOI:10.1016/s0011-393x(05)80532-6
• Calderon, E., Cruz, A., Rangel, H., Coronel, A., Zorrilla, E.  Treatment of acute diarrhea in adults  Current Therapeutic Research-Clinical and Experimental  1991 49:792-800
• Calderon, E., Gatica, R., Echaniz, G., Conde, C., Salinas, L., Olvera, G., Zorrilla, E., Velazquez, M. E.  Treatment of presumed bacterial pneumonia in ambulatory children  Clinical Therapeutics  1991 13:699-706
• Bialostozky, D., Luengo, M., Magos, C., Zorrilla, E.  Coronary insufficiency in children - coronary arteriographic studies in 2 siblings from a family with hyperbetalipoproteinemia  American Journal of Cardiology  1975 36:509-514  DOI:10.1016/0002-9149(75)90903-0
• Zorrilla, E., Del Pilar Valencia, M., Serrano, P. A.  Evaluation of a screening test for hyperlipidemia  JAMA-Journal of the American Medical Association  1974 228:589-590  DOI:10.1001/jama.228.5.589  PMID:4406187
• Arcila, H., Chavez de los Rios, J., Van Dyck, R., Zorrilla, E.  Hypercalcaemia, hypophosphataemia, and inability to excrete hydrogen ions  British Medical Journal  1972 4:400-403  PMID:4637153
• Hernandez, A., Zorrilla, E., Gershberg, H.  Decreased insulin production, elevated growth hormone levels, and glucose intolerance in liver disease  Journal of Laboratory and Clinical Medicine  1969 73:25-33  PMID:5762161
• Gershberg, H., Zorrilla, E., Hernandez, A., Hulse, M.  Effects of medroxyprogesterone acetate on serum insulin and growth hormone levels in diabetics and potential diabetics  Obstetrics and Gynecology  1969 33:383-389  PMID:5776088
• Zorrilla, E., Hulse, M., Hernandez, A., Gershberg, H.  Severe endogenous hypertriglyceridemia during treatment with estrogen and oral contraceptives  Journal of Clinical Endocrinology & Metabolism  1968 28:1793-1796  PMID:4177383
• Zorrilla, E., Kozak, G. P.  Ophthalmoplegia in diabetes mellitus  Annals of Internal Medicine  1967 67:968-976
• Ewing, C., Zorrilla, E., Hernandez, A., Berris, R.  Diabetic vascular complications in long-standing panhypopituitarism with diabetes. A case report  Diabetes  1966 15:419-422  PMID:5327900