Hodder, Peter
Faculty Member
Positions
Associate Professor of Molecular Therapeutics (Joint Appointment),
Molecular Therapeutics ,
The Scripps Research Institute 2007 -
Senior Scientific Director,
Translational Research Institute ,
The Scripps Research Institute 2005 -
Director, Lead Identification,
Translational Research Institute ,
The Scripps Research Institute 2005 -
Adjunct Professor of Electrical Engineering & Bioengineering, Department of Electrical Engineering,
Florida Atlantic University 2005 -
Director,
Molecular Screening Center ,
The Scripps Research Institute 2005 - 2012
Research Fellow, Department of Automated Biotechnology, Merck Research Laboratories,
Merck & Co., Inc. 2003 - 2005
Senior Research Biochemist, Department of Automated Biotechnology, Merck Research Laboratories,
Merck & Co., Inc. 1999 - 2003
Research Areas
Affiliation
head of
Publications
selected publications
academic article
Jacobs, J., Grum-Tokars, V., Zhou, Y., Turlington, M., Saldanha, S. A., Chase, P., Eggler, A., Dawson, E. S., Baez-Santos, Y. M., Tomar, S., Mielech, A. M., Baker, S. C., et al.
Discovery, synthesis, and structure-based optimization of a series of n-(tert-butyl)-2-(n-arylamido)-2-(pyridin-3-yl) acetamides (ml188) as potent noncovalent small molecule inhibitors of the severe acute respiratory syndrome coronavirus (sars-cov) 3cl protease
Journal of Medicinal Chemistry
2013
56:534-546
DOI: 10.1021/jm301580n
Nagano, J. M. G., Hsu, K. L., Whitby, L. R., Niphakis, M. J., Speers, A. E., Brown, S. J., Spicer, T., Fernandez-Vega, V., Ferguson, J., Hodder, P., Srinivasan, P., Gonzalez, T. D., et al.
Selective inhibitors and tailored activity probes for lipoprotein-associated phospholipase A(2)
Bioorganic & Medicinal Chemistry Letters
2013
23:839-843
DOI: 10.1016/j.bmcl.2012.11.061
PMID: 23260346
Adibekian, A., Martin, B. R., Chang, J. W., Hsu, K. L., Tsuboi, K., Bachovchin, D. A., Speers, A. E., Brown, S. J., Spicer, T., Fernandez-Vega, V., Ferguson, J., Hodder, P. S., et al.
Confirming target engagement for reversible inhibitors in vivo by kinetically tuned activity-based probes
Journal of the American Chemical Society
2012
134:10345-10348
DOI: 10.1021/ja303400u
PMID: 22690931
Urbano, M., Guerrero, M., Zhao, J., Velaparthi, S., Saldanha, S. A., Chase, P., Wang, Z. W., Civelli, O., Hodder, P., Schaeffer, M. T., Brown, S., Rosen, H., et al.
Design, synthesis and SAR analysis of novel potent and selective small molecule antagonists of NPBWR1 (GPR7)
Bioorganic & Medicinal Chemistry Letters
2012
22:7135-7141
DOI: 10.1016/j.bmcl.2012.09.074
PMID: 23079522
Guerrero, M., Urbano, M., Zhao, J., Crisp, M., Chase, P., Hodder, P., Schaeffer, M. T., Brown, S., Rosen, H., Roberts, E.
Discovery, design and synthesis of novel potent and selective sphingosine-1-phosphate 4 receptor (s1p(4)-r) agonists
Bioorganic & Medicinal Chemistry Letters
2012
22:537-542
DOI: 10.1016/j.bmcl.2011.10.096
PMID: 22119461
Amundsen, S. K., Spicer, T., Karabulut, A. C., Londono, L. M., Eberhart, C., Vega, V. F., Bannister, T. D., Hodder, P., Smith, G. R.
Small-molecule inhibitors of bacterial addab and recbcd helicase-nuclease DNA repair enzymes
ACS Chemical Biology
2012
7:879-891
DOI: 10.1021/cb300018x
PMID: 22443934
Calamini, B., Silva, M. C., Madoux, F., Hutt, D. M., Khanna, S., Chalfant, M. A., Saldanha, S. A., Hodder, P., Tait, B. D., Garza, D., Balch, W. E., Morimoto, R. I.
Small-molecule proteostasis regulators for protein conformational diseases
Nature Chemical Biology
2012
8:185-196
DOI: 10.1038/nchembio.763
Peatey, C. L., Spicer, T. P., Hodder, P. S., Trenholme, K. R., Gardiner, D. L.
A high-throughput assay for the identification of drugs against late-stage plasmodium falciparum gametocytes
Molecular and Biochemical Parasitology
2011
180:127-131
DOI: 10.1016/j.molbiopara.2011.09.002
Lone, A. M., Bachovchin, D. A., Westwood, D. B., Speers, A. E., Spicer, T. P., Fernandez-Vega, V., Chase, P., Hodder, P. S., Rosen, H., Cravatt, B. F., Saghatelian, A.
A substrate-free activity-based protein profiling screen for the discovery of selective prepl inhibitors
Journal of the American Chemical Society
2011
133:11665-11674
DOI: 10.1021/ja2036095
PMID: 21692504
Bachovchin, D. A., Mohr, J. T., Speers, A. E., Wang, C., Berlin, J. M., Spicer, T. P., Fernandez-Vega, V., Chase, P., Hodder, P. S., Schurer, S. C., Nomura, D. K., Rosen, H., et al.
Academic cross-fertilization by public screening yields a remarkable class of protein phosphatase methylesterase-1 inhibitors
Proceedings of the National Academy of Sciences of the United States of America
2011
108:6811-6816
DOI: 10.1073/pnas.1015248108
PMID: 21398589
Istrate, M. A., Spicer, T. P., Wang, Y., Bernard, J. A., Helvering, L. M., Bocchinfuso, W. P., Richardson, T. I., Zink, R., Kumar, N., Montrose-Rafizadeh, C., Dodge, J., Hodder, P., et al.
Development of an hts-compatible assay for discovery of ror alpha modulators using alphascreen (r) technology
Journal of Biomolecular Screening
2011
16:183-191
DOI: 10.1177/1087057110389040
Urbano, M., Guerrero, M., Velaparthi, S., Crisp, M., Chase, P., Hodder, P., Schaeffer, M. T., Brown, S., Rosen, H., Roberts, E.
Discovery, synthesis and sar analysis of novel selective small molecule s1p(4)-r agonists based on a (2z,5z)-5-((pyrrol-3-yl)methylene)-3-alkyl-2-(alkylimino)thiazolidin-4-o ne chemotype
Bioorganic & Medicinal Chemistry Letters
2011
21:6739-6745
DOI: 10.1016/j.bmcl.2011.09.049
PMID: 21982495
Roth, J., Minond, D., Darout, E., Liu, Q., Lauer, J., Hodder, P., Fields, G. B., Roush, W. R.
Identification of novel, exosite-binding matrix metalloproteinase-13 inhibitor scaffolds
Bioorganic & Medicinal Chemistry Letters
2011
21:7180-7184
DOI: 10.1016/j.bmcl.2011.09.077
Bialkowska, A. B., Crisp, M., Bannister, T., He, Y. J., Chowdhury, S., Schurer, S., Chase, P., Spicer, T., Madoux, F., Tian, C. L., Hodder, P., Zaharevitz, D., et al.
Identification of small-molecule inhibitors of the colorectal cancer oncogene kruppel-like factor 5 expression by ultrahigh-throughput screening
Molecular Cancer Therapeutics
2011
10:2043-2051
DOI: 10.1158/1535-7163.mct-11-0550
Baillargeon, P., Scampavia, L., Einsteder, R., Hodder, P.
Monitoring of hts compound library quality via a high-resolution image acquisition and processing instrument
JALA
2011
16:197-203
DOI: 10.1016/j.jala.2011.02.004
Tsuboi, K., Bachovchin, D. A., Speers, A. E., Spicer, T. P., Fernandez-Vega, V., Hodder, P., Rosen, H., Cravatt, B. F.
Potent and selective inhibitors of glutathione s-transferase omega 1 that impair cancer drug resistance
Journal of the American Chemical Society
2011
133:16605-16616
DOI: 10.1021/ja2066972
PMID: 21899313
Chou, T. F., Brown, S. J., Minond, D., Nordin, B. E., Li, K. L., Jones, A. C., Chase, P., Porubsky, P. R., Stoltz, B. M., Schoenen, F. J., Patricelli, M. P., Hodder, P., et al.
Reversible inhibitor of p97, dbeq, impairs both ubiquitin-dependent and autophagic protein clearance pathways
Proceedings of the National Academy of Sciences of the United States of America
2011
108:4834-4839
DOI: 10.1073/pnas.1015312108
Brunell, D., Weissbach, H., Hodder, P., Brot, N.
A high-throughput screening compatible assay for activators and inhibitors of methionine sulfoxide reductase a
Assay and Drug Development Technologies
2010
8:615-620
DOI: 10.1089/adt.2009.0263
Kota, S., Scampavia, L., Spicer, T., Beeler, A. B., Takahashi, V., Snyder, J. K., Porco, J. A., Hodder, P., Strosberg, A. D.
A time-resolved fluorescence-resonance energy transfer assay for identifying inhibitors of hepatitis c virus core dimerization
Assay and Drug Development Technologies
2010
8:96-105
DOI: 10.1089/adt.2009.0217
Madoux, F., Simanski, S., Chase, P., Mishra, J. K., Roush, W. R., Ayad, N. G., Hodder, P.
An ultra-high throughput cell-based screen for wee1 degradation inhibitors
Journal of Biomolecular Screening
2010
15:907-917
DOI: 10.1177/1087057110375848
Tanaka, K., Koresawa, M., Iida, M., Fukasawa, K., Stec, E., Cassaday, J., Chase, P., Rickert, K., Hodder, P., Takagi, T., Komatani, H.
Multiplexed random peptide library and phospho-specific antibodies facilitate human polo-like kinase 1 inhibitor screen
Assay and Drug Development Technologies
2010
8:47-62
DOI: 10.1089/adt.2009.0212
Weide, T., Saldanha, S. A., Minond, D., Spicer, T. P., Fotsing, J. R., Spaargaren, M., Frere, J. M., Bebrone, C., Sharpless, K. B., Hodder, P. S., Fokin, V. V.
Nh-1,2,3-triazole-based inhibitors of the vim-2 metallo-beta-lactamase: Synthesis and structure-activity studies
ACS Medicinal Chemistry Letters
2010
1:150-154
DOI: 10.1021/ml900022q
PMID: 20625539
Bachovchin, D. A., Wolfe, M. R., Masuda, K., Brown, S. J., Spicer, T. P., Fernandez-Vega, V., Chase, P., Hodder, P. S., Rosen, H., Cravatt, B. F.
Oxime esters as selective, covalent inhibitors of the serine hydrolase retinoblastoma-binding protein 9 (rbbp9)
Bioorganic & Medicinal Chemistry Letters
2010
20:2254-2258
DOI: 10.1016/j.bmcl.2010.02.011
PMID: 20207142
Brothers, S. P., Saldanha, S. A., Spicer, T. P., Cameron, M., Mercer, B. A., Chase, P., McDonald, P., Wahlestedt, C., Hodder, P. S.
Selective and brain penetrant neuropeptide y y2 receptor antagonists discovered by whole-cell high-throughput screening
Molecular Pharmacology
2010
77:46-57
DOI: 10.1124/mol.109.058677
Grimm, C., Jors, S., Saldanha, S. A., Obukhov, A. G., Pan, B. F., Oshima, K., Cuajungco, M. P., Chase, P., Hodder, P., Heller, S.
Small molecule activators of trpml3
Chemistry & Biology
2010
17:135-148
DOI: 10.1016/j.chembiol.2009.12.016
Lauer-Fields, J. L., Minond, D., Chase, P. S., Baillargeon, P. E., Saldanha, S. A., Stawikowska, R., Hodder, P., Fields, G. B.
High throughput screening of potentially selective mmp-13 exosite inhibitors utilizing a triple-helical fret substrate
Bioorganic & Medicinal Chemistry
2009
17:990-1005
DOI: 10.1016/j.bmc.2008.03.004
Doghman, M., Cazareth, J., Douguet, D., Madoux, F., Hodder, P., Lalli, E.
Inhibition of adrenocortical carcinoma cell proliferation by steroidogenic factor-1 inverse agonists
Journal of Clinical Endocrinology & Metabolism
2009
94:2178-2183
DOI: 10.1210/jc.2008-2163
Minond, D., Saldanha, S. A., Subramaniam, P., Spaargaren, M., Spicer, T., Fotsing, J. R., Weide, T., Fokin, V. V., Sharpless, K. B., Galleni, M., Bebrone, C., Lassaux, P., et al.
Inhibitors of vim-2 by screening pharmacologically active and click-chemistry compound libraries
Bioorganic & Medicinal Chemistry
2009
17:5027-5037
DOI: 10.1016/j.bmc.2009.05.070
Chung, C. C., Ohwaki, K., Schneeweis, J. E., Stec, E., Varnerin, J. P., Goudreau, P. N., Chang, A., Cassaday, J., Yang, L. H., Yamakawa, T., Kornienko, O., Hodder, P., et al.
A fluorescence-based thiol quantification assay for ultra-high-throughput screening for inhibitors of coenzyme a production
Assay and Drug Development Technologies
2008
6:361-374
DOI: 10.1089/adt.2007.105
Schroeter, T., Minond, D., Weiser, A., Dao, C., Habel, J., Spicer, T., Chase, P., Baillargeon, P., Scampavia, L., Schuerer, S., Chung, C., Mader, C., et al.
Comparison of miniaturized time-resolved fluorescence resonance energy transfer and enzyme-coupled luciferase high-throughput screening assays to discover inhibitors of rho-kinase ii (rock-ii)
Journal of Biomolecular Screening
2008
13:17-28
DOI: 10.1177/1087057107310806
Schurer, S. C., Brown, S. J., Gonzalez-Cabrera, P. J., Schaeffer, M. T., Chapman, J., Jo, E., Chase, P., Spicer, T., Hodder, P., Rosen, H.
Ligand-binding pocket shape differences between sphingosine 1-phosphate (s1p) receptors s1p(1) and s1p(3) determine efficiency of chemical probe identification by ultrahigh-throughput screening
ACS Chemical Biology
2008
3:486-498
DOI: 10.1021/cb800051m
PMID: 18590333
Madoux, F., Li, X. L., Chase, P., Zastrow, G., Cameron, M. D., Conkright, J. J., Griffin, P. R., Thacher, S., Hodder, P.
Potent, selective and cell penetrant inhibitors of sf-1 by functional ultra-high-throughput screening
Molecular Pharmacology
2008
73:1776-1784
DOI: 10.1124/mol.108.045963
Lauer-Fields, J. L., Spicer, T. P., Chase, P. S., Cudic, M., Burstein, G. D., Nagase, H., Hodder, P., Fields, G. B.
Screening of potential a, disintegrin and metalloproteinase with thrombospondin motifs-4 inhibitors using a collagen model fluorescence resonance energy transfer substrate
Analytical Biochemistry
2008
373:43-51
DOI: 10.1016/j.ab.2007.09.014
Roth, J., Madoux, F., Hodder, P., Roush, W. R.
Synthesis of small molecule inhibitors of the orphan nuclear receptor steroidogenic factor-1 (nr5a1) based on isoquinolinone scaffolds
Bioorganic & Medicinal Chemistry Letters
2008
18:2628-2632
DOI: 10.1016/j.bmcl.2008.03.027
Zuck, P., O'Donnell, G. T., Cassaday, J., Chase, P., Hodder, P., Strulovici, B., Ferrer, M.
Miniaturization of absorbance assays using the fluorescent properties of white microplates
Analytical Biochemistry
2005
342:254-259
DOI: 10.1016/j.ab.2005.04.029
Hale, J. J., Lynch, C. L., Neway, W., Mills, S. G., Hajdu, R., Keohane, C. A., Rosenbach, M. J., Milligan, J. A., Shei, G. J., Parent, S. A., Chrebet, G., Bergstrom, J., et al.
A rational utilization of high-throughput screening affords selective, orally bioavailable 1-benzyl-3-carboxyazetidine sphingosine-1-phosphate-1 receptor agonists
Journal of Medicinal Chemistry
2004
47:6662-6665
DOI: 10.1021/jm0492507
Hodder, P., Mull, R., Cassaday, J., Berry, K., Strulovici, B.
Miniaturization of intracellular calcium functional assays to 1536-well plate format using a fluorometric imaging plate reader
Journal of Biomolecular Screening
2004
9:417-426
DOI: 10.1177/1087057104264038
Kunapuli, P., Ransom, R., Murphy, K. L., Pettibone, D., Kerby, J., Grimwood, S., Zuck, P., Hodder, P., Lacson, R., Hoffman, I., Inglese, J., Strulovici, B.
Development of an intact cell reporter gene beta-lactamase assay for g protein-coupled receptors for high-throughput screening
Analytical Biochemistry
2003
314:16-29
DOI: 10.1016/s0003-2697(02)00587-0
Hodder, P., Cassaday, J., Peltier, R., Berry, K., Inglese, J., Feuston, B., Culberson, C., Bleicher, L., Cosford, N. D. P., Bayly, C., Suto, C., Varney, M., et al.
Identification of metabotropic glutamate receptor antagonists using an automated high-throughput screening system
Analytical Biochemistry
2003
313:246-254
DOI: 10.1016/s0003-2697(02)00608-5
Hodder, P. S., Beeson, C., Ruzicka, J.
Equilibrium and kinetic measurements of muscarinic receptor antagonism on living cells using bead injection spectroscopy
Analytical Chemistry
2000
72:3109-3115
DOI: 10.1021/ac991231v
Hodder, P. S., Ruzicka, J.
A flow injection renewable surface technique for cell-based drug discovery functional assays
Analytical Chemistry
1999
71:1160-1166
DOI: 10.1021/ac981102z
Scampavia, L. D., Hodder, P. S., Lahdesmaki, I., Ruzicka, J.
Automation of functional assays by flow injection fluorescence microscopy
Trends in Biotechnology
1999
17:443-447
DOI: 10.1016/s0167-7799(99)01375-x
Hodder, P. S., Blankenstein, G., Ruzicka, J.
Microfabricated flow chamber for fluorescence-based chemistries and stopped-flow injection cytometry
Analyst
1997
122:883-887
DOI: 10.1039/a701750b
Research
research overview
The Hodder laboratory, in collaboration with other scientists at Scripps and around the world, identifies “lead” compounds
that can help better understand and ultimately cure diseases such as cancer, diabetes, Alzheimer's and hepatitis. By combining robotics
, biology, chemistry and informatics, we are able to perform High-Throughput Screening
, a robotic process employing sophisticated automation, detection and assay technologies that tests hundreds of thousands of drug-like compounds for biological activity both rapidly and economically. In addition we have the personnel and facilities to engage both pre- and post-HTS activities, including HTS assay development
, cheminformatics
, compound synthesis/procurement, compound QC
(via LC-MS) and mechanism of action/profiling studies. We work with mammalian, yeast and bacterial targets. Our expertise can be accessed through collaborative mechanisms, such as the NIH’s Molecular Libraries initiative (http://mlpcn.florida.scripps.edu/
). In other efforts, we research and develop novel automation, instrumentation and assay technologies that benefit the HTS disciplines. We are also engaged in developing novel probes and therapeutics relevant to infectious disease research.
co-principal investigator on
Background
education and training