Publications in VIVO

Co-Author Network

Co-Investigator Network

McDonald, Patricia Faculty Member

Positions

Associate Scientific Director I, Translational Research Institute, The Scripps Research Institute 2005 -
Assistant Professor of Molecular Therapeutics (Joint Appointment), Molecular Therapeutics, The Scripps Research Institute 2010 -
Research Scientist, Eli Lilly & Company 2002 - 2005
Senior Scientist, DuPont Pharmaceuticals 2000 - 2002
Senior Postdoctoral Fellow, School of Medicine, Duke University 1995 - 2000
Postdoctoral Fellow, University of Glasgow 1993 - 1994

Dr. Patricia McDonald focuses on the development of biochemical and cell-based functional assays to identify and develop small molecule modulators of GPCRs for the treatment of metabolic and CNS disorders.

Publications

selected publications

academic article
- Sturchler, E., Feurstein, D., Chen, W. M., McDonald, P., Duckett, D. Stress-induced nuclear import of apoptosis signal-regulating kinase 1 is mediated by karyopherin alpha 2/beta 1 heterodimer Biochimica Et Biophysica Acta-Molecular Cell Research 2013 1833:583-592 DOI:10.1016/j.bbamcr.2012.10.023
- Jiang, R., Song, X. Y., Bali, P., Smith, A., Bayona, C. R., Lin, L., Cameron, M. D., McDonald, P. H., Kenny, P. J., Kamenecka, T. M. Disubstituted piperidines as potent orexin (hypocretin) receptor antagonists Bioorganic & Medicinal Chemistry Letters 2012 22:3890-3894 DOI:10.1016/j.bmcl.2012.04.122
- Begriche, K., Marston, O. J., Rossi, J., Burke, L. K., McDonald, P., Heisler, L. K., Butler, A. A. Melanocortin-3 receptors are involved in adaptation to restricted feeding Genes Brain and Behavior 2012 11:291-302 DOI:10.1111/j.1601-183X.2012.00766.x PMID:22353545
- Sturchler, E., Feurstein, D., McDonald, P., Duckett, D. Mechanism of oxidative stress-induced ask1-catalyzed mkk6 phosphorylation Biochemistry 2010 49:4094-4102 DOI:10.1021/bi100010j
- Brothers, S. P., Saldanha, S. A., Spicer, T. P., Cameron, M., Mercer, B. A., Chase, P., McDonald, P., Wahlestedt, C., Hodder, P. S. Selective and brain penetrant neuropeptide y y2 receptor antagonists discovered by whole-cell high-throughput screening Molecular Pharmacology 2010 77:46-57 DOI:10.1124/mol.109.058677
- Berglund, M. M., Schober, D. A., Statnick, M. A., McDonald, P. H., Gehlert, D. R. The use of bioluminescence resonance energy transfer 2 to study neuropeptide y receptor agonist-induced beta-arrestin 2 interaction Journal of Pharmacology and Experimental Therapeutics 2003 306:147-156 DOI:10.1124/jpet.103.051227
- Kohout, T. A., Takaoka, H., McDonald, P. H., Perry, S. J., Mao, L., Lefkowitz, R. J., Rockman, H. A. Augmentation of cardiac contractility mediated by the human beta(3)-adrenergic receptor overexpressed in the hearts of transgenic mice Circulation 2001 104:2485-2491 DOI:10.1161/hc4501.098933
- McDonald, P. H., Lefkowitz, R. J. Beta arrestins: New roles in regulating heptahelical receptors' functions Cellular Signalling 2001 13:683-689 DOI:10.1016/s0898-6568(01)00203-0
- Miller, W. E., McDonald, P. H., Cai, S. F., Field, M. E., Davis, R. J., Lefkowitz, R. J. Identification of a motif in the carboxyl terminus of beta-arrestin2 responsible for activation of jnk3 Journal of Biological Chemistry 2001 276:27770-27777 DOI:10.1074/jbc.M102264200
- Shenoy, S. K., McDonald, P. H., Kohout, T. A., Lefkowitz, R. J. Regulation of receptor fate by ubiquitination of activated beta(2)-adrenergic receptor and beta-arrestin Science 2001 294:1307-1313 DOI:10.1126/science.1063866
- McDonald, P. H., Chow, C. W., Miller, W. E., Laporte, S. A., Field, M. E., Lin, F. T., Davis, R. J., Lefkowitz, R. J. Beta-arrestin 2: A receptor-regulated mapk scaffold for the activation of jnk3 Science 2000 290:1574-1577 DOI:10.1126/science.290.5496.1574
- Kypson, A. P., Hendrickson, S. C., Akhter, S. A., Wilson, K., McDonald, P. H., Lilly, R. E., Dolber, P. C., Glower, D. D., Lefkowitz, R. J., Koch, W. J. Adenovirus-mediated gene transfer of the beta(2)-adrenergic receptor to donor hearts enhances cardiac function Gene Therapy 1999 6:1298-1304 DOI:10.1038/sj.gt.3300940
- Maurice, J. P., Hata, J. A., Shah, A. S., White, D. C., McDonald, P. H., Dolber, P. C., Wilson, K. H., Lefkowitz, R. J., Glower, D. D., Koch, W. J. Enhancement of cardiac function after adenoviral-mediated in vivo intracoronary beta(2)-adrenergic receptor gene delivery Journal of Clinical Investigation 1999 104:21-29 DOI:10.1172/jci6026
- Alexander, M. Y., Webster, K. A., McDonald, P. H., Prentice, H. M. Gene transfer and models of gene therapy for the myocardium Clinical and Experimental Pharmacology and Physiology 1999 26:661-668 DOI:10.1046/j.1440-1681.1999.03117.x
- McDonald, P. H., Cote, N. L., Lin, F. T., Premont, R. T., Pitcher, J. A., Lefkowitz, R. J. Identification of nsf as a beta-arrestin1-binding protein - implications for beta(2)-adrenergic receptor regulation Journal of Biological Chemistry 1999 274:10677-10680 DOI:10.1074/jbc.274.16.10677
- Peppel, K., Boekhoff, I., McDonald, P., Breer, H., Caron, M. G., Lefkowitz, R. J. G protein-coupled receptor kinase 3 (grk3) gene disruption leads to loss of odorant receptor desensitization Journal of Biological Chemistry 1997 272:25425-25428 DOI:10.1074/jbc.272.41.25425
- Akhter, S. A., Skaer, C. A., Kypson, A. P., McDonald, P. H., Peppel, K. C., Glower, D. D., Lefkowitz, R. J., Koch, W. J. Restoration of beta-adrenergic signaling in failing cardiac ventricular myocytes via adenoviral-mediated gene transfer Proceedings of the National Academy of Sciences of the United States of America 1997 94:12100-12105 DOI:10.1073/pnas.94.22.12100 PMID:9342369

featured in

Scripps Research Institute Scientists in Florida Awarded $2.3 Million NIH Grant to Develop New Treatments for Drug Addiction

Research

research overview

G-protein-coupled receptors (GPCRs) represent the largest and most versatile family of cell surface receptors. The ubiquitous cell surface distribution and involvement of these proteins in virtually all biological processes accounts for the fact that the largest percentage of currently marketed therapeutic drugs target GPCRs. Work in our laboratory is focused on the development of biochemical and cell-based functional assays to monitor GPCR activity using both high throughput and high content technologies. In collaboration with other disciplines such as chemistry, DMPK and in vivo pharmacology we aim to identify and develop small molecule modulators of GPCRs for the therapeutic treatment of metabolic and CNS disorders.

principal investigator on

A novel approach to enable a HTS-compatible galanin 3 receptor cell-based assay awarded by Office of the Director 2009 - 2011
Development of chemical probes to investigate the role of ntsr1 in cns disorders awarded by National Institute on Drug Abuse 2010 - 2015
Development of second messenger; trafficking; and functional assays for gpr119 awarded by National Institute of Diabetes and Digestive and Kidney Diseases 2010 - 2013

Background

education and training

Ph.D., The University of Dundee 1993
B.S., University of North London 1989