academic article

• Hsu, Y., Lu, X. A., Zulueta, M. M. L., Tsai, C. M., Lin, K. I., Hung, S. C., Wong, C. H.  Acyl and silyl group effects in reactivity-based one-pot glycosylation: Synthesis of embryonic stem cell surface carbohydrates lc(4) and iv(2)fuc-lc(4)  Journal of the American Chemical Society  2012 134:4549-4552  DOI:10.1021/ja300284x
• Galluzzi, L., Vitale, I., Abrams, J. M., Alnemri, E. S., Baehrecke, E. H., Blagosklonny, M. V., Dawson, T. M., Dawson, V. L., El-Deiry, W. S., Fulda, S., Gottlieb, E., Green, D. R., et al.  Molecular definitions of cell death subroutines: Recommendations of the nomenclature committee on cell death 2012  Cell Death and Differentiation  2012 19:107-120  DOI:10.1038/cdd.2011.96
• Bajo, M., Madamba, S. G., Lu, X. Y., Sharkey, L. M., Bartfai, T., Siggins, G. R.  Receptor subtype-dependent galanin actions on gamma-aminobutyric acidergic neurotransmission and ethanol responses in the central amygdala  Addiction Biology  2012 17:694-705  DOI:10.1111/j.1369-1600.2011.00360.x  PMID:21955024
• Jiang, C. L., Parrish, N. F., Wilen, C. B., Li, H., Chen, Y., Pavlicek, J. W., Berg, A., Lu, X. Z., Song, H. S., Tilton, J. C., Pfaff, J. M., Henning, E. A., et al.  Primary infection by a human immunodeficiency virus with atypical coreceptor tropism  Journal of Virology  2011 85:10669-10681  DOI:10.1128/jvi.05249-11
• Sagi, V. N., Liu, T. Y., Lu, X. Y., Bartfai, T., Roberts, E.  Synthesis and biological evaluation of novel pyrimidine derivatives as sub-micromolar affinity ligands of galr2  Bioorganic & Medicinal Chemistry Letters  2011 21:7210-7215  DOI:10.1016/j.bmcl.2011.09.033  PMID:22018787
• Zahid, M., Lu, X. L., Mi, Z. B., Robbins, P. D.  Cationic and tissue-specific protein transduction domains: Identification, characterization, and therapeutic application  Advances in Genetics  2010 69:83-95  DOI:10.1016/s0065-2660(10)69007-4  PMID:20807603
• Lu, X. Y., Roberts, E., Xia, F. C., Sanchez-Alavez, M., Liu, T. Y., Baldwin, R., Wu, S., Chang, J., Wasterlain, C. G., Bartfai, T.  Galr2-positive allosteric modulator exhibits anticonvulsant effects in animal models  Proceedings of the National Academy of Sciences of the United States of America  2010 107:15229-15234  DOI:10.1073/pnas.1008986107  PMID:20660766
• Levy, D., Neuhausen, S. L., Hunt, S. C., Kimura, M., Hwang, S. J., Chen, W., Bis, J. C., Fitzpatrick, A. L., Smith, E., Johnson, A. D., Gardner, J. P., Srinivasan, S. R., et al.  Genome-wide association identifies obfc1 as a locus involved in human leukocyte telomere biology  Proceedings of the National Academy of Sciences of the United States of America  2010 107:9293-9298  DOI:10.1073/pnas.0911494107
• Lu, X. Y., Bartfai, T.  Analyzing the validity of galr1 and galr2 antibodies using knockout mice  Naunyn-Schmiedebergs Archives of Pharmacology  2009 379:417-420  DOI:10.1007/s00210-009-0394-z
• Mitsukawa, K., Lu, X., Bartfai, T.  Bidirectional regulation of stress responses by galanin in mice: Involvement of galanin receptor subtype 1  Neuroscience  2009 160:837-846  DOI:10.1016/j.neuroscience.2009.02.063
• Sun, F., Mi, Z. B., Condliffe, S. B., Bertrand, C. A., Gong, X. Y., Lu, X. L., Zhang, R. L., Latoche, J. D., Pilewski, J. M., Robbins, P. D., Frizzell, R. A.  Chaperone displacement from mutant cystic fibrosis transmembrane conductance regulator restores its function in human airway epithelia  FASEB Journal  2008 22:3255-3263  DOI:10.1096/fj.07-105338
• Miermont, A., Barnhill, H., Strable, E., Lu, X. W., Wall, K. A., Wang, Q., Finn, M. G., Huang, X. F.  Cowpea mosaic virus capsid: A promising carrier for the development of carbohydrate based antitumor vaccines  Chemistry-a European Journal  2008 14:4939-4947  DOI:10.1002/chem.200800203
• Lu, X. H., Vogt, P. K., Boger, D. L., Lunec, J.  Disruption of the myc transcriptional function by a small-molecule antagonist of myc/max dimerization  Oncology Reports  2008 19:825-830
• Mitsukawa, K., Lu, X., Bartfai, T.  Galanin, galanin receptors and drug targets  Cellular and Molecular Life Sciences  2008 65:1796-1805  DOI:10.1007/s00018-008-8153-8
• Lu, X. Y., Ross, B., Sanchez-Alavez, M., Zorrilla, E. P., Bartfai, T.  Phenotypic analysis of galr2 knockout mice in anxiety- and depression-related behavioral tests  Neuropeptides  2008 42:387-397  DOI:10.1016/j.npep.2008.04.009
• Zorrilla, E. P., Brennan, M., Sabino, V., Lu, X., Bartfal, T.  Galanin type 1 receptor knockout mice show altered responses to high-fat diet and glucose challenge  Physiology & Behavior  2007 91:479-485  DOI:10.1016/j.physbeh.2006.11.011
• Conti, B., Maier, R., Barr, A. M., Morale, M. C., Lu, X., Sanna, P. P., Bilbe, G., Hoyer, D., Bartfai, T.  Region-specific transcriptional changes following the three antidepressant treatments electro convulsive therapy, sleep deprivation and fluoxetine  Molecular Psychiatry  2007 12:167-189  DOI:10.1038/sj.mp.4001897
• Barr, A. M., Kinney, J. W., Hill, M. N., Lu, X. Y., Biros, S., Rebek, J., Bartfai, T.  A novel, systemically active, selective galanin receptor type-3 ligand exhibits antidepressant-like activity in preclinical tests  Neuroscience Letters  2006 405:111-115  DOI:10.1016/j.neulet.2006.06.033
• Gao, W. T., Soloff, A. C., Lu, X. H., Montecalvo, A., Nguyen, D. C., Matsuoka, Y., Robbins, P. D., Swayne, D. E., Donis, R. O., Katz, J. M., Barratt-Boyes, S. M., Gambotto, A.  Protection of mice and poultry from lethal h5n1 avian influenza virus through adenovirus-based immunization  Journal of Virology  2006 80:1959-1964  DOI:10.1128/jvi.80.4.1959-1964.2006
• Shi, T. J. S., Hua, X. Y., Lu, X. Y., Malkmus, S., Kinney, J., Holmberg, K., Wirz, S., Ceccatelli, S., Yaksh, T., Bartfai, T., Hokfelt, T.  Sensory neuronal phenotype in galanin receptor 2 knockout mice: Focus on dorsal root ganglion neurone development and pain behaviour  European Journal of Neuroscience  2006 23:627-636  DOI:10.1111/j.1460-9568.2006.04593.x
• Lu, X. Y., Barr, A. M., Kinney, J. W., Sanna, P., Conti, B., Behrens, M. M., Bartfai, T.  A role for galanin in antidepressant actions with a focus on the dorsal raphe nucleus  Proceedings of the National Academy of Sciences of the United States of America  2005 102:874-879  DOI:10.1073/pnas.0408891102
• Zhang, Q. G., Xu, W., Lu, X. Y.  Cycloisomerization of 1,6-enynes using acetate as a nucleophile under palladium(ii) catalysis  Journal of Organic Chemistry  2005 70:1505-1507  DOI:10.1021/jo048414o
• Lu, X. Y., Mazarati, A., Sanna, P., Shinmei, S., Bartfai, T.  Distribution and differential regulation of galanin receptor subtypes in rat brain: Effects of seizure activity  Neuropeptides  2005 39:147-152  DOI:10.1016/j.mpep.2004.12.011
• Lu, X. Y., Lundstrom, L., Bartfai, T.  Galanin (2-11) binds to galr3 in transfected cell lines: Limitations for pharmacological definition of receptor subtypes  Neuropeptides  2005 39:165-167  DOI:10.1016/j.npep.2004.12.013
• Lu, X. Y., Lundstrom, L., Langel, U., Bartfai, T.  Galanin receptor ligands  Neuropeptides  2005 39:143-146  DOI:10.1016/j.mpep.2004.12.012
• Lu, X. Y., Barr, A. M., Bartfai, T.  Galanin receptors as novel drug targets for the treatment of depression and anxiety  Drug Development Research  2005 65:227-236  DOI:10.1002/ddr.20026
• Wirz, S. A., Davis, C. N., Lu, X. Y., Zal, T., Bartfai, T.  Homodimerization and internalization of galanin type 1 receptor in living cho cells  Neuropeptides  2005 39:535-546  DOI:10.1016/j.npep.2005.09.001
• Lundstrom, L., Lu, X. Y., Langel, U., Bartfai, T.  Important pharmacophores for binding to galanin receptor 2  Neuropeptides  2005 39:169-171  DOI:10.1016/j.npep.2004.12.029
• Malkmus, S., Lu, X., Bartfai, T., Yaksh, T. L., Hua, X. Y.  Increased hyperalgesia after tissue injury and faster recovery of allodynia after nerve injury in the galr1 knockout mice  Neuropeptides  2005 39:217-221  DOI:10.1016/j.npep.2004.12.002
• Jourdi, H., Lu, X. Y., Yanagihara, T., Lauterborn, J. C., Bi, X. N., Gall, C. M., Baudry, M.  Prolonged positive modulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (ampa) receptors induces calpain-mediated psd-95/dlg/zo-1 protein degradation and ampa receptor down-regulation in cultured hippocampal slices  Journal of Pharmacology and Experimental Therapeutics  2005 314:16-26  DOI:10.1124/jpet.105.083873
• Mazarati, A., Lu, X. Y.  Regulation of limbic status epilepticus by hippocampal galanin type 1 and type 2 receptors  Neuropeptides  2005 39:277-280  DOI:10.1016/j.npep.2004.12.003
• Badie-Mahdavi, H., Lu, X., Behrens, M. M., Bartfai, T.  Role of galanin receptor 1 and galanin receptor 2 activation in synaptic plasticity associated with 3 ',5 '-cyclic amp response element-binding protein phosphorylation in the dentate gyrus: Studies with a galanin receptor 2 agonist and galanin receptor 1 knockout mice  Neuroscience  2005 133:591-604  DOI:10.1016/j.neuroscience.2005.02.042
• Mazarati, A., Lu, X. Y., Kilk, K., Langel, U., Wasterlain, C., Bartfai, T.  Galanin type 2 receptors regulate neuronal survival, susceptibility to seizures and seizure-induced neurogenesis in the dentate gyrus  European Journal of Neuroscience  2004 19:3235-3244  DOI:10.1111/j.1460-9568.2004.03449.x
• Bartfai, T., Lu, X. Y., Badie-Mahdavi, H., Barr, A. M., Mazarati, A., Hua, X. Y., Yaksh, T., Haberhauer, G., Ceide, S. C., Trembleau, L., Somogyi, L., Krock, L., et al.  Galmic, a nonpeptide galanin receptor agonist, affects behaviors in seizure, pain, and forced-swim tests  Proceedings of the National Academy of Sciences of the United States of America  2004 101:10470-10475  DOI:10.1073/pnas.0403802101
• Mazarati, A., Lu, X., Shinmei, S., Badie-Mahdavi, H., Bartfai, T.  Patterns of seizures, hippocampal injury and neurogenesis in three models of status epilepticus in galanin receptor type 1 (galr1) knockout mice  Neuroscience  2004 128:431-441  DOI:10.1016/j.neuroscience.2004.06.052
• Ceide, S. C., Trembleau, L., Haberhauer, G., Somogyi, L., Lu, X. Y., Bartfai, T., Rebek, J.  Synthesis of galmic: A nonpeptide galanin receptor agonist  Proceedings of the National Academy of Sciences of the United States of America  2004 101:16727-16732  DOI:10.1073/pnas.0407543101
• Mi, Z. B., Lu, X. L., Mai, J. C., Bobby, G. N., Wang, G. Q., Lechman, E. R., Watkins, S. C., Rabinowich, H., Robbins, P. D.  Identification of a synovial fibroblast-specific protein transduction domain for delivery of apoptotic agents to hyperplastic synovium  Molecular Therapy  2003 8:295-305  DOI:10.1016/s1525-016(03)00181-3
• Lu, X. Y., Zhang, Q. H.  Effect of ligands on the divalent palladium-catalyzed carbon-carbon coupling reactions. Highly enantioselective synthesis of optically active gamma-butyrolactones  Pure and Applied Chemistry  2001 73:247-250  DOI:10.1351/pac200173020247
• Zhang, Q. H., Lu, X. Y., Han, X. L.  Palladium(ii)-catalyzed asymmetric cyclization of (z)-4 '-acetoxy-2 '-butenyl 2-alkynoates. Role of nitrogen-containing ligands in palladium(ii)-mediated reactions  Journal of Organic Chemistry  2001 66:7676-7684  DOI:10.1021/jo0105181
• Lu, X. Y., Wyszynski, M., Sheng, M., Baudry, M.  Proteolysis of glutamate receptor-interacting protein by calpain in rat brain: Implications for synaptic plasticity  Journal of Neurochemistry  2001 77:1553-1560  DOI:10.1046/j.1471-4159.2001.00359.x
• Zhang, Q. H., Lu, X. Y.  Reactions of palladium enolate intermediate with electrophiles under divalent palladium catalysis  Acta Chimica Sinica  2001 59:1702-1706
• Zhang, Z. G., Lu, X. Y., Xu, Z. R., Zhang, Q. H., Han, X. L.  Role of halide ions in divalent palladium-mediated reactions: Competition between beta-heteroatom elimination and beta-hydride elimination of a carbon-palladium bond  Organometallics  2001 20:3724-3728  DOI:10.1021/om0101994
• Rong, Y. Q., Lu, X. Y., Bernard, A., Khrestchatisky, M., Baudry, M.  Tyrosine phosphorylation of ionotropic glutamate receptors by fyn or src differentially modulates their susceptibility to calpain and enhances their binding to spectrin and psd-95  Journal of Neurochemistry  2001 79:382-390  DOI:10.1046/j.1471-4159.2001.00565.x
• Lu, X. Y., Rong, Y. Q., Baudry, M.  Calpain-mediated degradation of psd-95 in developing and adult rat brain  Neuroscience Letters  2000 286:149-153  DOI:10.1016/s0304-3940(00)01101-0
• Lu, X. Y., Rong, Y. Q., Bi, R. F., Baudry, M.  Calpain-mediated truncation of rat brain ampa receptors increases their triton x-100 solubility  Brain Research  2000 863:143-150  DOI:10.1016/s0006-8993(00)02112-0
• Mi, Z. B., Mai, J., Lu, X. L., Robbins, P. D.  Characterization of a class of cationic peptides able to facilitate efficient protein transduction in vitro and in vivo  Molecular Therapy  2000 2:339-347  DOI:10.1006/mthe.2000.0137
• Zhang, Q. H., Lu, X. Y.  Highly enantioselective palladium(ii)-catalyzed cyclization of (z)-4 '-acetoxy-2 '-butenyl 2-alkynoates: An efficient synthesis of optically active gamma-butyrolactones  Journal of the American Chemical Society  2000 122:7604-7605  DOI:10.1021/ja001379s
• Lu, X. P., Koch, K. S., Lew, D. J., Dulic, V., Pines, J., Reed, S. I., Hunter, T., Leffert, H. L.  Induction of cyclin messenger-rna and cyclin-associated histone-h1 kinase during liver-regeneration  Journal of Biological Chemistry  1992 267:2841-2844