recent publications
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academic article
- Marciano, D. P., Kuruvilla, D. S., Boregowda, S. V., Asteian, A., Hughes, T. S., Garcia-Ordonez, R., Corzo, C. A., Khan, T. M., Novick, S. J., Park, H., Kojetin, D. J., Phinney, D. G., et al. Pharmacological repression of PPARĪ³ promotes osteogenesis Nature Communications 2015 6:7443 DOI:10.1038/ncomms8443 PMID:26068133 PMCID:PMC4471882
- Kojetin, D. J., Matta-Camacho, E., Hughes, T. S., Srinivasan, S., Nwachukwu, J. C., Cavett, V., Nowak, J., Chalmers, M. J., Marciano, D. P., Kamenecka, T. M., Shulman, A. I., Rance, M., et al. Structural mechanism for signal transduction in RXR nuclear receptor heterodimers Nature Communications 2015 6:8013 DOI:10.1038/ncomms9013 PMID:26289479 PMCID:PMC4547401
- Choi, J. H., Banks, A. S., Kamenecka, T. M., Busby, S. A., Chalmers, M. J., Kumar, N., Kuruvilla, D. S., Shin, Y. S., He, Y. J., Bruning, J. B., Marciano, D. P., Cameron, M. D., et al. Antidiabetic actions of a non-agonist PPARĪ³ ligand blocking Cdk5-mediated phosphorylation Nature 2011 477:477-481 DOI:10.1038/nature10383 PMID:21892191 PMCID:PMC3179551
- Zhang, J., Chalmers, M. J., Stayrook, K. R., Burris, L. L., Wang, Y. J., Busby, S. A., Pascal, B. D., Garcia-Ordonez, R. D., Bruning, J. B., Istrate, M. A., Kojetin, D. J., Dodge, J. A., et al. DNA binding alters coactivator interaction surfaces of the intact VDR-RXR complex Nature Structural & Molecular Biology 2011 18:556-563 DOI:10.1038/nsmb.2046 PMID:21478866 PMCID:PMC3087838
- Bruning, J. B., Parent, A. A., Gil, G., Zhao, M., Nowak, J., Pace, M. C., Smith, C. L., Afonine, P. V., Adams, P. D., Katzenellenbogen, J. A., Nettles, K. W. Coupling of receptor conformation and ligand orientation determine graded activity Nature Chemical Biology 2010 6:837-843 DOI:10.1038/nchembio.451 PMID:20924370 PMCID:PMC2974172
- Nettles, K. W., Bruning, J. B., Gil, G., Nowak, J., Sharma, S. K., Hahm, J. B., Kulp, K., Hochberg, R. B., Zhou, H., Katzenellenbogen, J. A., Katzenellenbogen, B. S., Kim, Y., et al. NF kappa B selectivity of estrogen receptor ligands revealed by comparative crystallographic analyses Nature Chemical Biology 2008 4:241-247 DOI:10.1038/nchembio.76 PMID:18344977 PMCID:PMC2659626
- Zhou, H. B., Nettles, K. W., Bruning, J. B., Kim, Y., Joachimiak, A., Sharma, S., Carlson, K. E., Stossi, F., Katzenellenbogen, B. S., Greene, G. L., Katzenellenbogen, J. A. Elemental isomerism: A boron-nitrogen surrogate for a carbon-carbon double bond increases the chemical diversity of estrogen receptor ligands Chemistry & Biology 2007 14:659-669 DOI:10.1016/j.chembiol.2007.04.009 PMID:17584613
- Bruning, J. B., Chalmers, M. J., Prasad, S., Busby, S. A., Kamenecka, T. M., He, Y. J., Nettles, K. W., Griffin, P. R. Partial agonists activate PPAR gamma using a helix 12 independent mechanism Structure 2007 15:1258-1271 DOI:10.1016/j.str.2007.07.014 PMID:17937915
- Nettles, K. W., Bruning, J. B., Gil, G., O'Neill, E. E., Nowak, J., Guo, Y., Kim, Y., DeSombre, E. R., Dilis, R., Hanson, R. N., Joachimiak, A., Greene, G. L. Structural plasticity in the oestrogen receptor ligand-binding domain EMBO Reports 2007 8:563-568 DOI:10.1038/sj.embor.7400963 PMID:17468738 PMCID:PMC2002528