Publications in VIVO

Co-Author Network

Co-Investigator Network

Gruol, Donna Faculty Member

Positions

Associate Professor, Gruol Laboratory, Molecular and Cellular Neuroscience
Faculty Member, Kellogg School of Science and Technology, The Scripps Research Institute
Adjunct Professor, University of California, San Diego
Associate Professor, Molecular and Cellular Neuroscience, The Scripps Research Institute 2013 -
Associate Professor, Molecular and Integrative Neurosciences (MIND), The Scripps Research Institute - 2012

Dr. Donna Gruol examines the pathways and mechanisms involved in neuronal signaling in the mammalian central nervous system (CNS), developmental expression of signaling pathways, and the neuroadaptive mechanisms through which CNS disease and drugs alter neuronal signaling and viability.

Affiliation

head of

Gruol Laboratory Associate Professor

Publications

selected publications

academic article
- Gruol, D. L. Neuroimmune regulation of neurophysiology in the cerebellum Cerebellum 2013 DOI:10.1007/s12311-012-0445-8 PMID:23315008
- Nelson, T. E., Engberink, A. O., Hernandez, R., Puro, A., Huitron-Resendiz, S., Hao, C., De Graan, P. N. E., Gruol, D. L. Altered synaptic transmission in the hippocampus of transgenic mice with enhanced central nervous systems expression of interleukin-6 Brain Behavior and Immunity 2012 26:959-971 DOI:10.1016/j.bbi.2012.05.005
- Gruol, D., Manto, M., Haines, D. Ca2+ signaling in cerebellar purkinje neurons-editorial Cerebellum 2012 11:605-608 DOI:10.1007/s12311-012-0404-4
- Gruol, D. L., Nelson, T. E., Hao, C., Michael, S., Vukojevic, V., Ming, Y., Terenius, L. Ethanol alters opioid regulation of ca2+influx through l-type ca2+channels in pc12 cells Alcoholism-Clinical and Experimental Research 2012 36:443-456 DOI:10.1111/j.1530-0277.2011.01631.x PMID:22014285
- Nelson, T. E., Hao, C., Manos, J., Ransohoff, R. M., Gruol, D. L. Altered hippocampal synaptic transmission in transgenic mice with astrocyte-targeted enhanced ccl2 expression Brain Behavior and Immunity 2011 25:S106-S119 DOI:10.1016/j.bbi.2011.02.013
- Gruol, D. L., Puro, A., Hao, C., Blakely, P., Janneke, E., Vo, K. Neuroadaptive changes in cerebellar neurons induced by chronic exposure to il-6 Journal of Neuroimmunology 2011 239:28-36 DOI:10.1016/j.jneuroim.2011.08.009
- Kuijpers, M., van Gassen, K. L. I., de Graan, P. N. E., Gruol, D. Chronic exposure to the chemokine ccl3 enhances neuronal network activity in rat hippocampal cultures Journal of Neuroimmunology 2010 229:73-80 DOI:10.1016/j.jneuroim.2010.07.004
- Gruol, D. L., Netzeband, J. G., Nelson, T. E. Somatic ca(2+) signaling in cerebellar purkinje neurons Journal of Neuroscience Research 2010 88:275-289 DOI:10.1002/jnr.22204
- Cho, J., Nelson, T. E., Bajova, H., Gruol, D. L. Chronic cxcl10 alters neuronal properties in rat hippocampal culture Journal of Neuroimmunology 2009 207:92-100 DOI:10.1016/j.jneuroim.2008.12.007
- Bajova, H., Nelson, T. E., Gruol, D. L. Chronic cxcl10 alters the level of activated erk1/2 and transcriptional factors creb and nf-kappa b in hippocampal neuronal cell culture Journal of Neuroimmunology 2008 195:36-46 DOI:10.1016/j.jneuroim.2008.01.003
- Sabeti, J., Gruol, D. L. Emergence of nmdar-independent long-term potentiation at hippocampal ca1 synapses following early adolescent exposure to chronic intermittent ethanol: Role for sigma-receptors Hippocampus 2008 18:148-168 DOI:10.1002/hipo.20379
- Netzeband, J. G., Gruol, D. L. Mglur1 agonists elicit a ca2+ signal and membrane hyperpolarization mediated by apamin-sensitive potassium channels in immature rat purkinje neurons Journal of Neuroscience Research 2008 86:293-305 DOI:10.1002/jnr.21493
- Cho, J., Gruol, D. L. The chemokine ccl2 activates p38 mitogen-activated protein kinase pathway in cultured rat hippocampal cells Journal of Neuroimmunology 2008 199:94-103 DOI:10.1016/j.jneuroim.2008.05.011
- Vereyken, E. J. F., Bajova, H., Chow, S., de Graan, P. N. E., Gruol, D. L. Chronic interleukin-6 alters the level of synaptic proteins in hippocampus in culture and in vivo European Journal of Neuroscience 2007 25:3605-3616 DOI:10.1111/j.1460-9568.2007.05615.x
- Sabeti, J., Nelson, T. E., Purdy, R. H., Gruol, D. L. Steroid pregnenolone sulfate enhances nmda-receptor-independent long-term potentiation at hippocampal ca1 synapses: Role for l-type calcium channels and sigma-receptors Hippocampus 2007 17:349-369 DOI:10.1002/hipo.20273
- Gruol, D. L., Quina, L. A., Netzeband, J. G., Nguyen, D., Gullette, C. E. Developmental changes in ca2+-regulated functions of early postnatal purkinje neurons Journal of Neuroscience Research 2006 83:1381-1392 DOI:10.1002/jnr.20844
- Gruol, D. L., Netzeband, J. G., Schneeloch, J., Gullette, C. E. L-type ca2+ channels contribute to current-evoked spike firing and associated ca2+ signals in cerebellar purkinje neurons Cerebellum 2006 5:146-154 DOI:10.1080/14734220600719692
- Nelson, T. E., Ur, C. L., Gruol, D. L. Chronic intermittent ethanol exposure enhances nmda-receptor-mediated synaptic responses and nmda receptor expression in hippocampal ca1 region Brain Research 2005 1048:69-79 DOI:10.1016/j.brainres.2005.04.041
- Gruol, D. L., Netzeband, J. G., Quina, L. A., Blakely-Gonzalez, P. K. Contribution of l-type channels to ca2+ regulation of neuronal properties in early developing purkinje neurons Cerebellum 2005 4:128-139 DOI:10.1080/14734220510007969
- Gruol, D. L., Nelson, T. E. Purkinje neuron physiology is altered by the inflammatory factor interleukin-6 Cerebellum 2005 4:198-205 DOI:10.1080/14734220500199987
- van Gassen, K. L. I., Netzeband, J. G., de Graan, P. N. E., Gruol, D. L. The chemokine ccl2 modulates ca2+ dynamics and electrophysiological properties of cultured cerebellar purkinje neurons European Journal of Neuroscience 2005 21:2949-2957 DOI:10.1111/j.1460-9568.2005.04113.x
- Rempel, J. D., Quina, L. A., Blakely-Gonzales, P. K., Buchmeier, M. J., Gruol, D. L. Viral induction of central nervous system innate immune responses Journal of Virology 2005 79:4369-4381 DOI:10.1128/jvi.79.7.4369-4381.2005
- Nelson, T. E., Netzeband, J. G., Gruol, D. L. Chronic interleukin-6 exposure alters metabotropic glutamate receptor-activated calcium signalling in cerebellar purkinje neurons European Journal of Neuroscience 2004 20:2387-2400 DOI:10.1111/j.1460-9568.2004.03706.x
- Conroy, S. M., Nguyen, V., Quina, L. A., Blakely-Gonzales, P., Ur, C., Netzeband, J. G., Prieto, A. L., Gruol, D. L. Interleukin-6 produces neuronal loss in developing cerebellar granule neuron cultures Journal of Neuroimmunology 2004 155:43-54 DOI:10.1016/j.jneuroim.2004.06.014
- Nelson, T. E., Gruol, D. L. The chemokine cxcl10 modulates excitatory activity and intracellular calcium signaling in cultured hippocampal neurons Journal of Neuroimmunology 2004 156:74-87 DOI:10.1016/j.jneuroim.2004.07.009
- van Dalen, J. J. W., Gerendasy, D. D., de Graan, P. N. E., Schrama, L. H., Gruol, D. L. Calcium dynamics are altered in cortical neurons lacking the calmodulin-binding protein rc3 European Journal of Neuroscience 2003 18:13-22 DOI:10.1046/j.1460-9568.2003.02720.x
- Qiu, Z. H., Gruol, D. L. Interleukin-6, beta-amyloid peptide and nmda interactions in rat cortical neurons Journal of Neuroimmunology 2003 139:51-57 DOI:10.1016/s0165-5728(03)00158-9
- Roberto, M., Nelson, T. E., Ur, C. L., Brunelli, M., Sanna, P. P., Gruol, D. L. The transient depression of hippocampal ca1 ltp induced by chronic intermittent ethanol exposure is associated with an inhibition of the map kinase pathway European Journal of Neuroscience 2003 17:1646-1654 DOI:10.1046/j.1460-9568.2003.02614.x
- Netzeband, J. G., Schneeloch, J. R., Trotter, C., Caguioa-Aquino, J. N., Gruol, D. L. Chronic ethanol treatment and withdrawal alter acpd-evoked calcium signals in developing purkinje neurons Alcoholism-Clinical and Experimental Research 2002 26:386-393 DOI:10.1111/j.1530-0277.2002.tb02550.x
- Nelson, T. E., Ur, C. L., Gruol, D. L. Chronic interleukin-6 exposure alters electrophysiological properties and calcium signaling in developing cerebellar purkinje neurons in culture Journal of Neurophysiology 2002 88:475-486 DOI:10.1152/jn.00306.2001
- Roberto, M., Nelson, T. E., Ur, C. L., Gruol, D. L. Long-term potentiation in the rat hippocampus is reversibly depressed by chronic intermittent ethanol exposure Journal of Neurophysiology 2002 87:2385-2397 DOI:10.1152/jn.00145.2001
- O'Barr, S. A., Caguioa, J., Gruol, D., Perkins, G., Ember, J. A., Hugli, T., Cooper, N. R. Neuronal expression of a functional receptor for the c5a complement activation fragment Journal of Immunology 2001 166:4154-4162
- Liljelund, P., Netzeband, J. G., Gruol, D. L. L-type calcium channels mediate calcium oscillations in early postnatal purkinje neurons Journal of Neuroscience 2000 20:7394-7403
- Nelson, T. E., Campbell, I. L., Gruol, D. L. Altered physiology of purkinje neurons in cerebellar slices from transgenic mice with chronic central nervous system expression of interleukin-6 Neuroscience 1999 89:127-136 DOI:10.1016/s0306-4522(98)00316-9
- Jacquin, T. D., Gruol, D. L. Ca2+ regulation of a large conductance k+ channel in cultured rat cerebellar purkinje neurons European Journal of Neuroscience 1999 11:735-739 DOI:10.1046/j.1460-9568.1999.00478.x
- Netzeband, J. G., Conroy, S. M., Parsons, K. L., Gruol, D. L. Cannabinoids enhance nmda-elicited ca2+ signals in cerebellar granule neurons in culture Journal of Neuroscience 1999 19:8765-8777
- Netzeband, J. G., Trotter, C., Caguioa, J. N., Gruol, D. L. Chronic ethanol exposure enhances ampa-elicited ca2+ signals in the somatic and dendritic regions of cerebellar purkinje neurons Neurochemistry International 1999 35:163-174 DOI:10.1016/s0197-0186(99)00058-3
- Netzeband, J. G., Trotter, C., Parsons, K. L., Gruol, D. L. Chronic ethanol treatment alters ampa-induced calcium signals in developing purkinje neurons Brain Research 1999 826:270-280 DOI:10.1016/s0006-8993(99)01309-8
- Nelson, T. E., Ur, C. L., Gruol, D. L. Chronic intermittent ethanol exposure alters ca1 synaptic transmission in rat hippocampal slices Neuroscience 1999 94:431-442 DOI:10.1016/s0306-4522(99)00336-x
- Meyer, J. H., Lee, S., Wittenberg, G. F., Randall, R. D., Gruol, D. L. Neurosteroid regulation of inhibitory synaptic transmission in the rat hippocampus in vitro Neuroscience 1999 90:1177-1183 DOI:10.1016/s0306-4522(98)00543-0
- Przewlocki, R., Parsons, K. L., Sweeney, D. D., Trotter, C., Netzeband, J. G., Siggins, G. R., Gruol, D. L. Opioid enhancement of calcium oscillations and burst events involving nmda receptors and l-type calcium channels in cultured hippocampal neurons Journal of Neuroscience 1999 19:9705-9715
- Qiu, Z. H., Sweeney, D. D., Netzeband, J. G., Gruol, D. L. Chronic interleukin-6 alters nmda receptor-mediated membrane responses and enhances neurotoxicity in developing cns neurons Journal of Neuroscience 1998 18:10445-10456
- Gruol, D. L., Ryabinin, A. E., Parsons, K. L., Cole, M., Wilson, M. C., Qiu, Z. Neonatal alcohol exposure reduces nmda induced ca2+ signaling in developing cerebellar granule neurons Brain Research 1998 793:12-20 DOI:10.1016/s0006-8993(98)00014-6
- Gruol, D., Yu, N., Parsons, K. L., Billaud, J. N., Elder, J. H., Phillips, T. R. Neurotoxic effects of feline immunodeficiency virus, fiv-ppr Journal of Neurovirology 1998 4:415-425
- Gruol, D. L., Parsons, K. L., DiJulio, N. Acute ethanol alters calcium signals elicited by glutamate receptor agonists and k+ depolarization in cultured cerebellar purkinje neurons Brain Research 1997 773:82-89 DOI:10.1016/s0006-8993(97)00912-8
- Sorg, O., Horn, T. F. W., Yu, N. C., Gruol, D. L., Bloom, F. E. Inhibition of astrocyte glutamate uptake by reactive oxygen species: Role of antioxidant enzymes Molecular Medicine 1997 3:431-440
- Netzeband, J. G., Parsons, K. L., Sweeney, D. D., Gruol, D. L. Metabotropic glutamate receptor agonists alter neuronal excitability and ca2+ levels via the phospholipase c transduction pathway in cultured purkinje neurons Journal of Neurophysiology 1997 78:63-75
- Gruol, D. L., Nelson, T. E. Physiological and pathological roles of interleukin-6 in the central nervous system Molecular Neurobiology 1997 15:307-339 DOI:10.1007/bf02740665
- Gruol, D. L., Netzeband, J. G., Parsons, K. L. Ca2+ signaling pathways linked to glutamate receptor activation in the somatic and dendritic regions of cultured cerebellar purkinje neurons Journal of Neurophysiology 1996 76:3325-3340
- Gruol, D. L., Parsons, K. L. Chronic alcohol reduces calcium signaling elicited by glutamate receptor stimulation in developing cerebellar neurons Brain Research 1996 728:166-174 DOI:10.1016/s0006-8993(96)00185-0
- Gottlieb, R. A., Gruol, D. L., Zhu, J. Y., Engler, R. L. Preconditioning in rabbit cardiomyocytes - role of ph, vacuolar proton atpase, and apoptosis Journal of Clinical Investigation 1996 97:2391-2398 DOI:10.1172/jci118683
- Randall, R. D., Lee, S. Y., Meyer, J. H., Wittenberg, G. F., Gruol, D. L. Acute alcohol blocks neurosteroid modulation of synaptic transmission and long-term potentiation in the rat hippocampal slice Brain Research 1995 701:238-248 DOI:10.1016/0006-8993(95)01007-9
- Gruol, D. L., Curry, J. G. Calcium signals elicited by quisqualate in cultured purkinje neurons show developmental-changes in sensitivity to acute alcohol Brain Research 1995 673:1-12 DOI:10.1016/0006-8993(94)01324-b
- Holliday, J., Parsons, K., Curry, J., Lee, S. Y., Gruol, D. L. Cerebellar granule neurons develop elevated calcium responses when treated with interleukin-6 in culture Brain Research 1995 673:141-148 DOI:10.1016/0006-8993(94)01417-g
- Qiu, Z. H., Parsons, K. L., Gruol, D. L. Interleukin-6 selectively enhances the intracellular calcium response to nmda in developing cns neurons Journal of Neuroscience 1995 15:6688-6699
- Netzeband, J. G., Gruol, D. L. Modulatory effects of acute ethanol on metabotropic glutamate responses in cultured purkinje neurons Brain Research 1995 688:105-113 DOI:10.1016/0006-8993(95)00517-t
- Gruol, D. L., Parsons, K. L. Chronic exposure to alcohol during development alters the calcium currents of cultured cerebellar purkinje neurons Brain Research 1994 634:283-290 DOI:10.1016/0006-8993(94)91931-3
- Meyer, J. H., Gruol, D. L. Dehydroepiandrosterone-sulfate alters synaptic potentials in area ca1 of the hippocampal slice Brain Research 1994 633:253-261
- Fox, E. A., Gruol, D. L. Corticotropin-releasing factor suppresses the afterhyperpolarization in cerebellar purkinje neurons Neuroscience Letters 1993 149:103-107 DOI:10.1016/0304-3940(93)90358-r
- Holliday, J., Gruol, D. L. Cytokine stimulation increases intracellular calcium and alters the response to quisqualate in cultured cortical astrocytes Brain Research 1993 621:233-241 DOI:10.1016/0006-8993(93)90111-y
- Fox, E. A., Gruol, D. L. Ionotropic and metabotropic components of electrophysiological response of cerebellar purkinje neurons to excitatory amino-acids Brain Research 1993 631:59-64 DOI:10.1016/0006-8993(93)91186-v
- Urrutia, A., Gruol, D. L. Acute alcohol alters the excitability of cerebellar purkinje neurons and hippocampal-neurons in culture Brain Research 1992 569:26-37 DOI:10.1016/0006-8993(92)90365-g
- Gruol, D. L. Chronic exposure to alcohol during development alters the responses to excitatory amino-acids in cultured purkinje neurons Brain Research 1992 574:271-279
- Gruol, D. L., Deal, C. R., Yool, A. J. Developmental-changes in calcium conductances contribute to the physiological maturation of cerebellar purkinje neurons in culture Journal of Neuroscience 1992 12:2838-2848
- Yool, A. J., Krieger, R. M., Gruol, D. L. Multiple ionic mechanisms are activated by the potent agonist quisqualate in cultured cerebellar purkinje neurons Brain Research 1992 573:83-94 DOI:10.1016/0006-8993(92)90116-q
- Gruol, D. L. Chronic exposure to alcohol during development alters the membrane-properties of cerebellar purkinje neurons in culture Brain Research 1991 558:1-12 DOI:10.1016/0006-8993(91)90707-3
- Franklin, C. L., Gruol, D. L. Developmental expression of excitatory amino-acid responses in cerebellar purkinje neurons in culture Brain Research 1991 543:219-226 DOI:10.1016/0006-8993(91)90031-p
- Gruol, D. L., Jacquin, T., Yool, A. J. Single-channel k+ currents recorded from the somatic and dendritic regions of cerebellar purkinje neurons in culture Journal of Neuroscience 1991 11:1002-1015
- Raska, I., Ochs, R. L., Andrade, L. E. C., Chan, E. K. L., Burlingame, R., Peebles, C., Gruol, D., Tan, E. M. Association between the nucleolus and the coiled body Journal of Structural Biology 1990 104:120-127
- Gruol, D. L., Dionne, V. E., Yool, A. J. Multiple voltage-sensitive k+ channels regulate dendritic excitability in cerebellar purkinje neurons Neuroscience Letters 1989 97:97-102 DOI:10.1016/0304-3940(89)90146-8
- Joels, M., Yool, A. J., Gruol, D. L. Unique properties of non-n-methyl-d-aspartate excitatory responses in cultured purkinje neurons Proceedings of the National Academy of Sciences of the United States of America 1989 86:3404-3408 DOI:10.1073/pnas.86.9.3404
- Yool, A. J., Dionne, V. E., Gruol, D. L. Developmental-changes in k+-selective channel activity during differentiation of the purkinje neuron in culture Journal of Neuroscience 1988 8:1971-1980
- Gruol, D. L., Crimi, C. P. Morphological and physiological-properties of rat cerebellar neurons in mature and developing cultures Developmental Brain Research 1988 41:135-146 DOI:10.1016/0165-3806(88)90177-0
- Franklin, C. L., Gruol, D. L. Acute ethanol alters the firing pattern and glutamate response of cerebellar purkinje neurons in culture Brain Research 1987 416:205-218 DOI:10.1016/0006-8993(87)90899-7
- Yool, A. J., Gruol, D. L. Development of spontaneous and glutamate-evoked activity is altered by chronic ethanol in cultured cerebellar purkinje neurons Brain Research 1987 420:205-219 DOI:10.1016/0006-8993(87)91240-6
- Gruol, D. L., Franklin, C. L. Morphological and physiological differentiation of purkinje neurons in cultures of rat cerebellum Journal of Neuroscience 1987 7:1271-1293
- Siggins, G. R., Gruol, D., Aldenhoff, J., Pittman, Q. Electrophysiological actions of corticotropin-releasing factor in the central nervous-system Federation Proceedings 1985 44:237-242
- Gruol, D. L. Single channel analysis of voltage-sensitive k+ channels in cultured purkinje neurons Biophysical Journal 1984 45:53-55
- Aldenhoff, J. B., Gruol, D. L., Rivier, J., Vale, W., Siggins, G. R. Corticotropin releasing-factor decreases postburst hyperpolarizations and excites hippocampal-neurons Science 1983 221:875-877 DOI:10.1126/science.6603658
- Gruol, D. L. Cultured cerebellar neurons - endogenous and exogenous components of purkinje-cell activity and membrane response to putative transmitters Brain Research 1983 263:223-241 DOI:10.1016/0006-8993(83)90315-3
- Gruol, D. L., Chavkin, C., Valentino, R. J., Siggins, G. R. Dynorphin-a alters the excitability of pyramidal neurons of the rat hippocampus invitro Life Sciences 1983 33:533-536 DOI:10.1016/0024-3205(83)90558-1
- Gruol, D. L. Ethanol alters synaptic activity in cultured spinal-cord neurons Brain Research 1982 243:25-33 DOI:10.1016/0006-8993(82)91117-9
- Siggins, G. R., McGinty, J. F., Morrison, J. H., Pittman, Q. J., Zieglgansberger, W., Magistretti, P. J., Gruol, D. L. The role of neuropeptides in the hippocampal-formation Advances in Biochemical Psychopharmacology 1982 33:413-422
- Gruol, D. L., Siggins, G. R., Padjen, A. L., Forman, D. S. Explant cultures of adult amphibian sympathetic-ganglia - electro-physiological and pharmacological investigation of neurotransmitter and nucleotide action Brain Research 1981 223:81-106 DOI:10.1016/0006-8993(81)90808-8
- Gruol, D. L., Smith, T. G. Opiate antagonism of glycine-evoked membrane polarizations in cultured mouse spinal-cord neurons Brain Research 1981 223:355-365 DOI:10.1016/0006-8993(81)91148-3
- Gruol, D. L., Barker, J. L., Huang, L. Y. M., Macdonald, J. F., Smith, T. G. Hydrogen-ions have multiple effects on the excitability of cultured mammalian neurons Brain Research 1980 183:247-252 DOI:10.1016/0006-8993(80)90138-9
- Gruol, D. L., Barker, J. L., Smith, T. G. Naloxone antagonism of gaba-evoked membrane polarizations in cultured mouse spinal-cord neurons Brain Research 1980 198:323-332
- Barker, J. L., Gruol, D. L., Huang, L. Y. M., Macdonald, J. F., Smith, T. G. Peptides - pharmacological evidence for 3 forms of chemical excitability in cultured mouse spinal neurons Neuropeptides 1980 1:63-82 DOI:10.1016/0143-4179(80)90010-4
- Gruol, D. L., Weinreich, D. 2 pharmacologically distinct histamine receptors mediating membrane hyperpolarization on identified neurons of aplysia-californica Brain Research 1979 162:281-301 DOI:10.1016/0006-8993(79)90290-7
- Gruol, D. L., Weinreich, D. Cooperative interactions of histamine and competitive antagonism by cimetidine at neuronal histamine-receptors in the marine mollusk, aplysia-californica Neuropharmacology 1979 18:415-421 DOI:10.1016/0028-3908(79)90151-5
- Siggins, G. R., Gruol, D. L., Padjen, A. L., Forman, D. S. Purine and pyrimidine mononucleotides depolarize neurons of explanted amphibian sympathetic-ganglia Nature 1977 270:263-265 DOI:10.1038/270263a0
- Gruol, D., Rawson, J. R. Y., Haselkorn, R. Ribosomal-rna genes in nucleus and chloroplast of euglena Biochimica Et Biophysica Acta 1975 414:20-29 DOI:10.1016/0005-2787(75)90122-7

Research

research overview

Cellular and Molecular Mechanisms of Neuronal Signaling in the CNS

The research interests of this laboratory center on the pathways and mechanisms involved in neuronal signaling in the mammalian central nervous system (CNS), developmental expression of signaling pathways, and the neuroadaptive mechanisms through which CNS disease and drugs alter neuronal signaling and viability. To address these issues we use electrophysiological techniques (whole cell current clamp, voltage clamp and single channel recordings), fura-2 based microscopic imaging of intracellular calcium, biochemical and gene array analyses, immunohistochemical techniques and in vitro model systems (primary cultures of CNS neurons and acutely isolated brain slices). Current research projects include: (a) identification of neuroadaptive mechanisms involved in CNS actions of cytokines and chemokines important in CNS disease, (b) pathways involved in intracellular calcium signaling in CNS neurons, (c) the physiological role of cannabinoid receptors in CNS neuronal function, and (d) the mechanisms involved in neuroadaption to chronic alcohol exposure at synaptic pathways in the hippocampus.

principal investigator on

Alcohol-chemokine interactions and neurotransmission awarded by National Institute on Alcohol Abuse and Alcoholism 2009 - 2011
Alcohol/naltrexone; neuropeptide interaction with opioid receptor dynamics studie awarded by National Institute on Alcohol Abuse and Alcoholism 2008 - 2010
An integrative sturcture/functional analysis of mu-opioid receptor variants awarded by National Institute on Drug Abuse 2010 - 2012
Il-6 regulation of hippocampal synaptic function awarded by National Institute of Mental Health 2009 - 2011

Background

education and training

Ph.D., Illinois Institute of Technology 1975