head of
- Weiss Laboratory Professor
Weiss, Friedbert Faculty Member
Positions
- Professor, Weiss Laboratory, Molecular and Cellular Neuroscience 1989 -
- Associate Director, Pearson Center for Alcohol and Addiction Research, The Scripps Research Institute 2004 -
- Faculty Member, Neurosciences Graduate Program, University of California, San Diego 1997 -
- Professor, Molecular and Cellular Neuroscience, The Scripps Research Institute 2013 -
- Professor, Molecular and Integrative Neurosciences (MIND), The Scripps Research Institute 2000 - 2012
- Associate Professor with Tenure, Neuropharmacology 1999 - 2005
- Associate Adjunct Professor, Department of Psychiatry, University of California, San Diego 1996 - 2002
- Associate Professor, Neuropharmacology 1997 - 1999
- Associate Member, Neuropharmacology 1994 - 1997
- Assistant Member, Neuropharmacology 1989 - 1993
- Visiting Scientist, Department of Pharmacology, Karolinska Institute 1988 - 1989
- Postdoctoral Fellow, Preclinical Neuroscience and Endocrinology, Research Institute of Scripps Clinic 1986 - 1989
Dr. Friedbert Weiss investigates the neurobiology of addictive disorders, focusing on understanding the brain neurocircuitry as well as the neurochemical and molecular mechanisms that mediate the addictive effects of drugs of abuse, contribute to the development of dependence, and convey vulnerability to relapse.
Affiliation
Publications
selected publications
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academic article
- Martin-Fardon, R., Weiss, F. Modeling relapse in animals Curr Top Behav Neurosci 2013 13:403-32 DOI:10.1007/7854_2012_202 PMID:22389178
- Martin-Fardon, R., Weiss, F. (-)-2-oxa-4-aminobicylco 3.1.0 hexane-4,6-dicarboxylic acid (ly379268) and 3- (2-methyl-1,3-thiazol-4-yl)ethynyl piperidine (mtep) similarly attenuate stress-induced reinstatement of cocaine seeking Addiction Biology 2012 17:557-564 DOI:10.1111/j.1369-1600.2011.00345.x
- Martin-Fardon, R., Strong, E. M., Weiss, F. Effect of sigma(1) receptor antagonism on ethanol and natural reward seeking Neuroreport 2012 23:809-813 DOI:10.1097/WNR.0b013e32835717c8
- Zorrilla, E. P., Wee, S., Zhao, Y., Specio, S., Boutrel, B., Koob, G. F., Weiss, F. Extended access cocaine self-administration differentially activates dorsal raphe and amygdala corticotropin-releasing factor systems in rats Addiction Biology 2012 17:300-308 DOI:10.1111/j.1369-1600.2011.00329.x PMID:21762287
- Economidou, D., Cippitelli, A., Stopponi, S., Braconi, S., Clementi, S., Ubaldi, M., Martin-Fardon, R., Weiss, F., Massi, M., Ciccocioppo, R. Activation of brain nop receptors attenuates acute and protracted alcohol withdrawal symptoms in the rat Alcoholism-Clinical and Experimental Research 2011 35:747-755 DOI:10.1111/j.1530-0277.2010.01392.x
- Kufahl, P. R., Martin-Fardon, R., Weiss, F. Enhanced sensitivity to attenuation of conditioned reinstatement by the mglur(2/3) agonist ly379268 and increased functional activity of mglur(2/3) in rats with a history of ethanol dependence Neuropsychopharmacology 2011 36:2762-2773 DOI:10.1038/npp.2011.174
- Hao, Y., Martin-Fardon, R., Weiss, F. Behavioral and functional evidence of metabotropic glutamate receptor 2/3 and metabotropic glutamate receptor 5 dysregulation in cocaine-escalated rats: Factor in the transition to dependence Biological Psychiatry 2010 68:240-248 DOI:10.1016/j.biopsych.2010.02.011
- Sidhpura, N., Weiss, F., Martin-Fardon, R. Effects of the mglu2/3 agonist ly379268 and the mglu5 antagonist mtep on ethanol seeking and reinforcement are differentially altered in rats with a history of ethanol dependence Biological Psychiatry 2010 67:804-811 DOI:10.1016/j.biopsych.2010.01.005
- Kallupi, M., Cannella, N., Economidou, D., Ubaldi, M., Ruggeri, B., Weiss, F., Massi, M., Marugan, J., Heilig, M., Bonnavion, P., de Lecea, L., Ciccocioppo, R. Neuropeptide s facilitates cue-induced relapse to cocaine seeking through activation of the hypothalamic hypocretin system Proceedings of the National Academy of Sciences of the United States of America 2010 107:19567-19572 DOI:10.1073/pnas.1004100107
- Braconi, S., Sidhpura, N., Aujla, H., Martin-Fardon, R., Weiss, F., Ciccocioppo, R. Revisiting intragastric ethanol intubation as a dependence induction method for studies of ethanol reward and motivation in rats Alcoholism-Clinical and Experimental Research 2010 34:538-544 DOI:10.1111/j.1530-0277.2009.01119.x
- Martin-Fardon, R., Zorrilla, E. P., Ciccocioppo, R., Weiss, F. Role of innate and drug-induced dysregulation of brain stress and arousal systems in addiction: Focus on corticotropin-releasing factor, nociceptin/orphanin fq, and orexin/hypocretin Brain Research 2010 1314:145-161 DOI:10.1016/j.brainres.2009.12.027
- Martin-Fardon, R., Baptista, M. A. S., Dayas, C. V., Weiss, F. Dissociation of the effects of mtep 3- (2-methyl-1,3-thiazol-4-yl)ethynyl piperidine on conditioned reinstatement and reinforcement: Comparison between cocaine and a conventional reinforcer Journal of Pharmacology and Experimental Therapeutics 2009 329:1084-1090 DOI:10.1124/jpet.109.151357
- Gilpin, N. W., Smith, A. D., Cole, M., Weiss, F., Koob, G. F., Richardson, H. N. Operant behavior and alcohol levels in blood and brain of alcohol-dependent rats Alcoholism-Clinical and Experimental Research 2009 33:2113-2123 DOI:10.1111/j.1530-0277.2009.01051.x
- Mason, B. J., Shaham, Y., Weiss, F., Le, A. D. Stress, alcohol craving, and relapse risk: Mechanisms and viable treatment targets Alcohol 2009 43:541-543 DOI:10.1016/j.alcohol.2009.09.024
- Economidou, D., Hansson, A. C., Weiss, F., Terasmaa, A., Sommer, W. H., Cippitelli, A., Fedeli, A., Martin-Fardon, R., Massi, M., Ciccocioppo, R., Heilig, M. Dysregulation of nociceptin/orphanin fq activity in the amygdala is linked to excessive alcohol drinking in the rat Biological Psychiatry 2008 64:211-218 DOI:10.1016/j.biopsych.2008.02.004
- Aujla, H., Martin-Fardon, R., Weiss, F. Rats with extended access to cocaine exhibit increased stress reactivity and sensitivity to the anxiolytic-like effects of the mglur 2/3 agonist ly379268 during abstinence Neuropsychopharmacology 2008 33:1818-1826 DOI:10.1038/sj.npp.1301588
- Dayas, C. V., McGranahan, T. M., Martin-Fardon, R., Weiss, F. Stimuli linked to ethanol availability activate hypothalamic cart and orexin neurons in a reinstatement model of relapse Biological Psychiatry 2008 63:152-157 DOI:10.1016/j.biopsych.2007.02.002
- Martin-Fardon, R., Ciccocioppo, R., Aujla, H., Weiss, F. The dorsal subiculum mediates the acquisition of conditioned reinstatement of cocaine-seeking Neuropsychopharmacology 2008 33:1827-1834 DOI:10.1038/sj.npp.1301589
- Martin-Fardon, R., Maurice, T., Aujla, H., Bowen, W. D., Weiss, F. Differential effects of sigma(1) receptor blockade on self-administration and conditioned reinstatement motivated by cocaine vs natural reward Neuropsychopharmacology 2007 32:1967-1973 DOI:10.1038/sj.npp.1301323
- Dayas, C. V., Liu, X., Simms, J. A., Weiss, F. Distinct patterns of neural activation associated with ethanol seeking: Effects of naltrexone Biological Psychiatry 2007 61:979-989 DOI:10.1016/j.biopsych.2006.07.034
- Zhao, Y., Weiss, F., Zorrilla, E. P. Remission and resurgence of anxiety-like behavior across protracted withdrawal stages in ethanol-dependent rats Alcoholism-Clinical and Experimental Research 2007 31:1505-1515 DOI:10.1111/j.1530-0277.2007.00456.x
- Gonzalez-Cuevas, G., Aujla, H., Martin-Fardon, R., Lopez-Moreno, J. A., Navarro, M., Weiss, F. Subchronic cannabinoid agonist (win 55,212-2) treatment during cocaine abstinence alters subsequent cocaine seeking behavior Neuropsychopharmacology 2007 32:2260-2266 DOI:10.1038/sj.npp.1301365
- Zhao, Y., Valdez, G. R., Fekete, E. M., Rivier, J. E., Vale, W. W., Rice, K. C., Weiss, F., Zorrilla, E. P. Subtype-selective corticotropin-releasing factor receptor agonists exert contrasting, but not opposite, effects on anxiety-related behavior in rats Journal of Pharmacology and Experimental Therapeutics 2007 323:846-854 DOI:10.1124/jpet.107.123208
- Zhao, Y., Dayas, C. V., Aujla, H., Baptista, M. A. S., Martin-Fardon, R., Weiss, F. Activation of group ii metabotropic glutamate receptors attenuates both stress and cue-induced ethanol-seeking and modulates c-fos expression in the hippocampus and amygdala Journal of Neuroscience 2006 26:9967-9974 DOI:10.1523/jneurosci.2384-06.2006
- Economidou, D., Fedeli, A., Fardon, R. M., Weiss, F., Massi, M., Ciccocioppo, R. Effect of novel nociceptin/orphanin fq-nop receptor ligands on ethanol drinking in alcohol-preferring msp rats Peptides 2006 27:3299-3306 DOI:10.1016/j.peptides.2006.09.007
- Little, H. J., Stephens, D. N., Ripley, T. L., Borlikova, G., Duka, T., Schubert, M., Albrecht, D., Becker, H. C., Lopez, M. F., Weiss, F., Drummond, C., Peoples, M., et al. Alcohol withdrawal and conditioning Alcoholism-Clinical and Experimental Research 2005 29:453-464 DOI:10.1097/01.alc.0000156737.56425.e3
- Weiss, F. Neurobiology of craving, conditioned reward and relapse Current Opinion in Pharmacology 2005 5:9-19 DOI:10.1016/j.coph.2004.11.001
- Martin-Fardon, R., Lorentz, C. U., Stuempfig, N. D., Weiss, F. Priming with btcp, a dopamine reuptake blocker, reinstates cocaine-seeking and enhances cocaine cue-induced reinstatement Pharmacology Biochemistry and Behavior 2005 82:46-54 DOI:10.1016/j.pbb.2005.07.010
- Breese, G. R., Chu, K., Dayas, C. V., Funk, D., Knapp, D. J., Koob, G. F., Le, D. A., O'Dell, L. E., Overstreet, D. H., Roberts, A. J., Sinha, R., Valdez, G. R., et al. Stress enhancement of craving during sobriety: A risk for relapse Alcoholism-Clinical and Experimental Research 2005 29:185-195 DOI:10.1097/01.alc.0000153544.83656.3c
- Ciccocioppo, R., Economidou, D., Fedeli, A., Angeletti, S., Weiss, F., Heilig, M., Massi, M. Attenuation of ethanol self-administration and of conditioned reinstatement of alcohol-seeking behaviour by the antiopioid peptide nociceptin/orphanin fq in alcohol-preferring rats Psychopharmacology 2004 172:170-178 DOI:10.1007/s00213-003-1645-1
- Dayas, C. V., Martin-Fardon, R., Thorsell, A., Weiss, F. Chronic footshock, but not a physiological stressor, suppresses the alcohol deprivation effect in dependent rats Alcohol and Alcoholism 2004 39:190-196 DOI:10.1093/alcalc/agh046
- Liu, X., Weiss, F. Nitric oxide synthesis inhibition attenuates conditioned reinstatement of ethanol-seeking, but not the primary reinforcing effects of ethanol Alcoholism-Clinical and Experimental Research 2004 28:1194-1199 DOI:10.1097/01.alc.0000134219.93192.00
- Baptista, M. A. S., Martin-Fardon, R., Weiss, F. Preferential effects of the metabotropic glutamate 2/3 receptor agonist ly379268 on conditioned reinstatement versus primary reinforcement: Comparison between cocaine and a potent conventional reinforcer Journal of Neuroscience 2004 24:4723-4727 DOI:10.1523/jneurosci.0176-04.2004
- Ciccocioppo, R., Martin-Fardon, R., Weiss, F. Stimuli associated with a single cocaine experience elicit longlasting cocaine-seeking Nature Neuroscience 2004 7:495-496 DOI:10.1038/nn1219
- Martin-Fardon, R., Lorentz, C. U., Kamenka, J. M., Weiss, F. 3-oh-pip-btcp, a metabolite of the potent da uptake blocker btcp, exerts cocaine-like action in rats Neuroreport 2003 14:2439-2444 DOI:10.1097/01.wnr.0000099608.19426.39
- Ciccocioppo, R., Lin, D., Martin-Fardon, R., Weiss, F. Reinstatement of ethanol-seeking behavior by drug cues following single versus multiple ethanol intoxication in the rat: Effects of naltrexone Psychopharmacology 2003 168:208-215 DOI:10.1007/s00213-002-1380-z
- Liu, X., Weiss, F. Stimulus conditioned to foot-shock stress reinstates alcohol-seeking behavior in an animal model of relapse Psychopharmacology 2003 168:184-191 DOI:10.1007/s00213-002-1267-z
- Ciccocioppo, R., Fedeli, A., Economidou, D., Policani, F., Weiss, F., Massi, M. The bed nucleus is a neuroanatomical substrate for the anorectic effect of corticotropin-releasing factor and for its reversal by nociceptin/orphanin fq Journal of Neuroscience 2003 23:9445-9451
- Liu, X., Weiss, F. Additive effect of stress and drug cues on reinstatement of ethanol seeking: Exacerbation by history of dependence and role of concurrent activation of corticotropin-releasing factor and opioid mechanisms Journal of Neuroscience 2002 22:7856-7861
- Weiss, F., Porrino, L. J. Behavioral neurobiology of alcohol addiction: Recent advances and challenges Journal of Neuroscience 2002 22:3332-3337
- Martin-Fardon, R., Weiss, F. Btcp is a potent reinforcer in rats: Comparison of behavior maintained on fixed- and progressive-ratio schedules Pharmacology Biochemistry and Behavior 2002 72:343-353 DOI:10.1016/s0091-3057(01)00764-x
- Ciccocioppo, R., Martin-Fardon, R., Weiss, F. Effect of selective blockade of mu(1) or delta opioid receptors on reinstatement of alcohol-seeking behavior by drug-associated stimuli in rats Neuropsychopharmacology 2002 27:391-399 DOI:10.1016/s0893-133x(02)00302-0
- Izzo, E., Martin-Fardon, R., Koob, G. F., Weiss, F., Sanna, P. P. Neural plasticity and addiction: Pi3-kinase and cocaine behavioral sensitization Nature Neuroscience 2002 5:1263-1264 DOI:10.1038/nn977
- Liu, X., Weiss, F. Reversal of ethanol-seeking behavior by d1 and d2 antagonists in an animal model of relapse: Differences in antagonist potency in previously ethanol-dependent versus nondependent rats Journal of Pharmacology and Experimental Therapeutics 2002 300:882-889 DOI:10.1124/jpet.300.3.882
- Martin-Fardon, R., Kerr, T. M., Deleuze-Masquefa, C., Kamenka, J. M., Weiss, F. Behavioral and neurochemical effects of 3-oh-pip-btcp, an active metabolite of btcp in rats Neuroreport 2001 12:4165-4169 DOI:10.1097/00001756-200112210-00060
- Zorrilla, E. P., Valdez, G. R., Weiss, F. Changes in levels of regional crf-like-immunoreactivity and plasma corticosterone during protracted drug withdrawal in dependent rats Psychopharmacology 2001 158:374-381 DOI:10.1007/s002130100773
- Ciccocioppo, R., Sanna, P. P., Weiss, F. Cocaine-predictive stimulus induces drug-seeking behavior and neural activation in limbic brain regions after multiple months of abstinence: Reversal by d-1 antagonists Proceedings of the National Academy of Sciences of the United States of America 2001 98:1976-1981 DOI:10.1073/pnas.98.4.1976
- Weiss, F., Martin-Fardon, R., Ciccocioppo, R., Kerr, T. M., Smith, D. L., Ben-Shahar, O. Enduring resistance to extinction of cocaine-seeking behavior induced by drug-related cues Neuropsychopharmacology 2001 25:361-372 DOI:10.1016/s0893-133x(01)00238-x
- Ciccocioppo, R., Angeletti, S., Weiss, F. Long-lasting resistance to extinction of response reinstatement induced by ethanol-related stimuli: Role of genetic ethanol preference Alcoholism-Clinical and Experimental Research 2001 25:1414-1419 DOI:10.1111/j.1530-0277.2001.tb02141.x
- Le, A. D., Kiianmaa, K., Cunningham, C. L., Engel, J. A., Ericson, M., Soderpalm, B., Koob, G. F., Roberts, A. J., Weiss, F., Hyytia, P., Janhunen, S., Mikkola, J., et al. Neurobiological processes in alcohol addiction Alcoholism-Clinical and Experimental Research 2001 25:144S-151S DOI:10.1111/j.1530-0277.2001.tb02389.x
- Katner, S. N., Weiss, F. Neurochemical characteristics associated with ethanol preference in selected alcohol-preferring and -nonpreferring rats: A quantitative microdialysis study Alcoholism-Clinical and Experimental Research 2001 25:198-205 DOI:10.1111/j.1530-0277.2001.tb02199.x
- Ciccocioppo, R., Martin-Fardon, R., Weiss, F., Massi, M. Nociceptin/orphanin fq inhibits stress- and crf-induced anorexia in rats Neuroreport 2001 12:1145-1149 DOI:10.1097/00001756-200105080-00019
- Suwaki, H., Kalant, H., Higuchi, S., Crabbe, J. C., Ohkuma, S., Katsura, M., Yoshimura, M., Stewart, R. C., Li, T. K., Weiss, F. Recent research on alcohol tolerance and dependence Alcoholism-Clinical and Experimental Research 2001 25:189S-196S DOI:10.1097/00000374-200105051-00031
- Richter, R. M., Zorrilla, E. P., Basso, A. M., Koob, G. F., Weiss, F. Altered amygdalar crf release and increased anxiety-like behavior in sardinian alcohol-preferring rats: A microdialysis and behavioral study Alcoholism-Clinical and Experimental Research 2000 24:1765-1772 DOI:10.1111/j.1530-0277.2000.tb01979.x
- Weiss, F., Maldonado-Vlaar, C. S., Parsons, L. H., Kerr, T. M., Smith, D. L., Ben-Shahar, O. Control of cocaine-seeking behavior by drug-associated stimuli in rats: Effects on recovery of extinguished operant-responding and extracellular dopamine levels in amygdala and nucleus accumbens Proceedings of the National Academy of Sciences of the United States of America 2000 97:4321-4326 DOI:10.1073/pnas.97.8.4321
- Ciccocioppo, R., Angeletti, S., Sanna, P. P., Weiss, F., Massi, M. Effect of nociceptin/orphanin fq on the rewarding properties of morphine European Journal of Pharmacology 2000 404:153-159 DOI:10.1016/s0014-2999(00)00590-2
- Gracy, K. N., Dankiewicz, L. A., Weiss, F., Koob, G. F. Heroin-specific stimuli reinstate operant heroin-seeking behavior in rats after prolonged extinction Pharmacology Biochemistry and Behavior 2000 65:489-494 DOI:10.1016/s0091-3057(99)00234-8
- Martin-Fardon, R., Weiss, F. N- 1-(2-benzo b thiophenyl)cyclohexyl piperidine (btcp) exerts cocaine-like actions on drug-maintained responding in rats Neuropsychopharmacology 2000 23:316-325 DOI:10.1016/s0893-133x(00)00104-4
- Martin-Fardon, R., Ciccocioppo, R., Massi, M., Weiss, F. Nociceptin prevents stress-induced ethanol- but not cocaine-seeking behavior in rats Neuroreport 2000 11:1939-1943 DOI:10.1097/00001756-200006260-00026
- Martin-Fardon, R., Ben-Shahar, O., Weiss, F. Non reciprocal cross-sensitization between cocaine and btcp on locomotor activity in the rat Pharmacology Biochemistry and Behavior 2000 66:631-635 DOI:10.1016/s0091-3057(00)00262-8
- Smith, A. D., Weiss, F. Ethanol exposure differentially alters central monoamine neurotransmission in alcohol-preferring versus -nonpreferring rats Journal of Pharmacology and Experimental Therapeutics 1999 288:1223-1228
- Katner, S. N., Weiss, F. Ethanol-associated olfactory stimuli reinstate ethanol-seeking behavior after extinction and modify extracellular dopamine levels in the nucleus accumbens Alcoholism-Clinical and Experimental Research 1999 23:1751-1760 DOI:10.1097/00000374-199911000-00007
- Richter, R. M., Weiss, F. In vivo crf release in rat amygdala is increased during cocaine withdrawal in self-administering rats Synapse 1999 32:254-261 DOI:10.1002/(sici)1098-2396(19990615)32:4<254::aid-syn2>3.0.co;2-h
- Chatman, K., Hollenbeck, T., Hagey, L., Vallee, M., Purdy, R., Weiss, F., Siuzdak, G. Nanoelectrospray mass spectrometry and precursor ion monitoring for quantitative steroid analysis and attomole sensitivity Analytical Chemistry 1999 71:2358-2363 DOI:10.1021/ac9806411
- Katner, S. N., Magalong, J. G., Weiss, F. Reinstatement of alcohol-seeking behavior by drug-associated discriminative stimuli after prolonged extinction in the rat Neuropsychopharmacology 1999 20:471-479 DOI:10.1016/s0893-133x(98)00084-0
- Parsons, L. H., Koob, G. F., Weiss, F. Ru 24969, a 5-ht1b/1a receptor agonist, potentiates cocaine-induced increases in nucleus accumbens dopamine Synapse 1999 32:132-135 DOI:10.1002/(sici)1098-2396(199905)32:2<132::aid-syn6>3.0.co;2-v
- Spanagel, R., Weiss, F. The dopamine hypothesis of reward: Past and current status Trends in Neurosciences 1999 22:521-527 DOI:10.1016/s0166-2236(99)01447-2
- Roberts, A. J., Smith, A. D., Weiss, F., Rivier, C., Koob, G. F. Estrous cycle effects on operant responding for ethanol in female rats Alcoholism-Clinical and Experimental Research 1998 22:1564-1569 DOI:10.1097/00000374-199810000-00028
- Koob, G. F., Roberts, A. J., Schulteis, G., Parsons, L. H., Heyser, C. J., Hyytia, P., Merlo-Pich, E., Weiss, F. Neurocircuitry targets in ethanol reward and dependence Alcoholism-Clinical and Experimental Research 1998 22:3-9 DOI:10.1097/00000374-199802000-00001
- Parsons, L. H., Weiss, F., Koob, G. F. Serotonin(1b) receptor stimulation enhances cocaine reinforcement Journal of Neuroscience 1998 18:10078-10089
- Parsons, L. H., Kerr, T. M., Weiss, F. Simple microbore high-performance liquid chromatographic method for the determination of dopamine and cocaine from a single in vivo brain microdialysis sample Journal of Chromatography B 1998 709:35-45 DOI:10.1016/s0378-4347(98)00024-3
- Koob, G. F., Rocio, M., Carrera, A., Gold, L. H., Heyser, C. J., Maldonado-Irizarry, C., Markou, A., Parsons, L. H., Roberts, A. J., Schulteis, G., Stinus, L., Walker, J. R., et al. Substance dependence as a compulsive behavior Journal of Psychopharmacology 1998 12:39-48 DOI:10.1177/026988119801200106
- Gonzales, R. A., Weiss, F. Suppression of ethanol-reinforced behavior by naltrexone is associated with attenuation of the ethanol-induced increase in dialysate dopamine levels in the nucleus accumbens Journal of Neuroscience 1998 18:10663-10671
- deFonseca, F. R., Carrera, M. R. A., Navarro, M., Koob, G. F., Weiss, F. Activation of corticotropin-releasing factor in the limbic system during cannabinoid withdrawal Science 1997 276:2050-2054
- Raber, J., Mehta, P. P., Kreifeldt, M., Parsons, L. H., Weiss, F., Bloom, F. E., Wilson, M. C. Coloboma hyperactive mutant mice exhibit regional and transmitter-specific deficits in neurotransmission Journal of Neurochemistry 1997 68:176-186
- Koob, G. F., Caine, S. B., Parsons, L., Markou, A., Weiss, F. Opponent process model and psychostimulant addiction Pharmacology Biochemistry and Behavior 1997 57:513-521 DOI:10.1016/s0091-3057(96)00438-8
- Weiss, F., Imperato, A., Casu, M. A., Mascia, M. S., Gessa, G. L. Opposite effects of stress on dopamine release in the limbic system of drug-naive and chronically amphetamine-treated rats European Journal of Pharmacology 1997 337:219-222 DOI:10.1016/s0014-2999(97)01264-8
- Weissenborn, R., Deroche, V., Koob, G. F., Weiss, F. Effects of dopamine agonists and antagonists on cocaine induced operant responding for a cocaine-associated stimulus Psychopharmacology 1996 126:311-322
- Katner, S. N., Kerr, T. M., Weiss, F. Ethanol anticipation enhances dopamine efflux in the nucleus accumbens of alcohol-preferring (p) but not wistar rats Behavioural Pharmacology 1996 7:669-674
- Weiss, F., Parsons, L. H., Schulteis, G., Hyytia, P., Lorang, M. T., Bloom, F. E., Koob, G. F. Ethanol self-administration restores withdrawal-associated deficiencies in accumbal dopamine and 5-hydroxytryptamine release in dependent rats Journal of Neuroscience 1996 16:3474-3485
- Parsons, L. H., Koob, G. F., Weiss, F. Extracellular serotonin is decreased in the nucleus accumbens during withdrawal from cocaine self-administration Behavioural Brain Research 1996 73:225-228
- Parsons, L. H., Caine, S. B., Sokoloff, P., Schwartz, J. C., Koob, G. F., Weiss, F. Neurochemical evidence that postsynaptic nucleus accumbens d-3 receptor stimulation enhances cocaine reinforcement Journal of Neurochemistry 1996 67:1078-1089
- Parsons, L. H., Weiss, F., Koob, G. F. Serotonin(1b) receptor stimulation enhances dopamine mediated reinforcement Psychopharmacology 1996 128:150-160 DOI:10.1007/s002130050120
- Pich, E. M., Lorang, M., Yeganeh, M., Defonseca, F. R., Raber, J., Koeb, G. F., Weiss, F. Increase of extracellular corticotropin-releasing factor-like immunoreactivity levels in the amygdala of awake rats during restraint stress and ethanol withdrawal as measured by microdialysis Journal of Neuroscience 1995 15:5439-5447
- Weissenborn, R., Yackey, M., Koob, G. F., Weiss, F. Measures of cocaine-seeking behavior using a multiple schedule of food and drug self-administration in rats Drug and Alcohol Dependence 1995 38:237-246 DOI:10.1016/0376-8716(95)01107-a
- Sanna, P. P., Weiss, F., Samson, M. E., Bloom, F. E., Pich, E. M. Rapid induction of tumor-necrosis-factor-alpha in the cerebrospinal-fluid after intracerebroventricular injection of lipopolysaccharide revealed by a sensitive capture immuno-pcb assay Proceedings of the National Academy of Sciences of the United States of America 1995 92:272-275 DOI:10.1073/pnas.92.1.272
- Richter, R. M., Pich, E. M., Koob, G. F., Weiss, F. Sensitization of cocaine-stimulated increase in extracellular levels of corticotropin-releasing factor from the rat amygdala after repeated administration as determined by intracranial microdialysis Neuroscience Letters 1995 187:169-172 DOI:10.1016/0304-3940(95)11365-4
- Parsons, L. H., Koob, G. F., Weiss, F. Serotonin dysfunction in the nucleus-accumbens of rats during withdrawal after unlimited access to intravenous cocaine Journal of Pharmacology and Experimental Therapeutics 1995 274:1182-1191
- Torres, G., Rivier, C., Weiss, F. A ketamine mixture anesthetic inhibits neuroendocrine and behavioral consequences of cocaine administration Brain Research 1994 656:33-42 DOI:10.1016/0006-8993(94)91363-3
- Markou, A., Weiss, F., Gold, L. H., Caine, S. B., Schulteis, G., Koob, G. F. Animal-models of drug craving Psychopharmacology 1993 112:163-182 DOI:10.1007/bf02244907
- Pich, E. M., Koob, G. F., Heilig, M., Menzaghi, F., Vale, W., Weiss, F. Corticotropin-releasing factor release from the mediobasal hypothalamus of the rat as measured by microdialysis Neuroscience 1993 55:695-707 DOI:10.1016/0306-4522(93)90435-i
- Weiss, F., Lorang, M. T., Bloom, F. E., Koob, G. F. Oral alcohol self-administration stimulates dopamine release in the rat nucleus-accumbens - genetic and motivational determinants Journal of Pharmacology and Experimental Therapeutics 1993 267:250-258
- Weiss, F., Markou, A., Lorang, M. T., Koob, G. F. Basal extracellular dopamine levels in the nucleus-accumbens are decreased during cocaine withdrawal after unlimited-access self-administration Brain Research 1992 593:314-318 DOI:10.1016/0006-8993(92)91327-b
- Weiss, F., Paulus, M. P., Lorang, M. T., Koob, G. F. Increases in extracellular dopamine in the nucleus-accumbens by cocaine are inversely related to basal levels - effects of acute and repeated administration Journal of Neuroscience 1992 12:4372-4380
- Weiss, F., Hurd, Y. L., Ungerstedt, U., Markou, A., Plotsky, P. M., Koob, G. F. Neurochemical correlates of cocaine and ethanol self-administration Annals of the New York Academy of Sciences 1992 654:220-241 DOI:10.1111/j.1749-6632.1992.tb25970.x
- Weiss, F., Mitchiner, M., Bloom, F. E., Koob, G. F. Free-choice responding for ethanol versus water in alcohol preferring (p) and unselected wistar rats is differentially modified by naloxone, bromocriptine, and methysergide Psychopharmacology 1990 101:178-186 DOI:10.1007/bf02244123
- Koob, G. F., Weiss, F. Pharmacology of drug self-administration Alcohol 1990 7:193-197 DOI:10.1016/0741-8329(90)90004-v
- Hurd, Y. L., Weiss, F., Koob, G., Ungerstedt, U. The influence of cocaine self-administration on invivo dopamine and acetylcholine neurotransmission in rat caudate-putamen Neuroscience Letters 1990 109:227-233 DOI:10.1016/0304-3940(90)90568-t
- Weiss, F., Ettenberg, A., Koob, G. F. Cck-8 injected into the nucleus accumbens attenuates the supersensitive locomotor response to apomorphine in 6-ohda and chronic-neuroleptic treated rats Psychopharmacology 1989 99:409-415 DOI:10.1007/bf00445568
- Hurd, Y. L., Weiss, F., Koob, G. F., And, N. E., Ungerstedt, U. Cocaine reinforcement and extracellular dopamine overflow in rat nucleus accumbens - an invivo microdialysis study Brain Research 1989 498:199-203 DOI:10.1016/0006-8993(89)90422-8
- Weiss, F., Tanzer, D. J., Ettenberg, A. Opposite actions of cck-8 on amphetamine-induced hyperlocomotion and stereotypy following intracerebroventricular and intra-accumbens injections in rats Pharmacology Biochemistry and Behavior 1988 30:309-317 DOI:10.1016/0091-3057(88)90460-1
- Weiss, F., Ettenberg, A. Comparison of circling induced by unilateral intrastriatal microinjections of haloperidol, clozapine and cck-8 in rats Pharmacology Biochemistry and Behavior 1986 24:983-989 DOI:10.1016/0091-3057(86)90446-6
Research
research overview
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Neurobiology of Drug and Alcohol Addiction
Work in our laboratory is concerned with the neurobiological basis of abnormal behavioral and brain functions relevant to human psychopathology with emphasis on the neural control of motivation and reinforcement. The majority of this work is directed at the understanding of the neuropharmcological, neurocircuitry, and molecular basis of drug and alcohol addiction including mechanisms that lead to the development of dependence and withdrawal states, drug craving, relapse as well as impairment in memory and cognitive function.
principal investigator on
Background
education and training
- Ph.D. in Biological Psychology, University of California, Santa Barbara 1986